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Doctor insights on: Primary Lateral Sclerosis

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Dr. Daniel Saurborn
24 doctors shared insights

Primary Lateral Sclerosis (Overview)

Motor neuron disease or ALS presents in several variable forms, and is a disease of motor neuron degeneration in brain and spinal cord. In the primary lateral sclerosis variant (only 1-3% of all cases), the disorder affects the upper motor neuron only, and is focal on one side or the other. By definition, this form would be far less malignant.


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What is the definition or description of: primary lateral sclerosis?

What is the definition or description of: primary lateral sclerosis?

Variation of ALS: Motor neuron disease or ALS presents in several variable forms, and is a disease of motor neuron degeneration in brain and spinal cord. In the primary lateral sclerosis variant (only 1-3% of all cases), the disorder affects the upper motor neuron only, and is focal on one side or the other. By definition, this form would be far less malignant. ...Read more

Dr. Daniel Saurborn
24 doctors shared insights

Primary Lateral Sclerosis (Overview)

Motor neuron disease or ALS presents in several variable forms, and is a disease of motor neuron degeneration in brain and spinal cord. In the primary lateral sclerosis variant (only 1-3% of all cases), the disorder affects the upper motor neuron only, and is focal on one side or the other. By definition, this form would be far less malignant.


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What is primary lateral sclerosis?

What is primary lateral sclerosis?

Variation of ALS: Motor neuron disease or ALS presents in several variable forms, and is a disease of motor neuron degeneration in brain and spinal cord. In the primary lateral sclerosis variant (only 1-3% of all cases), the disorder affects the upper motor neuron only, and is focal on one side or the other. By definition, this form would be far less malignant. ...Read more

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What are the symptoms of primary lateral sclerosis?

What are the symptoms of primary lateral sclerosis?

Variant of ALS: Als affects motor nerve cells, but varies in presentation. Diagnosis of primary lateral sclerosis is challenging, as involves upper motor neuron cells and early on, an EMG test could well be non-diagnostic, as it tests the lower cells. Since this variation involves central corticospinal cells, there is unilateral weakness of arm and/or leg without sensory loss. Later, loss of muscle bulk maybe. ...Read more

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Treatment for upper motor neuron sympathy for my diagnose of primary lateral sclerosis ?

Treatment for upper motor neuron sympathy  for my diagnose of primary lateral  sclerosis ?

Try this: Although no cure currently, the drug Riluzole has been used to slow down the process and prevent or delay tracheostomy. Some pts might benefit from other glutamate blockers, Gabapentin and memantine have been tried in addition. Some alternative health sites have mentioned anti-oxidant approaches, and you might check hsi (health science institute). Get second opinion at nearby medical schools. ...Read more

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Can you tell me if emg tests can be normal with primary lateral sclerosis?

Can you tell me if emg tests can be normal with primary lateral sclerosis?

Would be unlikely: If motor neuron disease exists, and could be in form of primary lateral sclerosis, there will usually be some degree of EMG pathology. A fully normal EMG would tend to rule against a diagnosis of any kind of motor neuron disease, but early on, findings might be very minimal and the test might need repetition in several months. ...Read more

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Primary lateral sclerosis only 1 side, is this normal?

Primary lateral sclerosis only 1 side, is this normal?

Not unexpected: Not surprising but this may not stay unilateral, or this may be the ultimate outcome. Motor neuron disorders vary in expression, but require attentive followup with a neuromuscular specialist on an ongoing basis. Riluzole may be of value. ...Read more

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What is primary lateral sclerosis?

Variation of ALS: Motor neuron disease or ALS presents in several variable forms, and is a disease of motor neuron degeneration in brain and spinal cord. In the primary lateral sclerosis variant (only 1-3% of all cases), the disorder affects the upper motor neuron only, and is focal on one side or the other. By definition, this form would be far less malignant. ...Read more

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What are the symptoms of primary lateral sclerosis?

Variant of ALS: Als affects motor nerve cells, but varies in presentation. Diagnosis of primary lateral sclerosis is challenging, as involves upper motor neuron cells and early on, an EMG test could well be non-diagnostic, as it tests the lower cells. Since this variation involves central corticospinal cells, there is unilateral weakness of arm and/or leg without sensory loss. Later, loss of muscle bulk maybe. ...Read more

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What is the definition or description of: primary lateral sclerosis?

Variation of ALS: Motor neuron disease or ALS presents in several variable forms, and is a disease of motor neuron degeneration in brain and spinal cord. In the primary lateral sclerosis variant (only 1-3% of all cases), the disorder affects the upper motor neuron only, and is focal on one side or the other. By definition, this form would be far less malignant. ...Read more

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I am suffering from primary lateral sclerosis, is there a treatmnet?

Yes there is: Primary lateral sclerosis is a form of lou gehrig's disease, which affects the motor neuron cell, and may involve a slow chronic course. The drug Riluzole is the only product on the market so far, and has shown some potential to prevent tracheostomy. Part of the treatment involves supportive care, and prevention of infections, so work closely with a team of experienced physicians. ...Read more

Sclerosis (Definition)

We neurologists employ the term to describe localized damage involving the central nervous system, and sclerosis means scarring. If in many areas, might be multiple sclerosis. If affecting the motor nerve cell, ...Read more