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Doctor insights on: Primary Ovarian Insufficiency Williams Syndrome

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What is the definition or description of: Primary ovarian insufficiency?

What is the definition or description of: Primary ovarian insufficiency?

Early failure: Premature ovarian failure is a loss of normal function of your ovaries before age 40. If your ovaries fail, they don't produce normal amounts of the hormone estrogen or release eggs regularly.

Dr. Michael Opsahl
28 doctors shared insights

Ovarian Insufficiency (Definition)

"Primary ovarian insufficiency describes a spectrum of declining ovarian functions and reduced fecundity due premature decrease in follicle number, an increase in follicle destruction or poor response to gonadotropins".This abnormal "Hypoestrogenic state" increases risks of vasomotor symptoms, urogenital atrophy, osteoporosis, fractures, cardiovascular diseases and other ...Read more


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What is the treatment for primary ovarian insufficiency?

What is the treatment for primary ovarian insufficiency?

Trying to conceive?: If not trying to conceive: bone density scan, calcium, vitamin d, and hormone replacement with estrogen and progestin. We look for and treat any adrenal insufficiency. If you're trying to conceive, 5-10% of women with poi will get pregnant on their own after diagnosis, but if you truly have poi we don't have good fertility treatments using your own eggs. Egg donation or embryo donation are best.

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What are the tests for primary ovarian insufficiency?

What are the tests for primary ovarian insufficiency?

Many tests, see REI: Reproductive endocrinology md will confirm poi - pregnancy test, fsh, lh, estradiol, amh, thyroid and prolactin tests, pelvic ultrasound. Test for genetic causes: karyotype looking for turner's syndrome, fragile x premutation testing, fish test for sry (y-chromosome material). Test adrenal antibodies which cause addison's disease. Screen for diabetes, thyroid antibodies, and parathyroid disease.

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What are the symptoms associated with primary ovarian insufficiency?

What are the symptoms associated with primary ovarian insufficiency?

Irregular/ no period: Irregular cycles or no periods, especially in a woman who was regular before, is a common sign. However there are many other causes of irregular cycles that we need to exclude. Hot flashes, vaginal dryness, or mood changes may occur, particularly if the woman's periods are stopped. Some women with primary ovarian insufficiency still have regular periods but see md for difficulty getting pregnant.

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Is it common for primary ovarian insufficiency to develop postpartum?

Is it common for primary ovarian insufficiency to develop postpartum?

Early menopause: Premature ovarian failure can occur at any age, but it is unusual immediately following pregnancy. Regular menses suggest ovulation and a healthy ovary, but there are many causes of lack of menses after having a baby. Included considerations are breastfeeding, polycystic ovaries (estrogen is produced, but no ovulation), another pregnancy! pituitary failure (sheehan's syndrome) is a rare cause.

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With primary ovarian insufficiency and not taking hrt, is it possible for a woman to get an occasional period?

With primary ovarian insufficiency and not taking hrt, is it possible for a woman to get an occasional period?

Kinda: If you have little to no estrogen from your ovaries you should not bleed at all. But if you have some in your diet or are overweight you may have bleeding so talk to your obgyn or endocrinologist.

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Is there something wrong with ovaries or hormone system if I have ovarian insufficiency?

Is there something wrong with ovaries or hormone system if I have ovarian insufficiency?

EARLY menopause: Ovarian failure or 'insufficiency' is a really another name for menopause (which may be premature if <40 yo). Normally the pituitary gland (in the brain) sends 2 hormone messengers FSH & lh to 'tell' the ovary to make estrogen/'female' hormones. When the ovary 'fails' =estrogen levels drop and fsh/lh levels rise confirming ovarian 'insufficiency' . Treatment with 'hormones' is optional.

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What is the treatment for ovarian insufficiency?

What is the treatment for ovarian insufficiency?

Trying to conceive?: If not trying to conceive: bone density scan, calcium, vitamin d, and hormone replacement with estrogen and progestin. We look for and treat any adrenal insufficiency. If you're trying to conceive, 5-10% of women with poi will get pregnant on their own after diagnosis, but if you truly have poi we don't have good fertility treatments using your own eggs. Egg donation or embryo donation are best.

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What is the definition or description of: Ovarian insufficiency?

What is the definition or description of: Ovarian insufficiency?

Spectrum of disorder: "Primary ovarian insufficiency describes a spectrum of declining ovarian functions and reduced fecundity due premature decrease in follicle number, an increase in follicle destruction or poor response to gonadotropins".This abnormal "Hypoestrogenic state" increases risks of vasomotor symptoms, urogenital atrophy, osteoporosis, fractures, cardiovascular diseases and other issues if left untreated

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Was planning to see classmates at upcoming 20th reunion. Now I am hearing my best friend has ovarian insufficiency. What is that?

Premature menopause: Ovarian insufficiency is another way of saying someone is going through menopause. There can be various causes of why someone might go through this prematurely. This can be treated with supplemental hormones and should not keep your friend from attending the reunion.

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What are the symptoms of ovarian insufficiency?

What are the symptoms of ovarian insufficiency?

Irregular/ no period: Irregular cycles or no periods, especially in a woman who was regular before, is a common sign. However there are many other causes of irregular cycles that we need to exclude. Hot flashes, vaginal dryness, or mood changes may occur, particularly if the woman's periods are stopped. Some women with primary ovarian insufficiency still have regular periods but see md for difficulty getting pregnant.

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Williams syndrome can u still work with this?

Williams syndrome can u still work with this?

genetic eval needed: Williams syndrome is a rare genetic condition that can affect many organ systems. It can affect the brain, heart an skeletal system. There are guidelines for what medical evaluations should be done on a annual basis. Talk to a geneticist to help coordinate care.

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How does williams syndrome affect a person's physical features?

How does williams syndrome affect a person's physical features?

William's Syndrome: Paraphrasing the national website (most young children with williams syndrome are described as having a small upturned nose, long philtrum (upper lip length), wide mouth, full lips, small chin, and puffiness around the eyes. They can also have a prominent "starburst" or white lacy pattern on their iris. Facial features become more apparent with age (see http://www.Williams-syndrome.Org/).

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What are the physical symptoms of a child with williams syndrome?

What are the physical symptoms of a child with williams syndrome?

Facial change murmur: Most have prominent lips, star like iris changes, eyebrow flare & skin fold over the inner corner of the eye. Growth is a bit slower than average as is head size. The aortic valve is often tight , producing a murmur. The great toe is often separated a bit from the rest of the toes.

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Does anyone have or know of any children out there with williams syndrome?

Does anyone have or know of any children out there with williams syndrome?

Have seen a couple: In three decades as a pediatrician, I have seen a couple. My first was during training & one in my practice.Most are felt to be caused by new mutations of one copy of chromosome 7. Years ago diagnosis was based on physical findings, today a gene test or "fish" test probe can be done on potential patients for confirmation.

Dr. Fred McCurdy
63 doctors shared insights

Williams Syndrome (Definition)

Neurodevelopmental disorder characterized by loquacious personality, abnormally sensitive hearing, supravalvular aortic stenosis, mental retardation, elfin facies, association with hypercalcemia due to abnormal sensitivity to vitamin d, idiopathic hypercalcemia of pregnancy. Due to deletion in elastin gene and probably several ...Read more


Dr. Seth Derman
115 doctors shared insights

Primary Ovarian Insufficiency (Definition)

Premature ovarian failure is a loss of normal function of your ovaries before age 40. If your ovaries fail, they don't produce normal amounts of the hormone estrogen ...Read more