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Doctor insights on: Primary Lateral Sclerosis In Children

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What is primary lateral sclerosis?

What is primary lateral sclerosis?

Variation of ALS: Motor neuron disease or ALS presents in several variable forms, and is a disease of motor neuron degeneration in brain and spinal cord. In the primary lateral sclerosis variant (only 1-3% of all cases), the disorder affects the upper motor neuron only, and is focal on one side or the other. By definition, this form would be far less malignant. ...Read more

Dr. Neigatha Graney
25 Doctors shared insights

Primary Lateral Sclerosis (Definition)

Motor neuron disease or ALS presents in several variable forms, and is a disease of motor neuron degeneration in brain and spinal cord. In the primary lateral sclerosis variant (only 1-3% of all cases), the disorder affects the upper motor neuron only, and is focal on one side or the other. By definition, this form would ...Read more


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What are the symptoms of primary lateral sclerosis?

What are the symptoms of primary lateral sclerosis?

Variant of ALS: Als affects motor nerve cells, but varies in presentation. Diagnosis of primary lateral sclerosis is challenging, as involves upper motor neuron cells and early on, an EMG test could well be non-diagnostic, as it tests the lower cells. Since this variation involves central corticospinal cells, there is unilateral weakness of arm and/or leg without sensory loss. Later, loss of muscle bulk maybe. ...Read more

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Primary lateral sclerosis only 1 side, is this normal?

Primary lateral sclerosis only 1 side, is this normal?

Not unexpected: Not surprising but this may not stay unilateral, or this may be the ultimate outcome. Motor neuron disorders vary in expression, but require attentive followup with a neuromuscular specialist on an ongoing basis. Riluzole may be of value. ...Read more

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What is the definition or description of: primary lateral sclerosis?

What is the definition or description of: primary lateral sclerosis?

Variation of ALS: Motor neuron disease or ALS presents in several variable forms, and is a disease of motor neuron degeneration in brain and spinal cord. In the primary lateral sclerosis variant (only 1-3% of all cases), the disorder affects the upper motor neuron only, and is focal on one side or the other. By definition, this form would be far less malignant. ...Read more

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I am suffering from primary lateral sclerosis, is there a treatmnet?

Yes there is: Primary lateral sclerosis is a form of lou gehrig's disease, which affects the motor neuron cell, and may involve a slow chronic course. The drug Riluzole is the only product on the market so far, and has shown some potential to prevent tracheostomy. Part of the treatment involves supportive care, and prevention of infections, so work closely with a team of experienced physicians. ...Read more

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Can you tell me if emg tests can be normal with primary lateral sclerosis?

Can you tell me if emg tests can be normal with primary lateral sclerosis?

Would be unlikely: If motor neuron disease exists, and could be in form of primary lateral sclerosis, there will usually be some degree of EMG pathology. A fully normal EMG would tend to rule against a diagnosis of any kind of motor neuron disease, but early on, findings might be very minimal and the test might need repetition in several months. ...Read more

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Treatment for upper motor neuron sympathy for my diagnose of primary lateral sclerosis?

Treatment for upper motor neuron sympathy for my diagnose of primary lateral sclerosis?

Try this: Although no cure currently, the drug Riluzole has been used to slow down the process and prevent or delay tracheostomy. Some pts might benefit from other glutamate blockers, Gabapentin and memantine have been tried in addition. Some alternative health sites have mentioned anti-oxidant approaches, and you might check hsi (health science institute). Get second opinion at nearby medical schools. ...Read more

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I have been diagnosed with primary lateral sclerosis by my neurologist here in savannah. What's the chance of mine changing to als? Really concerned.

Unlikely: Although primary lateral sclerosis can be disabling, it is no where near as bad as als. You shouldn't be thinking about that but how you can best follow your neuologists instructions to get better. ...Read more

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How much time does it take to loose legs arms speaking if they tell ya primary lateral sclerosis?

How much time does it take to loose legs arms speaking if they tell ya primary lateral sclerosis?

Variable, but: Many pts succumb within 5-10 yrs at most. Others may rapidly lose function over just several months to 1 or 2 years. No magic formula, but Riluzole can delay deterioration for at least 6-9 months or more. ...Read more

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Can someone with multiple sclerosis have children?

Can someone with multiple sclerosis have children?

Depends on situation: I have one wonderful mom whose 3 kids (all after ms dx) are just wonderful. ...Read more

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What do you consider primary symptoms of multiple sclerosis?

What do you consider primary symptoms of multiple sclerosis?

Classical: Loss of vision unilaterally, loss of balance and coordination, weakness of both legs, or focal arm/leg weakness, electrical shock sensation from neck downwards, unexplained fatigue or cognitive loss, problems with bladder control. All of this varies greatly from patient to patient as NO MS pt is similar to another. ...Read more

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It is possible that a man with multiple sclerosis have children?

It is possible that a man with multiple sclerosis have children?

Yes.: Male fertility does not appear to be impaired in ms, although some men may have problems with impotence or ejaculatory dysfunction that interfere with conception. These problems are amenable to a variety of therapeutic strategies, including medication for erectile dysfunction, artificial insemination, and electronic ejaculatory stimulation. ...Read more

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Is primary progessive multiple sclerosis always fatal?

Is primary progessive multiple sclerosis always fatal?

Not necessarily: Ms has been said to shorten life span, and untreated this is correct, but several studies have supported normal life if appropriate potent meds are employed. Primary progressive ms does not respond well to the usual meds, and mostly symptomatic interventions are used. There are many research projects nowadays, and best to contact a medical school and get involved. ...Read more

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What is amyotrophic lateral sclerosis (als)?  

Motor neuron disease: A disorder of misfolded proteins, attacking nerve cell bodies in spinal cord and brain. Tends to involve weakness not numbness, and can affect legs and arms with flickering of muscles, loss of muscle mass, and evenually problems with breathing and swallowing. Unfortunately, there is no cure, and it preserves awareness. Gratefully, it is relatively rare. ...Read more

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Who first discovered amyotrophic lateral sclerosis?

Who first discovered amyotrophic lateral sclerosis?

Charcot: The French Neurologist Charcot is credited with the paper describing ALS as a distinct illness ...Read more

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What are the tests for amyotrophic lateral sclerosis?

Diagnosis: Since we hope to find alternative problems instead of als, we search for possible other diagnoses. The testing includes blood studies, especially for hyperthyroidism, MRI tests of the neck and spinal cord, EMG studies, and even muscle biopsies on occasion. ...Read more

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What sort of problem is amyotrophic lateral sclerosis?

Lou Gehrig's: Als also known as lou gehrig's disease is a disease of nerves. It is a progressive loss of muscle strength. Initial symptoms are usually muscle weakness or cramps followed by muscle paralysis in later stages. Difficulty breathing and swallowing are common due to the muscle weakness. There is no cure but there are medications to help with symptom management. ...Read more

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What are the symptoms of amyotrophic lateral sclerosis?

What are the symptoms of amyotrophic lateral sclerosis?

See below: The main symptoms of ALS are weakness. The weakness often starts with one hand and then may progress to the other. The legs will often become weak as well. The muscles begin to get thinner. This is called atrophy. There may also be exaggerated reflexes and stiffness in the muscles called spasticity. The muscles that help us speak and swallow and breath can also be weakened. ...Read more

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How is amyotrophic lateral sclerosis transmitted in humans?

It is not transmitte: It is not typically a heriditary or infectious disease. No one knows the exact cause. ...Read more

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Hi doctors, was just wondering what is amyotrophic lateral sclerosis?

Lou Gehrig's disease: Als is a very nasty uncurable disease involving the motor neuron in brain and spinal cord, usually arising in middle to later years of life. It results in a steady deterioration of muscle, with atrophy and fasciculations, possibly eventuating in loss of ability to swallow and breathe. The sole medication on the market which may modestly help is riluzole. ...Read more

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What is the treatment for amyotrophic lateral sclerosis?

What is the treatment for amyotrophic lateral sclerosis?

Not good: Lou gehrig's disease remains resistant to successful treatment or control. The drug Riluzole is on the market but is very disappointing, although may delay useage of a tracheostomy tube for a few months. We are learning about a misfolded protein, and this may point the way for future success. ...Read more

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A friend of mine was recently diagnosed with primary progressive multiple sclerosis. Is this a fatal disease?

A friend of mine was recently diagnosed with primary progressive multiple sclerosis. Is this a fatal disease?

Cannot predict: Primary progressive ms is typically without rapid relapses, but also, without remission. Does not seem to respond well to meds employed in relapsing/remitting form. Most active therapy is symptomatic. However, research is ongoing with Gilenya (fingolimod) for ppms. Other drugs not yet on the market are being studied. Best bet is to get into one of these studies. Contact local medical school. Stay positive. ...Read more

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What is amyotrophic lateral sclerosis?

Disease of nervecell: Amyotrophic lateral sclerosis, or als, is a disease of the nerve cells in the brain and spinal cord that control voluntary muscle movement. Als does not affect the senses (sight, smell, taste, hearing, touch). It only rarely affects bladder or bowel function, or a person's ability to think or reason. The condition slowly gets worse and cause difficulty with breathing muscles. ...Read more

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Could kids get amyotrophic lateral sclerosis?

Could kids get amyotrophic lateral sclerosis?

Similar: But most childhood illnesses which affect the motor neuron, like als, are quite rare, and more hereditary in origin. A variety of such disorders cause weakness in very young children, and adolescents and seem similar in outcome. Also, polio used to affect many children but is almost unknown in usa today. ...Read more

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What exactly is amyotrophic lateral sclerosis?

What exactly is amyotrophic lateral sclerosis?

Lou Gehrig's disease: Als is a disease affecting the nerve cell body, causes weakness, muscle wasting, and fasciculations or fluttering of the muscles. It can affect mobility, swallowing, and breathing. There is no known cure to date, and the prognosis is often very poor. We believe it is a disorder of "misfolded proteins", similar in some ways to alzheimer's and parkinson's, but a far rarer condition, fortunately. ...Read more

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What is amyotrophic lateral sclerosis (als)? Can it be treated?

Lou Gehrig's disease: Als is a disease affecting the nerve cell body, causes weakness, muscle wasting, and fasciculations or fluttering of the muscles. It can affect mobility, swallowing, and breathing. There is no known cure to date, and the prognosis is often very poor. We believe it is a disorder of "misfolded proteins", similar in some ways to alzheimer's and parkinson's, but a far rarer condition, fortunately. ...Read more

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What are the challenges of living with amyotrophic lateral sclerosis?

Very difficult: ALS is a progressive nasty disease with NO cure or even significant control other than Riluzole, and causes muscular atrophy, weakness, fasciculations, and eventual inability to swallow or breathe. As you can imagine, these problems require extensive medical care and diligence, and interventions which may be very complex. ...Read more

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What is the definition or description of: Amyotrophic lateral sclerosis?

Neurodegenerative: ALS is a neurodegenerative disease of the upper and lower motor neurons. There is a male predominance, and occurs most frequently between the ages of 50 - 60 years. While the most frequent form has a dire prognosis, it does have several variants, with different prognoses that can be prolonged with respect to survival. The diagnosis is based on the clinical findings and robust NCV/EMG studies. ...Read more

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Last advances in the investigation on amyotrophic lateral sclerosis?

Research still slow: A number of established agents have recently been investigated for their potential as neuroprotective agents, including antibiotics and minocycline. Progress has also been made in exploiting growth factors for the treatment of amyotrophic lateral sclerosis, partly due to advances in developing effective delivery systems to the central nervous system but overall out looks so far is not great yet. ...Read more

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My mom has amyotrophic lateral sclerosis. (lou gehrigs). What is this exactly?

Bad disease: ALS damages the motor nerve cell in brain and spinal cord causing progressive arm and leg weakness, muscle flickering, with progressive disability. If the disease affects the lower part of the brain, problems with tongue atrophy, swallowing, and breathing can create major crises, and even need for tracheostomy. The sole available drug, Riluzole does delay trach, but no effect on strength. ...Read more

Dr. Ronald Krauser
3 Doctors shared insights

Sclerosis (Definition)

We neurologists employ the term to describe localized damage involving the central nervous system, and sclerosis means scarring. If in many areas, might be multiple sclerosis. If affecting the motor nerve cell, ...Read more