Doctor insights on:
Postmenopausal Women And Osteoporosis
No: There have been many studies that have compared tamoxifen to placebo, demonstrating it's effectiveness treating breast cancer; none of these studies, to my knowledge, ever showed any difference between tamoxifen and placebo regarding weight gain. Nevertheless, as many as 10% of women on tamoxifen do report weight gain. This may be due to post-chemotherapy effects or menopause, as well. ...Read moreSee 1 more doctor answer
Yes: Estrogen deprivation (you've had your ovaries removed or they don't work) or exposure to certain medicines (eg, anti-psychotics, seizure medicines, steroids) can cause osteoporosis in women in their 30's. However, if you haven't been estrogen deprived or exposed to toxic medicines it's unlikely. Most women lose maximal bone mass within 3 years of after menopause. An xray test can determine risk. ...Read more
Is combined tamoxifen plus hormonal therapy better for breast cancer in pre or postmenopausal women?
Estrogen supression: In general, aromatase inhibitor is only indicated for postmenopausal women ;not for premenopausal; while on the other hand, tamoxifen can be given either in pre or postmenopausal. Only thing is that tamoxifen can cause a little bit higher risk for complication -i.e. Risk for blood clots and risk for develping uterine cancer- when used in older population- age of -65 Y.O. Or above. ...Read moreSee 2 more doctor answers
Varies: Estrogen levels vary between women and they vary all the time within the same women. There is a generally accepted range based on the time of the menstrual cycle. Women 12 year old woman have higher peak estrogen levels than 40 year old woman and vice versa. So that is a difficult question to answer and may not be as important as why levels change. ...Read more
Can POCS causes both high androgen and estrogen levels if not overweight? Can eating pyhytoestrogens increase breast cancer in women with POCS?
PCOS: PCOS can increase androgens in patients regardless of their weight. The effects on Estrogen are less clear as these levels fluctuate and typically would not be tested in PCOS. The LH and FSH levels are checked but not Estrogen. The effects of Phytoestrogens such as soy on the risk of breast cancer are debatable. There is not specific recommendation for PCOS patients to avoid them ...Read more
Age, estrogen: Cancer, in general, is more common in older people. Also, a strong risk factor for endometrial cancer is prolonged exposure to estrogen because of early menstruation, late menopause, childlessness, and use of estrogen therapy without progesterone. Obesity is a risk factor too because fat tissue is a source of estrogen. ...Read moreSee 2 more doctor answers
Great Question!: ...Unfortunately, not so great answer. We know that breast cancer incidence increases with age but we don't know why. We believe that cancer occurs when a cell is unable to correct a defect in its dna--perhaps this ability is diminished as we age, or the long-term effects of the "toxins" that contribute to breast cancer development are cumulative in nature. ...Read more
Is combined tamoxifen plus hormonal therapy more effective in pre or postmenopausal women and why?
Tamoxifen: We don't give tamoxifen in combination with hormone replacement in the us. Occassionally use vaginal very low dose estrogen cream for vag dryness and tell pts to use a little as they can to relieve symptoms. Blocking hormones and giving them at same time does not make much sense. ...Read more
70 yo female w/osteoporosis and family hx of BRCA breast cancer. Ok to Denosumab and Reloxifene therapy together??
Yes it is OK: You can take these medicines together. There is no significant interaction or harm. So relax and take them as advised by your doctor. ...Read more
Perimenopause: is the months before the cessation of menses. Many women have adequate estrogen during these months. Most women do not ovulate or ovulate sporadically during this transition so they do not produce progesterone. A blood test can determine your need. ...Read moreSee 1 more doctor answer
Controversial: Researchers in a large study found that "... Increasing calcium intake from diet might not confer significant cardiovascular benefits, while calcium supplements, which might raise [heart attack] risk, should be taken with caution." the increased risk may be due to high levels of calcium from 1-2 doses of supplement as opposed to the small amounts absorbed from diet. Ask your cardiologist on this. ...Read more
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