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Doctor insights on: Positive Hla B27 Antigen

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Hello, could I still have rheumathoid or other type of arthritis if ana, anticcp, crp, esr, rheumathoid factor, hla-b27 antigen are all in range?

Hello, could I still have rheumathoid or other type of arthritis if ana, anticcp, crp, esr, rheumathoid factor, hla-b27 antigen are all in range?

Sounds like: You had a fairly complete serologic work-up. With this information one would expect garden variety osteoarthritis as the cause of your joint issues -- more degenerative than inflammatory. ...Read more

Dr. Daniel Saurborn
59 Doctors shared insights

Hla B27 (Definition)

Hla = human leukocyte antigen. Important in recognition of self and not self. Different proteins (antigens) for different people. B is one of the loci, and hlab27 has been associated with predisposition to immunologic rheumatologic ...Read more


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Faitgue w/knee and hip pain, a +ccp antibody, a - hla-b27 antigen? Possible ra?

Faitgue w/knee and hip pain, a +ccp antibody, a - hla-b27 antigen? Possible ra?

Maybe: Ra is possible although the pattern of involvement is not that typical. How positive was the ccp? Unless it is strongly positive it is not that specific for ra. ...Read more

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Fatigue, hip&knee pain with+ccp antibody and -hla-b27 antigen, could it be possible ra?

Fatigue, hip&knee pain with+ccp antibody and -hla-b27 antigen, could it be possible ra?

Probable: Ra is a clinical diagnosis confirmed by lab results and not the other way around. Hla-b27 is not a feature of RA although ccp ab is. ...Read more

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Negative hla-b27 antigen. Normal cpk, esr. Crp 1.6. Ra neg. For 7 months stiff sore muscles in hips, shoulders back what could this be? Doctor not sure.

Negative hla-b27 antigen. Normal cpk, esr. Crp 1.6. Ra neg. For 7 months stiff sore muscles in hips, shoulders back what could this be? Doctor not sure.

Age, side effects,,,: This could be from just age effects on your muscles, especially if you've used them a lot during your lifetime for housework or in your work. You're on two medications for muscle relaxation that could have side effects invoking your nervous system and ultimately your muscles, and they might ache afterwards. You therefore might think of seeing your doctor to get off the meds (except nsaids). ...Read more

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Is testing positive for HLA-B27 a good thing?

Is testing positive for HLA-B27 a good thing?

Maybe: You're more at risk for reactive arthritis and ankylosing spondylitis, and finding you have HLA-B27 may help clinch the diagnosis if it seems likely already. Why were you tested? The vast majority of folks who are positive never have any problems with it whatsoever. ...Read more

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Positive for hla-b27.This procedure rules out the b27:06 & 27:09 alleles which lit suggests aren't associated w/ spondyloarthropathies. What this mean?

Positive for hla-b27.This procedure rules out the b27:06 & 27:09 alleles which lit suggests aren't associated w/ spondyloarthropathies. What this mean?

Spondyloarthritis: Hlab27 is a generic marker that is in 8% of the caucasian population. Many people with diseased called spondyloarthropathies (ankylosing spondylitis, psoriatic arthritis, and crohns/uc related arthritis) will have a positive b27, but not all those with b27 will develop issues (in fact, the vast majority don't). The larger question is are the symptoms consistent with spondyloarthropathy. ...Read more

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If RF, anti CCP, HLA B27 is negative and ANA is positive what diseases can be suspected?

If RF, anti CCP, HLA B27 is negative and ANA is positive what diseases can be suspected?

Long list: Any autoimmune disease possible, its just a basic screen test, more depands on history and syymptoms. ...Read more

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What does it mean if I'm hla-b27 positive? I have severe hip pain- does it have to do with this?

What does it mean if I'm hla-b27 positive? I have severe hip pain- does it have to do with this?

Susceptibility to: Some disorders. People who have the hla b-27 antigen are more prone to some diseases, e.G, ankylosing spondylitis. It does not mean the person has it, just that person is more likely to have some inflammatory disorders, including inflammation of joints. ...Read more

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I am hla-b27 positive. I've suddenly had 6 iritis flareups in the last 2 years. I think they are caused by contact lens abuse. Thoughts please.

I am hla-b27 positive. I've suddenly had 6 iritis flareups in the last 2 years. I think they are caused by contact lens abuse. Thoughts please.

Aggravated: The "cause" is you auto immune disease
it may be aggravated by the contacts, (foreign body, decrease oxygen, etc)
but this many flare ups means you need better control of your auto immune disease. ...Read more

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Had 2 blood tests for hla b27. 1st test came back positive; 2nd test (pcr) came back negative. What would be the difference between the two tests?

Had 2 blood tests for hla b27. 1st test came back positive; 2nd test (pcr) came back negative. What would be the difference between the two tests?

HLA B27 Asssay: The pcr method has better sensitivity and specificity than the 1st test, antigen assay. Your symptoms and other clinical findings are more important. ...Read more

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If blood test by PCR was negative for hla b27, does this mean I definitely don't have it? (one other blood test was positive; not sure of the type).

If blood test by PCR was negative for hla b27, does this mean I definitely don't have it? (one other blood test was positive; not sure of the type).

HLA B27: Indicates a genetic predisposition associated with ankylosing spondylitis and a number of inflammatory disorders. It does not mean you don't have whichever disorder you are referring to. ...Read more

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2 blood tests done for hla b27: one was pos. And one was neg. (pcr). What is the difference of tests & what would trigger a positive with first test?

HLAB27: So, one test by pcr, the other test is what?
If the two tests were different, do the test that is known to be more sensitive and get two readings of it. ...Read more

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Ayurvedic treatment effective for hla b27 positive?

Ayurvedic treatment effective for hla b27 positive?

B27 not a disease: Hla b 27 by itself is not a disease, therefore the question of effectiveness of a treatment is moot. B 27 is associated with a particular form of arthritis. ...Read more

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I am suffering with severe pain in my hips for last 5 yrs, have hla b27 positive. Mri was okay. Please advice?

I am suffering with severe pain in my hips for last 5 yrs, have hla b27 positive. Mri was okay. Please advice?

AS: Ankylosing spondylitis is of concern. A plain x-ray of the sacroiliac joints would pick up images of bone sclerosis better than an mri. A rheumatologist can discern and advise. Traumatic injury to the sacroiliac joints is a consideration. Has there been participation in extreme sports? An osteopath can evaluate injury to the sacroiliac joints. ...Read more

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What do you advise if I'm suffering with severe pain in my hip araes for last 5yrs, have hla b27 positive. MRI ws ok. Pl advice?

See details: Have you seen a rheumatologist to be sure you do not have spondylitis. Many people believe they have hip pain when in truth it comes from the lower back. There are very effective therapies for B27 associated diseases. ...Read more

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My doctor said me that I am suffering from seronegative spondyloarthropathy. My crp is high 27. My hla-b27 report is also positive.

My doctor said me that I am suffering from seronegative spondyloarthropathy. My crp is high 27. My hla-b27 report is also positive.

The question?: I don't understand what you would like us to do with the statement. It appears that you do have an inflammatory type of arthritis however. Best to consult a rheumatologist. ...Read more

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If both parents are HLA-B27+ would that guarantee all offspring to have the gene? If so would only 1 positive parent make it a 50% chance?

If both parents are HLA-B27+ would that guarantee all offspring to have the gene? If so would only 1 positive parent make it a 50% chance?

No: Mendel's laws. Each parent has one copy of this and one copy of another. Let us assume neither parent has two copies. There is a 75% chance. Now, why do you ask? HLA-B27 is common, and the only thing that makes it troublesome is that it gives a few percent of folks joint problems. It is not a reason to forego parenthood. Ask whether your sacroileitis might benefit from today's new Rx's. ...Read more

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If positive for the hla b27 gene and 2cases of iritis, does this mean I have ankylosing spondylitis for sure? R these 2 factors enough for a diagnosis?

No: Hla b27 increases the risk for uveitis. Ankylosing spondylitis is associated with this but the diagnosis is made by physical exam and positive spine and hip x-rays. I have lots of patients with uveitis and hla b27 without other disease. ...Read more

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I had a positive HLA B27, positive ANA, positive SM anitobody, and a positive RNP. And Raynauds, is this likely Lupus?

I had a positive HLA B27, positive ANA, positive SM anitobody, and a positive RNP. And Raynauds, is this likely Lupus?

Lupus is a clinical: Diagnosis, made based on the presence of physical symptoms and specific organ involvement and is not a diagnosis made by the presence of a genotype or auto antibody. What symptoms have you had that prompted your physician to do this series of tests? What is the opinion of the rheumatologist seeing you (or are you still awaiting a visit with rheum?) These disorders are complex/overlap. Talk w/ URMD ...Read more

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Hi. I just want you to ask about stem cell therapy. Actually before hla b27 was positive now doctor said me to do hip replacement so what I do?

Hi. I just want you to ask about stem cell therapy. Actually before hla b27 was positive now doctor said me to do hip replacement so what I do?

Don't quite undersz: -stand the question. Pretty young for ankylosisng spondyosis 2 appear. Also there R about 10% or so false positives. No stem cell activity in degerative hip disease. R U sure of AS? Personally I suspect it the HLA-B27 is false& any hip disease is unrelated. Get in 2 C an internist who specializes in AS. Also get a second opinion. ...Read more

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What autoimmune diseases may cause raised ALT, ankle pain, chest pain, spine & shoulder pain without ANA, HLA B27 being positive?

What autoimmune diseases may cause raised ALT, ankle pain, chest pain, spine & shoulder pain without ANA, HLA B27 being positive?

Not many: Sounds like you have already had a "work-up" for your symptoms (ANA. HLA B27 are not :common" tests
The raised ALT may or may not be associated with your other symptoms. Do you have a liver problem? Hepatitis B, C often cause associated joint problems.
Get this checked out by the same Health Care Provider who obtained the blood tests you mention
Hope this helps

Dr Z ...Read more

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What type of doctor can order a hla b27?

Rheumatologist: On an internist or family doctor can order it if indicated. ...Read more

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Why would my doctor be testing my hla-b27 gene?

Why would my doctor be testing my hla-b27 gene?

Arthritis disease: The hla b-27 is a genetic test for ankylosing spondylitis and a group of similar diseases called seronegative spondyloarthropathies. ...Read more

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Is hla b27 testing a very common procedure?

Is hla b27 testing a very common procedure?

Yes: There are several labs which run this test. It looks for a protein on the surface of your white blood cells. ...Read more

Antigen (Definition)

Antigens are chemicals which upon exposure to the surface or inside of the body, will cause a reaction term allergic. Many substances will do this and allergic response is the basis for immunological protection for ...Read more