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Doctor insights on: Pregnenolone

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Dr. Dariush Saghafi
27 doctors shared insights

Pregnenolone (Overview)

Is a steroid hormone made in the body from cholesterol: its is a direct precursor hormone for Progesterone and 17oh-p, and so is a building block for all androgens and estrogens. Mineralocorticoid hormones are also made from pregnenolone.


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What's pregnenolone augmentation?

What's pregnenolone augmentation?

Pregnenolone: Pregnenolone (preg) is a neurosteroid, which displays multiple effects on the central nervous system, and may be beneficial in the treatment of cognitive and negative symptoms in patients with schizophrenia, as well as cognitive symptoms in mood disorders as well as ptsd. ...Read more

Dr. Dariush Saghafi
27 doctors shared insights

Pregnenolone (Overview)

Is a steroid hormone made in the body from cholesterol: its is a direct precursor hormone for Progesterone and 17oh-p, and so is a building block for all androgens and estrogens. Mineralocorticoid hormones are also made from pregnenolone.


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Is it safe for Paxil (paroxetine) and pregnenolone to be taken at the same time?

Is it safe for Paxil (paroxetine) and pregnenolone to be taken at the same time?

Paxil/Proges.: Each has its own side-effect profile, but mixing the two should not cause interference with one another. ...Read more

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What's a good resource for trace elements and heavy metal toxicity?

What's a good resource for trace elements and heavy metal toxicity?

Be VERY careful: Most of the outfits offering "heavy metal testing" are scams, charging outrageous prices for"tests" intended to get you to buy their nutritional supplements, have your fillings removed, and generally suck you into a expensive racket. They exude warmth and this is the one thing that may make you feel better. ...Read more

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What are benefits of pregnenolone?

What are benefits of pregnenolone?

Doubtful: Pregnenolone is a natural adrenal hormone made from cholesterol, and is the pre-cursor for sex-steroid hormones. It is said to 'improve mood, ' but no worthwhile data support. To my knowledge there is no role for it's use as a supplement. ...Read more

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For me, pregnenolone = a powerful mood stabilizer, antidepressant, anxiolytic & sensory sensitivity reducer. What could this mean? Adrenal issue?

For me, pregnenolone = a powerful mood stabilizer, antidepressant, anxiolytic & sensory sensitivity reducer. What could this mean? Adrenal issue?

Intriguing: There are some early research studies that suggest that pregnenalone may indeed do what you're describing. It's too early to consider it a psychiatric drug for anxiety and mood disorders. But who knows what the next year or two might uncover. (to prove absolutely that it is not an adrenal issue will require some blood work ordered by your doc. ...Read more

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High pregnenolone levels and low aldosterone levels, is this a bad hormone problem?

High pregnenolone levels and low aldosterone levels, is this a bad hormone problem?

Could be: Could be a sign of congenital adrenal hyperplasia with one of several enzyme defects. This is rare. Depends on who's ordering the test. If endocrinology, this is the reason. Adrenal fatigue is a popular diagnosis now but really represents metabolic stress and is a reaction of the system to stress. The answer is not to address the symptom of the stress but to address the stress itself. ...Read more

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When does pregnenolone increase?

When does pregnenolone increase?

Late in cycle: Pregnenolone will mirror the levels of Progesterone as it it a precursor. Therefore it will rise in the luteal phase of the menstrual cycle with progesterone. ...Read more

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What's pregnenolone augmentation?

Pregnenolone: Pregnenolone (preg) is a neurosteroid, which displays multiple effects on the central nervous system, and may be beneficial in the treatment of cognitive and negative symptoms in patients with schizophrenia, as well as cognitive symptoms in mood disorders as well as ptsd. ...Read more

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What are benefits of pregnenolone?

Doubtful: Pregnenolone is a natural adrenal hormone made from cholesterol, and is the pre-cursor for sex-steroid hormones. It is said to 'improve mood, ' but no worthwhile data support. To my knowledge there is no role for it's use as a supplement. ...Read more

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What to do if I think I'm pregnenolone?

Can you clarify?: Pregnenolone is a hormone. If you think you are pregnant, please get with your personal physician. This is privileged if you are underage and at least where I live, the physician cannot inform your parents / family. ...Read more

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Why does pregnenolone change; what does it do?

Why does pregnenolone change; what does it do?

Luteal Phase: Rises in luteal phase of the cycle along with progesterone. As far as we know, it is simply a precursor. ...Read more

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What is the definition or description of: pregnenolone?

What is the definition or description of: pregnenolone?

Pregnenolone: Is a steroid hormone made in the body from cholesterol: its is a direct precursor hormone for Progesterone and 17oh-p, and so is a building block for all androgens and estrogens. Mineralocorticoid hormones are also made from pregnenolone. ...Read more

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Pregnenolone and aromatase blocker uses?

Pregnenolone and aromatase blocker uses?

Specific & limited: Pregnenolone is an adrenal hormone made from cholesterol, and is the pre-cursor for sex-steroid hormones. It is said to 'improve mood, ' but no strong data support. To my knowledge there is no role for it's use as a supplement. Aromatase inhibitors are for treatment of some breast cancers; they're also used off-label for ovulation induction in women. No other appropriate uses to my knowledge. ...Read more

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Has anyone been using pregnenolone? Does it have lots of hormonal effects or side effects?

Has anyone been using pregnenolone?  Does it have lots of hormonal effects or side effects?

Unknown effects: Rises in luteal phase of the cycle along with progesterone. As far as we know, it is simply a precursor to progesterone. It has risen in popularity in hormone replacement circles that are somewhat heavy on the till for hormones. It is a "new" way, supposedly to give people higher Progesterone levels but has never been studied and no one knows the true effects. Would stay away until know more. ...Read more

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Is it safe for Paxil (paroxetine) and pregnenolone to be taken at the same time?

Paxil/Proges.: Each has its own side-effect profile, but mixing the two should not cause interference with one another. ...Read more

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Hurry what am i supposed to do with the cotton in pregnenolone supplement bottle?

Hurry what am i supposed to do with the cotton in pregnenolone supplement bottle?

Arts and crafts: The cotton (or cotton-like material) in a bottle of pills fills up the extra space in the bottle, helping to prevent the pills from tossing around during shipping. This keeps the outer surface of the pills in good condition. A patient can use the cotton to make arts and crafts, or if worried about medicine residue on the cotton, can just toss it into the trash. ...Read more

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High pregnenolone levels and low aldosterone levels, is this a bad hormone problem?

Could be: Could be a sign of congenital adrenal hyperplasia with one of several enzyme defects. This is rare. Depends on who's ordering the test. If endocrinology, this is the reason. Adrenal fatigue is a popular diagnosis now but really represents metabolic stress and is a reaction of the system to stress. The answer is not to address the symptom of the stress but to address the stress itself. ...Read more