Doctor insights on:
Pregnenolone Half Life
No association: No association I am aware of with Alzheimer's disease. ...Read more
Specific & limited: Pregnenolone is an adrenal hormone made from cholesterol, and is the pre-cursor for sex-steroid hormones. It is said to 'improve mood, ' but no strong data support. To my knowledge there is no role for it's use as a supplement. Aromatase inhibitors are for treatment of some breast cancers; they're also used off-label for ovulation induction in women. No other appropriate uses to my knowledge. ...Read more
Unknown effects: Rises in luteal phase of the cycle along with progesterone. As far as we know, it is simply a precursor to progesterone. It has risen in popularity in hormone replacement circles that are somewhat heavy on the till for hormones. It is a "new" way, supposedly to give people higher Progesterone levels but has never been studied and no one knows the true effects. Would stay away until know more. ...Read more
Paxil/Proges.: Each has its own side-effect profile, but mixing the two should not cause interference with one another. ...Read more
Arts and crafts: The cotton (or cotton-like material) in a bottle of pills fills up the extra space in the bottle, helping to prevent the pills from tossing around during shipping. This keeps the outer surface of the pills in good condition. A patient can use the cotton to make arts and crafts, or if worried about medicine residue on the cotton, can just toss it into the trash. ...Read more
Could be: Could be a sign of congenital adrenal hyperplasia with one of several enzyme defects. This is rare. Depends on who's ordering the test. If endocrinology, this is the reason. Adrenal fatigue is a popular diagnosis now but really represents metabolic stress and is a reaction of the system to stress. The answer is not to address the symptom of the stress but to address the stress itself. ...Read more
Could there be a correlation that would explain elevated ptt, high ALDO/PRA RATIO, low pregnenolone and elevated AFP?
I'm young with low t, trying to find the cause should I get my e2, prolaktin, progesterone and maybe my pregnenolone due to bodybuilding carrier. Thanks!
Bodybuilding: Your question is written with some ambiguity, but why would you be surprised to have low t if you are taking any product for body building? Taking products for body building is extremely dangerous (regardless of what you read on the internet or what your body building buddies maintain). It is not wise. It is dangerous and I would recommend you stop testing and stop the product and pray. ...Read more
Hormone replacement: Its never a good idea to take a hormone as a supplement unless there is a deficiency. Even in some hormone deficiencies, the drawbacks to replacement outweigh the benefits. While there is some limited evidence that dhea replacement can help specific groups (people with addison's disease for example), I am unaware of evidence for pregnenolone replacement. Endocrinologists have this knowledge. ...Read more
Can certain things increase REM sleep, such as melatonin or pregnenolone? Academic interest for the most part.
Need serious answers-any dangerous reactions between Norvasc (amlodipine) 5mg and reacted multimineral, phosphatidylserine, pregnenolone, adren-all? Thank you.
I checked: No interactions have been reported (but probably those chemicals haven't been studied, either, since they're not commonly used together). ...Read more
For me, pregnenolone = a powerful mood stabilizer, antidepressant, anxiolytic & sensory sensitivity reducer. What could this mean? Adrenal issue?
Intriguing: There are some early research studies that suggest that pregnenalone may indeed do what you're describing. It's too early to consider it a psychiatric drug for anxiety and mood disorders. But who knows what the next year or two might uncover. (to prove absolutely that it is not an adrenal issue will require some blood work ordered by your doc. ...Read more
Taking estrogen, progesterone, and testosterone is known to be a risk factor for causing blood clots. Is the same true of pregnenolone and dhea?
Unknown, probably no: Supplements such as dhea and pregnenolone are not regulated by the fda and have no good studies that demonstrate that they do anything beneficial for any medical condition. The safety of these supplements is also unknown. You appear to be very young to have to be on hormone supplements. You should see an endocrinologist to find out if you really need to be on them. ...Read more
Dangerous reactions between Norvasc (amlodipine) 5 mg, and reacted multimineral, phosphatidylserine, pregnenolone, adren-all? Plz help! I'm on these for adrenal fatigue
Do you have adrenal: Insufficiency? The goal in ai is to offer appropriate hormone replacement that closely mimic physiologic conditions. Do you have central, primary or secondary disease? Treatment is glucocorticoids (hydrocortisone, prednisone, dexamethasone) and in primary ai you add Fludrocortisone a mineralocorticoid. I do not see a problem between the use of amlodipine and the above meds just mention. ...Read more
What pituitary hormones cause the adrenal gland to produce mineralocorticoids, glucocorticoids, and androgens and estrogens including pregnenolone?
Pituitary & steroids: Hi. Pituitary ACTH regulates adrenal cortisol production; it also acutely stimulates aldosterone, but is not the principle regulator. LH principally stimulates gonadal steroid hormone production (both genders make androgens & estrogens, but in opposite dominance). Pregnenolone is early in the steroidogenic pathway in both adrenals and gonads. Good luck! ...Read more
Is pregnenolone supp. Safe? I think I am low on progesterone- can't sleep, anxiety, fast pulse, migraines and tender breasts- partial hyster. 2007
Family Practice: Do not experiment on yourself. It is not safe without a dr's supervision. ...Read more
If I am taking propecia (finasteride) for hair loss, is it good or bad to take pregnenolone at the same time? Had brain fog while taking propecia (finasteride)...Not anymore
Could low dhea sulfate or low pregnenoone levels cause your heart rate to increase with excertion heart test are normal echo stress test?
Not likely: Likely a component of deconditioning. See your doctor for evaluation. ...Read more
Live HealthyLiveLong: I tell my patients if they want to live long, they have to lead a healthy life. It includes proper nutrition, avoid over eating and eat the right kind of food. Do not Smoke. If you drink, drink in moderation.Exercise regularly. Have a good night sleep, Avoid Stress and laugh a lot. Practice safe sex.Get regular check ups and screening for certain diseases like cancer, diabetese and others. And hope for best ...Read more
Yes: If you are worried about doing to much worrying then the conclusion would be you are worrying too much. Some worry is productive like carrying an umbrella when it looks like rain but constant worry keeps us from being as happy and productive as we could be without the overwhelming anxiety. Don't keep troubles inside-talk to someone and leave the umbrella at home when the sun is out. ...Read more
2B brave act brave: Nobody is going to reach out to you to make your life better. Nobody owes you happiness or fulfillment. You must take appropriate initiative. If you're old enough to be writing, you can walk away from a difficult past. Stop doing the things that waste your time, join an activity where you are likely to meet someone, learn a new marketable skill, be a diplomat & learn to enjoy your own company. ...Read more