Doctor insights on:
Positive Brca Gene
From a medical standpoint, "genetic" refers to the potential heritability of various medical conditions. While some conditions are inevitable (at some point in one's life) as a consequence of simple genetic heritability (eg huntington's disease), a large number of medical conditions (including all behaviorial health disorders) are the expressed final pathway of a ...Read more
We're Getting There: In the past, we used anatomic staging alone (tumor size, lymph node involvement) to guide rx. Gene profiling allows us a completely separate measure of prognosis, and, more importantly, can predict who may or may not benefit from different chemotherapy agents. In the future, we will hopefully be able to tailor our rx to the specific cancer being treated: the elusive personalized medicine. ...Read more
Clarifying Q & A: In the general population, the incidence of a brca1 mutation is between 1:500 to 1:800. It is much lower for brca2. For a woman or offspring to inherit the gene from a parent who has one copy of the mutated gene, there is a 50% chance of acquiring the gene in question. It is autosomal dominant and therefore can manifest its deleterious consequences by itself without need of a second copy. ...Read more
Tumor: Monoclonal proliferation of lymphoid cells is usually an indication of tumor of the lymphoid tissue. ...Read more
Likely not much: The existing evidence does not support any strong connection between heterozygotes for either the c or a mutations of mthfr and poor pregnancy outcomes. Homozygotes may well be at greater risk. Depending on clinical history, different levels or surveillance and possible intervention can be considered. ...Read moreSee 2 more doctor answers
Good question. : The answer is no, a small number of patients with early onset breast cancer who carry a bad brca 1 or 2 mutation develop it "de novo", meaning that it started with them (after all, someone has to be the first to have it). Depending at which stage in development it happens, it may affect them to a different degree and may or may not be passed to their children. Some other cancer syndromes.. ...Read moreSee 1 more doctor answer
My 34yr sister had brca1and2 testing.Her brca 2 sequencing back positive as "likely pathogenic".What does that mean?Negative for brca 1 sequenc/depdup
Hiv RNA qualitative test negative; but absolute CD4 helper-879;% CD4 pos. Lymph-31.4;abs.Cd8 suppressor-1204;% cd8 pos lymph-43.0;cd4:cd8 ratio-0.73?
I wouldn't worry: Cd4 normally runs around 500-1000. Cd8 usually runs 150-1000 or so, but these ranges are set so that several percent of healthies fall outside. I'm not worried; you can repeat the RNA if you mistrust the lab. In healthy folks, the values vary chaotically. I had burning mouth for weeks after coxsackie herpangina and a viral infection may have through your cells out of kilter briefly. ...Read more
1.Toxo IgM 0.68 positive-igg 141.6 positive. 2.Toxo IgM 0.70 positive-igg 134.4 positive 3.Toxo IgM 0.79 negative-igg 1513.00 positive avidity70% grey?
See details: None of those result indicate active infection. They all indicate previous exposure. ...Read more
Hla gene mutations predispose one to developing autoimmunity after viral &/or vaccine exposure...Why not screen for mutations before vaccinating us?
Vaccine-preventable : Infections trigger clinical symptoms of auto-immune disorders far more often & more severely than do vaccines. The who's criteria for assessing adverse reactions to vaccines, including autoimmune diseases, are the consistency, strength & specificity of an association, not just a temporal relationship. Image.Thelancet.Com/.../02art9340web.Pdf discusses current & future epidemiology ...Read more
Mutations: A chromosome will contain many genes, so a chromosome mutation will effect many genes. A gene mutation will have an effect only on that gene. ...Read more