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Doctor insights on: Primary Mediastinal Large B Cell Lymphoma

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Pathologic diagnosis....Resected thymus shows reactive b cell hyperplasia vs low grade b cell lympho proliferative disorder. Is this lymphoma?

Pathologic diagnosis....Resected thymus shows reactive b cell hyperplasia vs low grade b cell lympho proliferative disorder.  Is this lymphoma?

Could be...: Certain lymphomas grow so slow that sometimes it is difficult for the pathologist to make the call between malignant or not. I suspect they may do additional work on the specimen and that your doctor will evaluate you further with labs, additional scans or another biopsy. If you have not seen a hematologist, maybe this is the time. Don't panic, just follow up his/her lead. Best to you. ...Read more

Dr. Michael Thompson
1,760 doctors shared insights

Lymphoma (Definition)

A malignancy that develops in the lymph glands that causes nodes ...Read more


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Are lymphocyte rich hodgkin's lymphoma and nodular lymphocyte predominant hodgkin's lymphoma the same?

Are lymphocyte rich hodgkin's lymphoma and nodular lymphocyte predominant hodgkin's lymphoma the same?

Sometimes: Both ate classified as hodgkin but they can behave differetlny. Both are treated te same with chemo abvd regimen. Some new data suggest adding Rituxan (rituximab) if cd 20 positive in lymphocyte predominantly disease. ...Read more

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Which is worse, b cell lymphoma or t cell lymphoma?

Which is worse, b cell lymphoma or t cell lymphoma?

T-cell NHL: The prognosis for t-cell non-hodgkin's lymphoma (nhl) vs. B-cell nhl depends on multiple factors, but in general t-cell nhl has a worse prognosis. One reason is that b-cell, cd20+ nhl can be treated with the anti-cd20 monoclonal antibody Rituximab in addition to chemotherapy. We currently don't have such an effective, low toxicity antibody (biologic treatment) for t-cell nhl. ...Read more

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Is diffused b cell lymphoma genetic?

Not really: While there may be a genetic suscepibiltiy to developing lymphoma it is not truly a genetic disease. ...Read more

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What is the survival rate with large b cell lymphoma stage 4?

What is the survival rate with  large b cell lymphoma stage 4?

50%: However, there are numerous features about an individual lymphoma that point to worse or better survival for that individual. And survival is dependent on treatment as well; the use of the monoclonal antibody, rituximab, greatly impacts on survival. Finally, the medical community does not equate survival with cure, so we tend to talk about five year survival and ten year survival. ...Read more

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What is diffused b cell lymphoma?

Aggressive lymphoma: This is a type which is usually aggressive and can present at an advanced stage. Fortunately, the majority do respond well to modern chemotherapy regimens. A significant number relapse and require more therapy/ transplant. ...Read more

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Lul non small cell hilum region with lymph node involvement on pulmonary artery. Pet scan negative. Please stage.

Lul non small cell hilum region with lymph node involvement on pulmonary artery.  Pet scan negative.  Please stage.

Need more info: To completely stage, would need more information. However, lymph node involvement excluded stage 0 and stage i. If lymph nodes are on the same side as the hilar tumor, the tumor is at least 2 cm from the carina (where trachea divides into r and l main bronchi) and the tumor is 5 cm or smaller, it is stage iia. If tumor is 5-7 cm, and the rest true, it is stage iib. After that, it is complex! ...Read more

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Why does a person get large b cell type non hodgkins lymphoma?

Why does a person get large b cell type non hodgkins lymphoma?

There are no obvious: Causitive agents like there is for lung cancer. It doesn't tend to run in families most of the time either. Risk factors for developing it are increasing age, male sex (slightly more common ) and being white. It is uncommon in young females such as yourself, but not unheard of. ...Read more

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2 enlarged lymph nodes in the ant mediastinum, pet suv of abt 4.7, suspected thymoma nearby. Can this be lymphoma?

2 enlarged lymph nodes in the ant mediastinum, pet suv of abt 4.7, suspected thymoma nearby. Can this be lymphoma?

Depends on the size: You need to tell us what the ct scan shows in the mediastinum? Are the lymph nodes enlarged? What is their size? You need a follow up ct/pet scan in a couple of months, unless your lymph nodes are larger than 2cm size. Tell us more details. ...Read more

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Would small cell lung cancer in a mediastinal lymph node be classed as cancer of unknown primary if lung was clear on imaging.

Would small cell lung cancer in a mediastinal lymph node be classed as cancer of unknown primary if lung was clear on imaging.

SCLC arises next: to the bronchi and may not be visible on CT imaging in spite of the fact that it has already spread to a lymph node. Very rarely this same type of tumor arises in the prostate, cervix or gastrointestinal tract. Perhaps a sophisticated imaging technique such as PET scanning could detect the primary tumor in the lung, though knowing the type of tumor already can guide their treatment effectively. ...Read more

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Multiple enlarged axilla lymph nodes (largest is 2cm) normal chest xray.High Wbc. High absolute neutropolis.High lymphocytes. Lymphoma Cancer?

Multiple enlarged axilla lymph nodes (largest is 2cm) normal chest xray.High Wbc. High absolute neutropolis.High lymphocytes. Lymphoma Cancer?

Dont assume cancer: never make assumptions regarding cancer...you are right to be concerned and you should pursue further work-up...this will include a history and complete exam with possible further x-rays....the enlarged nodes could represent infection and not cancer...be prepared for biopsy to make final diagnosis ...Read more

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Do diffused large b cell lymphoma patients show symptoms of mental abnormalities?

Do diffused large b cell lymphoma patients show symptoms of mental abnormalities?

Maybe: In general we don't think of diffuse large b cell lymphoma (dlbcl) effecting brain function. However, many patients tell us of symptoms of a "fog" like feeling either before treatment (disease-related?) or after ("chemobrain"). Reasons are likely multifactorial and can include stress, financial concerns, depression, and disease biology. This is being actively studied by a variety of groups. ...Read more

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Had a CTA of Abdomen Retroperitoneal : Multiple sub pathologic lymph nodes the largest of which measures .68x.53cm. Lymph nodes reactive. Lymphoma?

Had a CTA of Abdomen Retroperitoneal :
Multiple sub pathologic lymph nodes the largest of which measures .68x.53cm. Lymph nodes reactive. Lymphoma?

Probably OK. : The nodes you mention do not meet criteria to be called abnormal at this point. That said... please follow up to ensure they don't get larger. Your doctor will order a scan in a few months. ...Read more

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Thymectomy done, thymus shows reactive b cell hyperplasia vs low grade bcell lympho proliferative disorder. What can it be? Is this serious? Treat?

No: Even if it's a low grade lymphoma if it's not anywhere else there's a good chance it will never come back. They should be able to tell from special tests of your thymus. Good luck. ...Read more

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What causes an inhomogeneous spleen in hodgkin lymphoma?

Lymphoma vs. other: The spleen in hl may be heterogeneous/inhomogeneous/non-uniform due to lymphoma involvement, spleen infarction (death) due to cancer death in the spleen, or infection, or "other". The radiologist may or may not be able to determine that and your oncologist might be able to say more about it with knowing the clinical history. ...Read more

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CTshows enlarged lymp nodes(Lower cervical/mediastinal and hiller); Also possible hepato-spleanomegaly-No discrete lesion.is this sarcoid or Lymphoma?

CTshows enlarged lymp nodes(Lower cervical/mediastinal and hiller); Also possible hepato-spleanomegaly-No discrete lesion.is this sarcoid or Lymphoma?

Mgt: The CT report and image may be uploaded during a virtual consult to better assist, but from your description many possible conditions are possible. EBUS biopsy is one way to determine the cause. A TB test and blood work may also be indicated. ...Read more