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Doctor insights on: Prednisone Joints Bone

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Dr. Thomas Namey
2,568 Doctors shared insights

Prednisone (Definition)

Prednisone is a synthetic cortisone. The body makes cortisone, a natural hormone made in adrenal glands. The body converts it to Hydrocortisone to become active. 25 mg of cortisone has about same effect as 5 mgm prednisone. The average person would produce 3-6 mg of pred daily. So why use a substitute? The synthetic has more anti-inflammatory effect; but has less effect ...Read more


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How fast oral prednisone work on joint pain?

How fast oral prednisone work on joint pain?

Usually within a day: Or earlier. But consequences and side-effects emerge with too much for too long. A quick fix, but usually not the long term one! Especially for arthritis! ...Read more

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My joints are hurting. Just the normal prednisone side effects. Will this end?

My joints are hurting. Just the normal prednisone side effects. Will this end?

May not be: This may depend on what you are being treated with and for what. We sometimes see joint complaints from tapering perdnisone. That means as the dose drops joints can hurt. This is called steroid withdrawal rheumatism. You need to discuss this with your physician ...Read more

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How long does it take for prednisone to work for joint pain. I'm taking 10mg for 3 days then 20mg for the remainder of 2 weeks just started today?

How long does it take for prednisone to work for joint pain. I'm taking 10mg for 3 days then 20mg for the remainder of 2 weeks just started today?

Depends on cause: How quickly Prednisone works, if it works at all, depends on the cause of the joint pain. If you have an inflammatory arthritis like rheumatoid it may start helping within days. If you have severe bone on bone osteoarthritis it may not help at all that may only be helped with an injection into the joint. ...Read more

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How do I treat inflamed sternomanubrial joint? Prednisone is not working.

How do I treat inflamed sternomanubrial joint? Prednisone is not working.

DMSO: Try DMSO (dimethylsulfoxide). DMSO (aka horse liniment) is a powerful anti-inflammatory pain reliever. It's available in health food stores and feed stores (agriculture and veterinary supplies). It's usually available as a 99% liquid, and a lower strength gel and roll-on. The liquid works well, but may be drying or irritating to some people with sensitive skin. Just apply it daily. ...Read more

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What can I do to stop joint pain as a side effect from prednisone?

What can I do to stop joint pain as a side effect from prednisone?

Need to know what: We need to know what type of joint pain. To some this will be counter intuitive as prednisone can help some types of joint pain. We need to know what type of health problem you are are taking prednisone for. Is the pain you have joint, or muscle? What other medical issues do you have?
Your physicians will help you clarify these issues. ...Read more

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I've got stills im 23, my joints r swollen I've been on prednisone high doses for months, I've had cort. Shots in knees, n ntfs don't work, what will help?

I've got stills im 23, my joints r swollen I've been on prednisone high doses for months, I've had cort. Shots in knees, n ntfs don't work, what will help?

Other Rx: Even though tnfs did not help, there are other biologic agents which have shown good results. One drug is Kineret (anakinra) which works on il-1 (interleukin-1) instead of tumor necrosis factor (tnf). Be sure to let your rheumatologist know that you are still in pain and that you cannot taper off the steroids. ...Read more

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On top of bone deterioration, what other side effects from prolong use of prednisone?

On top of bone deterioration, what other side effects from prolong use of prednisone?

Long list: The big ones besides osteoporosis are diabetes, avasculr necrosis, weight gain, cataracts, glaucoma among others.

However; if you have a condition that warrants being on Prednisone where doctor feels that benefits outweight the risks you should consider taking the medication. Talk to your doctor. ...Read more

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I'm a 16y/o boy who is 5'1. I am scared about my height because of prednisone use at age 12-14. My bone age is 15. Will I grow any more?

I'm a 16y/o boy who is 5'1. I am scared about my height because of prednisone use at age 12-14. My bone age is 15. Will I grow any more?

Should grow more: Most with a bone maturity of 15 y have at least an inch or two more they will grow. I wouldn't expect six, but you should get some. Expected genetic height (without prednisone effect) would be the average of your parents plus 2.5 inches +/-. ...Read more

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Intermittent "bone pain" feeling in tibia for 3 days (at rest), unrelated to activity/injury. Could bone cyst explain it? Or prior prednisone use?

Sometimes: Prednisone can cause both bone and joint problems. If you have had long treatment courses of prednisone, it could weaken the bone and make you more susceptible to stress fractures though I would expect some pain with weight bearing. Bone cysts unlikely in your age group. As always, if pain persists, see your doctor. ...Read more

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I am only 125 lbs taking 20mg prednisone daily and only getting slight relief for severe joint pain morning stiffness. Normal? Making my BP high also

Unusual treatment: 26 yo female notes ineffectiveness of prednisone for widespread pain; apparently absent any specific diagnosis. This is inappropriate. An Osteopath or Rheumatologist should be consulted. Fibromyalgia might be a consideration, and a specific diagnosis is needed in order to initiate rational medical therapy. ...Read more

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If I am on 20mg prednisone daily for severe joint pain and morning stiffness should I feel 100% relief or will I still have pain? Feel slightly better

If I am on 20mg prednisone daily for severe joint pain and morning stiffness should I feel 100% relief or will I still have pain? Feel slightly better

Should help: Prednisone is a potent anti inflammatory agent. At that dose, it suggests you have inflammatory joint disease. While most pain should be improved with this dose, you may also benefit from NSAIDs as well. Discuss this with your prescribing doc. ...Read more

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I have ra. Weaned myself off prednisone. Having joint pain. What to do?

I have ra. Weaned myself off prednisone. Having joint pain. What to do?

See below: With ra, and in flare, you may need to be restarted on steroids again such as prednisone. Pain meds such as anti-inflammatory can help with pain in the meantime, however, you will need other meds that can acts like a maintenance medication, some are oral like methotrexate, some injectables like remicade (infliximab). A rheumatologist will need to see you for evaluation and further treatment. ...Read more

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I have been trying to taper off prednisone from a colitis flare up. It has been horrible and my joints have become so sore every time I hit the 10 mg?

I have been trying to taper off prednisone from a colitis flare up. It has been horrible and my joints have become so sore every time I hit the 10 mg?

Other meds?: If you have severe enough crohns disease that it requires prednisone, it is unlikely that you will be able to just taper off without the use of a steroid sparing agent such as biological agents (ie. Remicade) or immunomodulators (mercaptopurine). See your gastroenterologist or am did a referral
to an ibd subspecialist. ...Read more

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Neurosarcoidosis. Having bad joint pain for few days. First time with this symptom. On 20mg prednisone. Is it the sarcoid or the steroids? Ty

Neurosarcoidosis. Having bad joint pain for few days. First time with this symptom. On 20mg prednisone. Is it the sarcoid or the steroids? Ty

Impossible to say: It is impossible to say with knowing your complete history and doing a thorough evaluation. Ask the doctors who care for you or see a rheumatologist. ...Read more

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My wife, 33weeks pregnant. Diagnosed with itp. Given prednisone then now ivig. If still failed, then bone marrow. Is that a big risk? Now 36weeks

No: Itp can occur late in pregnancy. Performing a bone marrow on a pregnant patient in experienced hands is typically not a great risk. I do not use sedation, but topical numbing agent with numbing of the top of the bone and skin. Well done risks are pain, low risk of bleeding and low risk of infection. Many times, if patients fail prednisone, ivig we use rituxan (rituximab). Make sure itp diagnosis is correct. ...Read more

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Dad had pmr and was on prednisone, he weaned off but 7 months later he has severe joint pains w/ no inflamitory markers all over. Prednisone effect?

Dad had pmr and was on prednisone, he weaned off but 7 months later he has severe joint pains w/ no inflamitory markers all over. Prednisone effect?

Suspect PMR relapse: It's very common to have a relapse in Polymyalgia Rheumatica.Depending on the study the average time a patient with PMR requires prednisone is 3-6 years. Although very uncommon, patients with PMR can have a normal ESR.Was a CRP done? Because patients with PMR have a dramatic response to even small doses of prednisone (15-20 mg daily) most physicians would restart prednisone and expect quick response ...Read more

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I have had itchy hives for about 6 months and drs give me prednisone and it goes away. I get joint and muscle pains with too. What could it be?

I have had itchy hives for about 6 months and drs give me prednisone and it goes away. I get joint and muscle pains with too. What could it be?

Well: If you had taken Prednisone in moderate doses for several months, then the bone pain may well be from the cortisone effect (bone loss). However it the pain occurred at the same time as the hives, I would be more concerned with an autoimmune process and would advise you to consult a rheumatologist. ...Read more

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Is Florinef (fludrocortisone) 0.5 mg every other day bad for my bones? (I POTs syndrome & can't function without it.) Is it as bad as a steroid as low dose prednisone?

Is Florinef (fludrocortisone) 0.5 mg every other day bad for my bones? (I POTs syndrome & can't function without it.) Is it as bad as a steroid as low dose prednisone?

NO!: Florinef=fludrocortisone which is a mineralocorticoid and not a glucocorticoid. It is unique in that it is essentially a pure mineralocorticoid. Glucocorticoids have effects on bone and mineralocorticoids on salt and potassium regulation. They are related in structure & being made in the adrenal, but not function (although some steroids have both functions). A pure mineralo will not effect bone. ...Read more

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Does a six-month regimen of prednisone (for IGA nephropathy) risk damage to hips/joints? Husband is having hip pain after a month on the drug.

Prednisone effect: One of the major side effects of Prednisone is bone loss. The importance of it depends on the underlying bone health/condition of the individual. We generally acquire a bone density scan before starting long term steroid therapy and if we find signs of underlying osteoporosis we treat it at the same time (with Calcium, Vitamin D analogs, and Bisphosphonates). Your husband probably need one now! ...Read more

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Inflamm muscles and joints."flares" throught month since 05.Dr sees no active infection (virus etc) prednisone stops sx. What else wld u test for?

Inflamm muscles and joints."flares" throught month since 05.Dr sees no active infection (virus etc) prednisone stops sx. What else wld u test for?

Autoimmune diseases: Based on your description, you might have any one or more of autoimmune diseases such as systemic lupus erythematosus, polymyalgia rheumatica, etc. You might have fibromyalgia too. You might even have viral hepatitis (B or C) or inflammatory bowel disease such as Crohn's or ulcerative colitis. Get tested for ANA, CRP.... The best thing for you to do is to see a good board-certified rheumatologist. ...Read more

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I have a sore on my jawline and collar bone-deep and painful. In ICU visiting for two weeks. I am sick, zpak, prednisone not helping. Could it be mrsa?

Need culture: In order to know what is possibly growing in those sores a swab needs to be obtained and cultured. Not sure how these sores relate to you current illness. Follow-up with your prescribing physician for on-going evaluation and changing of treatment if necessary. ...Read more

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Is 700 cal per day good to loose weight? I can't do exercise due to joint pain have sle and on prednisone since 3 years.

Is 700 cal per day good to loose weight? I can't do exercise due to joint pain have sle and on prednisone since 3 years.

Starvation is bad: Starvation diets do not work. They change one's metabolism and they do not lead to any lasting weight loss. In fact they often lead to rebound weight gain.

I would not recommend any limitation of calories lower than 1200 to 1500 calories for a true diet. ...Read more

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Why is my SED, CRP normal even with pleurisy and swollen joints and prednisone is only thing that helps? SLE. Why does it not pick up on the inflamm?

Why is my SED, CRP normal even with pleurisy and swollen joints and prednisone is only thing that helps? SLE. Why does it not pick up on the inflamm?

No easy answer: Please forgive me. Sed rate and C-reactive protein are famously unreliable markers for inflammation in lupus and suspected lupus. A different pathway of inflammation is often involved. Despite "pop" ideas about "inflammation", inflammation enormously complicated. If it weren't, common painkillers would clear depression, which some folks describe as "a form of inflammation." ...Read more

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Active 26 yo with debilitating muscle/bone pain 9 mnth my clothes feel like weights 20mg prednisone 1000mg naproxen no help ANA1:320 RF DNA neg?

Active 26 yo with debilitating muscle/bone pain 9 mnth my clothes feel like weights 20mg prednisone 1000mg naproxen no help ANA1:320 RF DNA neg?

Diagnosis?: It sounds like you've had part if a work up for autoimmune disease with a somewhat significant elevation of ANA titer, and you have joint pains. It's important to do joint and long bones films as well as more specific immune testing to get you better pain relief and specific autoimmune treatment. Find a reliable Rheumatologist and get started... ...Read more

Bone (Definition)

Bone is a living growing tissue made mostly of collagen (protein that provides soft framework) & the mineral calcium phosphate that adds strength & hardens the framework. Two types of bone are found in the body; cortical (dense compact outer layer) & trabecular (makes up inner layer, ...Read more


Dr. Stratos Christianakis
1,189 Doctors shared insights

Joints (Definition)

Joints are parts of the body, formed by the cartilage-covered ends of bones plus the strong, flexible ligaments that attach the bones to one another. Movements at the joints in the body allow the different parts of the body to move in ...Read more