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Doctor insights on: Pregnenolone Vs Dhea

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Is it ever safe to take dhea or pregnenolone without first testing hormone balances in a lab?

Is it ever safe to take dhea or pregnenolone without first testing hormone balances in a lab?

Hormone replacement: Its never a good idea to take a hormone as a supplement unless there is a deficiency. Even in some hormone deficiencies, the drawbacks to replacement outweigh the benefits. While there is some limited evidence that dhea replacement can help specific groups (people with addison's disease for example), I am unaware of evidence for pregnenolone replacement. Endocrinologists have this knowledge.

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Dr. Krishna Kumar
27 Doctors shared insights

Pregnenolone (Definition)

Is a steroid hormone made in the body from cholesterol: its is a direct precursor hormone for Progesterone and 17oh-p, and so is a building block for all androgens and estrogens. Mineralocorticoid hormones are ...Read more


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Taking estrogen, progesterone, and testosterone is known to be a risk factor for causing blood clots. Is the same true of pregnenolone and dhea?

Taking estrogen, progesterone, and testosterone is known to be a risk factor for causing blood clots. Is the same true of pregnenolone and dhea?

Unknown, probably no: Supplements such as dhea and pregnenolone are not regulated by the fda and have no good studies that demonstrate that they do anything beneficial for any medical condition. The safety of these supplements is also unknown. You appear to be very young to have to be on hormone supplements. You should see an endocrinologist to find out if you really need to be on them.

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What does high dheas mean?

Male hormone: DHEAS is a weak androgen (male hormone) produced by your adrenal gland. Excess levels can cause abnormal hair growth and problems with ovulation. You need to discuss this with your MD.

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Is it bad to have high dhea?

Some: There are many effective treatments see an OB/GYN are endocrinologist

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What exactly is natural dhea?

Dangerous: Its not regulated and ive seen many people feel better for a while then much worse. There are many natural poisons out there.

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Which types of foods contain dhea?

None: Some foods like wild yam and soybeans contain raw ingredients for dhea but do not contain dhea itself. We don't know if eating more soybeans increases your dhea.

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What exactly is the function of dhea?

What exactly is the function of dhea?

Prohormone: Dhea is one of the adrenal hormones. It is most noted for help with short term memory. It also helps with the production of Estradiol (estrogen) and testosterone. And it is noted to help with boosting the immune system.

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Does lowering of dhea has any effects?

Dhea: Yes as this will change the balance and equilibrium of other hormones e.g. Testosterone, estrogen, Progesterone etc.

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Are there benefits of a woman using dhea?

Are there benefits of a woman using dhea?

Yes, if deficient: Suboptimal levels of dhea are common in those with adrenal insufficiency, a common condition in those with ongoing stress. However, dhea is converted to estrogen & testosterone & can be dangerous in high doses. I advise taking 5-10 mg, ideally under medical supervision, as part of a larger program to restore adrenal health- see www. Womentowomen. Com/adrenalhealth/dhea-naturalandsupplementation. Aspx.

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What are the benefits of women using dhea?

Benefit: Science suggests that if deficient, replacement can improve libido and depression in women.

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What is dheas & its effects on female body?

What is dheas & its effects on female body?

No: Dhea is metabolized to cortisone, estrogen and testosterone -- and you can't control which one is goes to. Also, there is no medical indication to take it in the first place, and most of the dhea supplements have little dhea in them. Don't get your medical advice from tv or the internet!

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What are the differences between dhea and 7-keto?

The branding...: These 2 compounds are basically similar; and some even come in the same formulation/powder; so you can make shakes from it to enhance your workouts. Companies like twin-labs; now foods, etc. All have their own...And my sage advice on questions like this is let the buyer beware! Always ask your doctor before starting any new medication/supplement!

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Can dhea boost your energy?

Doubt it: Dhea has been used for many things: increase libido, increase hair and increase energy. The studies are not too convincing. I doubt it.

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Is dhea in a feedback loop?

Is dhea in a feedback loop?

While ACTH: Can stimulate dhea production, the exact mechanism of dhea regulation is unknown. Beware of junk you read on the internet re: dhea and it's significance in medical disease or use as a therapy. It is metabolized to estrogen, testosterone or cortisone -- and you can't control which it's converted into. Stay away from dhea supplements, most don't have much active ingredient anyway.

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Is it dangerous to take dhea?

Is it dangerous to take dhea?

Not really: For the general population the answer is no. If you have any kind of hormonal imbalance then you would want to check with your doctor 1st. More important is why would you want to take it? For men it mostly can cause breast enlargement and higher levels of estradiol, a female hormone.

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Does dhea raise bloodpressure?

Does dhea raise bloodpressure?

Most "DHEA": Pills don't have much dhea in them. Even if they did, it's not an approved treatment for any medical problem. Dhea is metabolized to estrogen, testosterone or cortisone -- and you can't choose which it goes to -- so yes, it can cause problems, including blood pressure elevation.

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Can someone be allergic to dhea?

Can someone be allergic to dhea?

Unlikely: Dhea is a natural product produced in our body. Unlikely you would be allergic to it. If you are taking dhea supplements, it is likely you are reacting to some preservative or component of the capsule used to manufacture the product.

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Will dhea convert into estrogen?

Will dhea convert into estrogen?

Yes: Dhea is a male-type (androgenic) hormone from the adrenal glands which can be enzymatically converted to other androgens in your body, which can be converted to Estrogens by the hormone aromatase. Beware of marketing excesses that imply benefits from supplements which are unproven.

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Dhea (Definition)

Dhea= dihydroepiandrosterone ...Read more