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Doctor insights on: Primary Sclerosing Kolangitis

Yes: The goal of managing acute attacks is antibiotics and IV fluids. In about 15%, emergency decompression or surgery is needed. Prevention of future attacks of cholangitis is based on removing biliary stones and debris, dilation or resection of strictures, and establishing optimal biliary drainage. Also important to rule out the clonorchis parasite. Your GI doctor can discuss newest treatments. ...Read more

No: It can cause generalised itching no pain. ...Read more

Yes: Yes there is an association. See this link: http://www.Mayoclinic.Com/health/primary-sclerosing-cholangitis/ds00918/dsection=risk-factors. ...Read more

Depends: On stage. Usually it has poor response to chronic meds, and antibiotics are used for superimposed infections in times of flare ups. ...Read more

See below: Complicated for a short answer here. See this site........http://www.mayoclinic.org/primary-sclerosing-cholangitis/. ...Read more

Similar symptoms: Distinct diseases that announce themselves in the same way. Both destroy the small bile ducts within the liver and produce jaundice, itching and sometimes failure of the liver. The microscopic picture, labs, and treatment options are as strikingly different as the presentations are similar. ...Read more

Yes: It is a disease that slowly progresses and eventually without treatment leads to hepatic failure which has a very high mortality rate. ...Read more

Difficult problem: Psc: autoimmune swelling/scarring of bile ducts within and outside the liver; often associated with infl. Bowel (usually ulc colitis). Increased risk for biliary ca. Med rx for itch, biochem abnormalities, e.g. Urso (bear bile), antihistamines, antibiotics for infections, vitamin supllements for deficiencies. Ercp procedure may open some strictures (narrowing). Ultimately, may need liver transpla. ...Read more

It can.: Primary sclerosing cholangitis (= psc, inflammation of bile ducts) can give symptoms such as itching, pain in the right upper abdomen, fevers, chills, night sweats, and jaundice (yellow skin, yellow whites of the eyes). Most people with this illness have ulcerative colitis, which has symptoms of its own (eg. Bloody diarrhea, abdominal pain). Many with psc eventually need liver transplant. ...Read more

Bile duct obstructio: Idiopathic (probably autoimmune) progressive scarring and narrowing of the bile ducts. May need surgical intervention or transplant This reference may help: http://www.mayoclinic.org/diseases-conditions/primary-sclerosing-cholangitis/basics/definition/CON-20029446 ...Read more

Basically no: There's a pair of genes that carry the ability to develop the disease and these run in families, but it's not inherited like sickle cell, huntington's or some of the other familiar entities. http://www.medicalnewstoday.com/releases/151640.php. ...Read more

Very low: PSC is most commonly seen in patients with ulcerative colitis. Patients with PSC have 60-72% association with ulcerative colitis; low genetic and immunologic factors are attributed to PSC. ...Read more

Immune dysregulation: The immune system is not functioning normally in primary biliary cirrhosis. That and the chronic inflammation contrive to raise IgM. ...Read more

No: Liver hemangiomas occur at random and are harmless. ...Read more

Yes: Unfortunately there is a relationship , 5 % of ulcerative colitis ( uc ) will have sclerosing cholangitis (sc ) 25% to 90% of sc patients will have uc, to less extent with crohn's disease. ...Read more

PSC: Primary sclerosing cholangitis (psc) is a chronic liver disease caused by progressive inflammation and scarring of the bile ducts of the liver. The inflammation impedes the flow of bile to the gut, which can ultimately lead to liver cirrhosis, liver failure and liver cancer. The underlying cause of the inflammation is believed to be autoimmunity. ...Read more

Not fusiform: It causes strictures and shrinking of the bilary tree. ...Read more

Gastroenterologist: Your regular doctor can make the initial diagnosis but you probably want to be followed by a gastroenterologist. ...Read more

PSC is progressive: You do not state whether your sclerosing cholangitis (sc) is primary or secondary, primary sc is an autoimmune disorder where the bile ducts become inflamed, leading to blockage of bile flow leading to liver damage. Secondary sc is due to other type of bile duct injury, but blockage leads to liver damage. Psc is progressive, ssc can only be treated if the blockage is relieved. See a hematologist. ...Read more

Usually a gallstone: Usually a gallstone causing obstruction of the common bile duct can cause sudden painful jaundice, sometimes with associated cholangitis (infection of the bile) This requires drainage and extraction of the stone from the common bile duct with a procedure call ERCP. Other causes can be tumors causing obstruction, which is more often painless and gradual. ...Read more