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Doctor insights on: Prednisone And Benadryl Medication

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I have red patches all over my body they itch. I went to the hospital and the gave me benadryl, (diphenhydramine) prednisone, &cimetidine these medications did nothing!?

I have red patches all over my body they itch. I went to the hospital and the gave me benadryl, (diphenhydramine) prednisone, &cimetidine these medications did nothing!?

Foolish: ER people treat heart attacks, accidents, emergencies. That's why we call it the emergency room. They are poor at treating "red patches all over". What did they call it? Stop this foolishness and see a dermatologist. When you call, indicate if it is urgent. Is your water safe yet? Do not take Benadryl (diphenhydramine) except bedtime. It is a sleeping pill. Cimetidine is for acid stomach, not for skin. You need a p ...Read more

Dr. Thomas Namey
2,568 Doctors shared insights

Prednisone (Definition)

Prednisone is a synthetic cortisone. The body makes cortisone, a natural hormone made in adrenal glands. The body converts it to Hydrocortisone to become active. 25 mg of cortisone has about same effect as 5 mgm prednisone. The average person would produce 3-6 mg of pred daily. So why use a substitute? The synthetic has more anti-inflammatory effect; but has less effect ...Read more


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I took prednisone 50mgX3 and Benadryl (diphenhydramine) 50 mg as pre med for contrast study, I need additional test how long should I wait between appointments?

I took prednisone 50mgX3 and Benadryl (diphenhydramine) 50 mg as pre med for contrast study, I need additional test how long should I wait between appointments?

Contact the Doctor: Contact the Doctor ordering the test to set up a plan of action that you can follow. You may need to take additional medications depending on the type of contrast and or test. ...Read more

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I know prednisone lowers your immune system, so can I take Benadryl (diphenhydramine) instead?

I know prednisone lowers your immune system, so can I take Benadryl (diphenhydramine) instead?

Yes, in occasions: You've got an excellent point. For example, in treating sinusitis caused by allergic nasal congestion, Benadryl (diphenhydramine) treatment has much less side effects than prednesone. ...Read more

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Can I take prednisone, Zantac and Benadryl (diphenhydramine) for allergies?

Can I take prednisone, Zantac and Benadryl (diphenhydramine) for allergies?

Yes, but: It is bit much, especially the prednisone. And the Benadryl (diphenhydramine) makes most people sleepy. I would recommend a non-sedating antihistamine, such as loratadine, cetirizine, or fexofenadine. ...Read more

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Hi! I have been having hives for the past three days and I have taken benadryl, (diphenhydramine) prednisone, and ranitidine when will they go away?

Hi! I have been having hives for the past three days and I have taken benadryl, (diphenhydramine) prednisone, and ranitidine when will they go away?

Depends on cause: How long it lasts depends on what is causing it. Having said that, they are often caused by a viral infection. In this case, they should go away after a few weeks. On the other hand, it may also linger on for years ...Read more

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7wks pregnant, Is prednisone safe for treating my 1st time hives 3 days going, Benadryl (diphenhydramine) seems to calm it, appears after 8 hrs effect, is this safe?

7wks pregnant, Is prednisone safe for treating my 1st time hives 3 days going, Benadryl (diphenhydramine) seems to calm it, appears after 8 hrs effect, is this safe?

Not really safe: Studies suggest that there's a small increased risk of oral clefts when taking Prednisone in the first trimester. An oral cleft happens when the lip or palate (roof of the mouth) does not fully close during development. Before you take prednisone, discuss other options with your healthcare provider. There are other medicines available that may be safer and still keep your hives under control. ...Read more

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"i have a rash and it will not stop itching I went to the e.r last night and they prescribed me prednisone and told me to take Benadryl (diphenhydramine) I am 20 weeks?

"i have a rash and it will not stop itching I went to the e.r last night and they prescribed me prednisone and told me to take Benadryl (diphenhydramine) I am 20 weeks?

See derm: Pregnancy alone can be associated with skin rash sometimes severe. A short-course of prednisone is the usual treatment. Benadryl (diphenhydramine) does help by making you a little drowsy and probably not from its antihistamine effect. If the problem continues, consult a dermatologist. ...Read more

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I'm currently taking 275 of Benadryl (diphenhydramine) all day and singular, pepsid and Zyrtec along with prednisone. Have suffered with anaphylactic shock. Zofran ok?

I'm currently taking 275 of Benadryl (diphenhydramine) all day and singular, pepsid and Zyrtec along with prednisone. Have suffered with anaphylactic shock. Zofran ok?

Zofran (ondansetron): Is just another antihistamine, acts centrally though, and mainly for nausea/vomiting, won't add any benefit if you already are controlled on the medicines mentioned, besides it isn't the first line therapy in anaphylaxis. Discuss with your doctor if you still have symptoms, good luck ...Read more

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What is the correct dosage for children's Benadryl (diphenhydramine) allergy for 19 month toddler 21.5 lbs? Is it ok to use Benadryl (diphenhydramine) with alubeterol/prednisone inhalant

What is the correct dosage for children's Benadryl (diphenhydramine) allergy for 19 month toddler 21.5 lbs? Is it ok to use Benadryl (diphenhydramine) with alubeterol/prednisone inhalant

1 teaspoon or 5cc's: Benadryl (diphenhydramine) can be used with the Albuterol and Prednisone. The dosage of Benadryl (diphenhydramine) for your child's weight would be about 1 teaspoon (5cc) being that the concentration of the Benadryl (diphenhydramine) is 12.5mg per each teaspoon. Remember, if your child is having breathing problems, always consult with your Pediatrician. Take care. ...Read more

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Had allergic reaction to Minocycline. Hives, heartburn, chills, feeling ill. Took prednisone/benadryl. Hives gone for 4 days, why am I still itchy?

Had allergic reaction to Minocycline. Hives, heartburn, chills, feeling ill. Took prednisone/benadryl. Hives gone for 4 days, why am I still itchy?

Inflammation: ! st drug such as minocycline tends to linger on in the tissue longer. 2nd the inflammation triggered by the drug takes 1-2 weeks to resolve even after the drug has been discontinued. Think of it as a deep scratch on your skin, it won't heal immediately just because you have stopped scratching it. ...Read more

Dr. Al Hegab Dr. Hegab
3 doctors agreed:
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6 hrs ago had Allergic reaction to bee sting, emt gave Benadryl, (diphenhydramine) then doctors at hospital gave prednisone and pepcid, Can next dose benadryl (diphenhydramine) b taken?

Dr. Al Hegab Dr. Hegab
3 doctors agreed:
6 hrs ago had Allergic reaction to bee sting, emt gave Benadryl, (diphenhydramine) then doctors at hospital gave prednisone and pepcid, Can next dose benadryl (diphenhydramine) b taken?

Yes: If you feel you still need it, but don't exceed recommended daily dose for diphenhydramine from all sources (300 mg /day), depends on the reaction too was it a local or whole body reaction? Keep taking the benadryl for the next 24 -48 hours every 4-6 hours as needed 25- 50 mg, don't drive, and take the medicines prescribed at ER, if it was a whole body reaction, see an allergist, take care ...Read more

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Diphenhydramine, prednisone, ranitidine are given to my dad before he does his cardiac cath. Is those going to help him not be allergic to iodine?

Diphenhydramine, prednisone, ranitidine are given to my dad before he does his cardiac cath. Is those going to help him not be allergic to iodine?

Allergy: Iodine is not the problem. Has he ever ingested "iodized" salt? If so, he is not iodine allergic. The IV contrast used in the cath is a spontaneous mast cell degranulator that causes the allergic reaction. We suppress this with those three meds prior to IV contrast to prevent reactions. ...Read more

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I've been taking prednisone and benedryl for a beesting for 3 days now and the swelling is getting worse what can I do Last time I was n hosp. 4 2week?

I've been taking prednisone and benedryl for a beesting for 3 days now and the swelling is getting worse what can I do Last time I was n hosp. 4 2week?

Please revisit: Your doctor, you might need a larger dose, and keep epinephrine pen handy, also please get referred to an allergist asap, for evaluation and possible desensitization, 2nd time bad reaction is no joke, check aaaai. Org or acaai. Org for an allergist in your area, good luck ...Read more

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I have a insect bite intolerance. Yesterday I had another bite, I'm taking prednison 30 mg p/day (5 days) and Benadryl (diphenhydramine) 50 mg. Cooling makes it worse.

I have a insect bite intolerance. Yesterday I had another bite, I'm taking prednison 30 mg p/day (5 days) and Benadryl (diphenhydramine) 50 mg. Cooling makes it worse.

Topical sprays..: Any shortness of breath? go to the ER. Otherwise, try a topical spray - like the kind used for sunburn which contain lidocaine. Might bring some relief. Watch for redness & swelling, which could be signs of developing infection. Best wishes ...Read more

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I have been getting hives for the past 3 days now and they seem to get worse each time. I'm taking prednisone & 2 antihistamines. What else can I do?

I have been getting hives for the past 3 days now and they seem to get worse each time. I'm taking prednisone & 2 antihistamines. What else can I do?

No scratching: Think about everything you've eaten or been exposed to in the last 3 days or viral symptoms. Sometimes they are idiopathic. Ask your doctor to check your blood counts, ANA, thyroid function if they persist and become chronic. Some dermatologists advise zantac (ranitidine) as an H1 blocker which can enhance histamine blockade of antihistamines. Singular is another idea. Aveeno oatmeal baths, cut fingernails. ...Read more

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What are the risks of low-dose oral prednisone taken over 1 or 2 decades? I am a vet with allergies to pets. Antihistamines not effective anymore.

What are the risks of low-dose oral prednisone taken over 1 or 2 decades? I am a vet with allergies to pets. Antihistamines not effective anymore.

It depends how low: If the dose is low it will replace what your adrenal makes. Even at that level it is tough sometimes to get off of it. With high doses bad problems can occur in all areas of your body. Talk to your doctor or get another opinion about what is best. Thank you for your service. ...Read more

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I am having an allergic reaction to cutting mdf fiberboard. The skin rash is terrible. How much prednisone can I take and can I take benadryll.

I am having an allergic reaction to cutting mdf fiberboard. The skin rash is terrible. How much prednisone can I take and can I take benadryll.

See your doctor: I would recommend that you see your doctor to make sure this is a contact dermatitis. You would not want to take Prednisone and unless you know what you are taking it for. The dose can vary based on she, weight, & diagnosis. Benadryl (diphenhydramine) is very short acting and may help itching only. ...Read more

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Hives urticaria x 3 weeks. Antihistamines and prednisone are moderately effective only with consistent use. Would a skin biopsy help determine cause?

Hives urticaria x 3 weeks. Antihistamines and prednisone are moderately effective only with consistent use. Would a skin biopsy help determine cause?

No: A skin biopsy can help prove that these are hives, but usually cannot help to identify a trigger (unless you have underlying blood vessel disease called vasculitis). Prednisone should be avoided if possible because the hives can come back stronger when it is stopped. There are many potential triggers to discuss with a physician and many effective treatment options. Recommend Health Tap consult. ...Read more

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Have pneumonia asthma bronchitis on prednisone 40mgx5 levoflaxcin500x7 is ok to take benedryl, cough supp and expectorant to manage severe coughing?

Have pneumonia asthma bronchitis on prednisone 40mgx5 levoflaxcin500x7 is ok to take benedryl, cough supp and expectorant to manage severe coughing?

Probably OK but..: If your cough is caused by uncontrolled asthma, then you need to get the asthma under control instead of relying on cough medicine to relieve the symptoms. On the other hand, if your lung function is reasonably good and the cough is too bothersome, I see no harm in taking a cough suppressant for a few days. I would suggest that you talk to your doctor about these issues. ...Read more

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I had an allergy to doxycycline 4 weeks ago I can't take benedryl and I took prednisone for 12 days and I still itch, I have been taking ranitidine?

I had an allergy to doxycycline 4 weeks ago I can't take benedryl and I took prednisone for 12 days and I still itch, I have been taking ranitidine?

Cause?: I doubt that the allergy to doxycycline can linger on this long and thus your itching must be from something else. In the absence of skin rash, dry skin is the most common cause for itching. Have you tried applying a moisturizer on your body 2x daily with one <3 mins after bathing? ...Read more

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I was given a coctail of toritol benedryl and something else for severe migraine in er along with 3 prednisone. I was prescribed roboxin 500mg 3x a day 2 pills at a time. After I urinate my lips feel numb or tingly. What is going on??

I was given a coctail of toritol benedryl and something else for severe migraine in er along with 3 prednisone. I was prescribed roboxin 500mg 3x a day 2 pills at a time. After I urinate my lips feel numb or tingly. What is going on??

Too many drugs: With so many new drugs it is hard to tell which or which combination may or may not be causing your symptoms. I can't link the urination to the lip sensation either. It is best that you consult a neurologist specialized in migraine. Have you tried triptan type of drugs yet for migraine? ...Read more

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Severe sulfa allergic reaction. Taking benedryl and prednisone. Not getting any better. Broke out in blisters all over body, red skin with pain stings?

Severe sulfa allergic reaction. Taking benedryl and prednisone. Not getting any better. Broke out in blisters all over body, red skin with pain stings?

Go to the er: There can be a very severe reaction that is a skin emergency. The most significant variant is called toxic epidermal necrolysis (ten). Another slightly less severe condition but on the same continuum is stevens-johnson syndrome. It is important with your current symptoms you get evaluated asap. The most common cause of both of these is drug reactions. ...Read more

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I've had reoccurring hives since Wed. They come&go. Went to urgent care& had to go to ER, on prednisone, zantac, benedryl&steroid cream, still no relie?

I've had reoccurring hives since Wed. They come&go. Went to urgent care& had to go to ER, on prednisone, zantac, benedryl&steroid cream, still no relie?

Keep taking ur meds: And try to see a dermatologist or an allergist for fine tuning your management. Most of the time there is no known cause for the acute hives, unless you can spot a clear reason, a food or a medicine or new exposure. Best wishes ...Read more

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Had hives for 7 weeks, got a steroid shot and 12 day prescription for prednisone that didn't fix and antihistamines do not work. Now have chills/night sweats.?

Had hives for 7 weeks, got a steroid shot and 12 day prescription for prednisone that didn't fix and antihistamines do not work. Now have chills/night sweats.?

Cause?: Did they ever find a cause for your hives? Be sure you are not on a new medicine or food that could be triggering them. Sometimes, you need a bigger dose of Prednisone tapered over a longer time to suppress the reaction. See your doctor again and ask about this. The chills may be due to coming off the steroid too quickly. If you don't improve on another round of steroid, see an allergist. ...Read more

Dr. John Chiu
1,049 Doctors shared insights

Diphenhydramine (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more


Benadryl (Definition)

Diphenhydramine is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more