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Doctor insights on: Positive Lyme Titer Negative Western Blot

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what is difference between IgM and IgG for western blot for lyme. positive for IgM but not IgG, what does that mean? tks

what is difference between IgM and IgG for western blot for lyme. positive for IgM but not IgG, what does that mean? tks

Recent infection: Hi. IgM is present only with recent infection. After IgM levels fall away, IgG takes over for ongoing and recurrent exposure to antigen. (The antibodies in this picture are IgG's). I'm glad your doc was on the ball. She/he may have saved you a world of hurt by making the diagnosis promptly. Good luck! ...Read more

Dr. Randy Baker
623 doctors shared insights

Lyme Disease (Definition)

Lyme is caused by borrelia burgdorferi. Acute symptoms can include bullseye rash, headaches, joint pain, fever, and flu like sx. Chronic symptoms can include fibromyalgia symptoms, nerve pain in extremities, mood swings, brain fog, heart problems. Lab diagnosis is not very reliable, and sometimes clinical ...Read more


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What would cause a positive Lyme titer but negative western blot?

What would cause a positive Lyme titer but negative western blot?

see details: The lyme titer is nonspecific and can be positive by itself if the presence of other autoimmune diseases, viral infections or a history of lyme in the distant past. I negative western blot rules out active lyme disease. ...Read more

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Lyme antibody positive and western blot negative. Where can I find a complete list of other id's associated with a positive igm/igm antibody screen?!

Lyme antibody positive and western blot negative. Where can I find a complete list of other id's associated with a positive igm/igm antibody screen?!

Probably have Lyme!: I don't know where to find such a list as I am not sure the causes of a false positive are known, but, esp. If the western blot did not include the 34 ; 39 bands i would not rely upon it; please do the igenex western blot, which is much more sensitive ; specific for lyme. Even if that is negative 20-30% with lyme can have a negative WB test. Other tests may be indicated. See http://bit.Ly/1aaqjgc. ...Read more

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Can you have Lyme disease and still have a negative test result on the western blot test?

Can you have Lyme disease and still have a negative test result on the western blot test?

Possible: Lab tests have false negatives and false positives. Each lab test result needs to be interpreted in the clinical context. A person may have infection with lyme disease and may not make appropriate antibody and have a negative test while the test is working properly. ...Read more

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Can a positive Lyme disease western blot strip test be mistaken for another disease?

Can a positive Lyme disease western blot strip test be mistaken for another disease?

Yes!: No lab test is perfect, including the westen blot for lyme. There is an approximately 4% chance of a positive being a "false positive" test. There is also an approximately 20% chance of false negatives, someone with lyme not having a positive western blot. This is why lyme is ultimately a clinical diagnosis, with labs used to support a diagnosis. Other tests may also be useful. Please see comment:. ...Read more

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How can someone test positive for two Lyme-specific bands on western blot and NOT have been exposed to Lyme disease? What is magic about 5 bands?

How can someone test positive for two Lyme-specific bands on western blot and NOT have been exposed to Lyme disease?  What is magic about 5 bands?

Immune complexities: Lyme disease is caused by a certain type of bacteria called a 'spirochete'- they are a whole class actually of bacteria and believe it or not can be found commonly in the mouth or elsewhere in the environment. You have to reach a certain 'threshold' with Lyme testing because there could be some cross-reactivity coming from these other types of bacteria. The immune system is extraordinarily complex ...Read more

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Tested positive for Lyme disease IgM but my western blot test came back negtive?

Then it's not Lyme: Lyme disease can be tricky -and you want to make sure you see someone like an Infectious Diseases doctor who knows how to treat it. The diagnosis is actually based on clinical findings, and the lab testing is generally 'supportive'. Since you're Western blot is negative, then it's very unlikely you have Lyme. There are other diseases that could cause 'Lyme-like' symptoms -and good to get evaluated ...Read more

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With lyme disease you have ELISA and western blot but what if you tested ELISA negative is Lyme disease impossible? Or wise to do western blot?

With lyme disease you have ELISA and western blot but what if you tested ELISA negative is Lyme disease impossible? Or wise to do western blot?

Lyme blood test: In early Lyme Disease Elisa can be negative. No use testing Western Blot if Elisa is negative. Follow patient clinically and if symptoms of Lyme disease occur re-test Elisa. ...Read more