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Doctor insights on: Positive Ana Muscle Ache

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Positive ANA, 1:320, homogenous. Started testing due to high protein levels and symptoms of muscle aches, fevers, fatigue. Lupus?

Positive ANA, 1:320, homogenous. Started testing due to high protein levels and symptoms of muscle aches, fevers, fatigue. Lupus?

Not necessarily: A number of criteria have to be met to diagnose lupus.
Please consult this site for more information on this topic.
http://www.lupus.org/answers/entry/lupus-diagnostic-criteria
For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form.
Practice safe sex.
Get HPV vaccine. ...Read more

Muscle (Definition)

It is a body tissue that has the ability to contract. It shortens and generates force. It relaxes and returns to its original length. Muscles move joints, stabilize the body, move air and food through the organs, act as valves for bladder, bowel and other organs. They control movement of the eyes. They help us express ourselves by changing the shape of our ...Read more


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My muscles ache, I have a positive ANA & very low vitamin d, what could it be?

My muscles ache, I have a positive ANA & very low vitamin d, what could it be?

Not enough info: Diagnosis of rheumatologic conditions needs a complete interrogation about symptoms, timing of the symptoms and a great characterization of which population you belong (age, sex, race, ethnic background, etc). You also need to review family history, social history ad a complete physical examination. To know what you have with this little, any guess is as valid as any. ...Read more

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Muscle pain, butterfly rash, fatigue. Positive ANA and elevated rnp. Is this likely lupus?

Muscle pain, butterfly rash, fatigue. Positive ANA and elevated rnp. Is this likely lupus?

Very possible: It does fit the lupus picture. That being said, discuss this diagnosis as well as other possibilities with your rheumatologist. ...Read more

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PAD in legs. Increased joint muscle pain. High positive ANA homogeneous pattern. Stopped seeing Rheumy bcause I got frustrated with no diagnosis?

PAD in legs. Increased joint muscle pain. High positive ANA homogeneous pattern. Stopped seeing Rheumy bcause I got frustrated with no diagnosis?

UCTD: It may be early to be diagnosed with a specific rheumatologic disease such as lupus or sjogren syndrome. The higher the ANA titer the more confident that this is true. Muscle aches amy be the early presentation of an autoimmune disease which is evolving and it is variable how fast if at all it will evolve to declare itself into one distinct condition. Undifferentiated connective tissue disease. ...Read more

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Increased joint pain, fatigue, muscle pain, light rash on face. Positive ANA 1:160 Homogenous & 1:160 Speckled. Lupus? Why two ANA results?

One screening one: for the specific pattern. ANA is a general screening test. Speckled pattern is further refinement of the test, as there are multiple types of anti-nuclear antibodies. It may not be lupus. It requires multiple criteria to be met for the diagnosis. You should discuss it with the doctor who ordered the test. You may visit this site for info:
https://www.researchgate.net/publication/276353307_2015_ACRSLICC_Revised_Criteria_for_Diagnosis_of_Systemic_Lupus_Erythematosus ...Read more

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I have a positive ana, ena and anti ssa/ro along with joint pain, muscle pain, fatigue and numbness. How likely is it that I have SLE?

I have a positive ana, ena and anti ssa/ro along with joint pain, muscle pain, fatigue and numbness. How likely is it that I have SLE?

SLE: All these are signs of some inflammatory disease of which SLE is one type. There are other markers to further identify the specific type of disease, and along with a complete physical exam and some tissue studies may pin down a specific diagnosis. However, there is no one specific test that marks SLE conclusively. ...Read more

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Recent ana, low titer. Positive rnp. No raynauds. Muscle aches, joint pains, severe heartburn, pleurisy 3 times last year, enlarged liver, heart races?

Positive RNP: Occur in around 50% of patients with lupus and in patients with other connective tissue disease notably mixed connective tissue disease. Diagnosis of sle depend on recognition of characteristic multisystem disease and exclusion of infection and malignancy. Mctd characterized by overlapping clinical features of sle, polymyositis, systemic sclerosis and high titters of anti-rnp. See a rheumatologist. ...Read more

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+ana of 1:320.Now 1:640 with distinct flares of joint pain, exhaustion, muscle aches, chest pain.Photosensitive, sicca.Complete workup neg.Common in ctds?

+ana of 1:320.Now 1:640 with distinct flares of joint pain, exhaustion, muscle aches, chest pain.Photosensitive, sicca.Complete workup neg.Common in ctds?

Uncertain : Even though you say that workup is negative, some laboratories don't get it right. Ask your rheumatologist what else can be done to evaluate the situation. ...Read more

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What are possible causes of repeated ANA 1:640 where prednisone helps symptoms of rashes, fatigue, dizziness, jt &muscle aches when all other labs are (-)?

What are possible causes of  repeated ANA 1:640 where prednisone helps symptoms of rashes, fatigue, dizziness, jt &muscle aches when all other labs are (-)?

Lupus most likely: You are describing a complex of symptoms and findings consistent with lupus. The positive ana, rash and joint pain gives you a 75% likelihood fo having lupus. All these symptoms are responsive to prednisone. Looking for other possible areas of involvement such as blood or kidney abnormalities is important. See a rheumatologist. ...Read more

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I have had debilitating joint and muscle pain for 9 months. I now have a sore in my nose. My ANA was 1:320 but DNA was neg. lupus or coincidence?

See rheumatologist: An elevated ANA suggests that you may be at risk for developing an autoimmune disease. If you have debilitating pain, you need to consult a rheumatologist. ...Read more

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Advice please symptoms: red rash & spider ang. On chest & face, cvi, raynauds, joint pain stiff.& muscle aches, diffuse hair loss. Rf & sr low ANA - ?

Advice please symptoms: red rash & spider ang. On chest & face, cvi, raynauds, joint pain stiff.& muscle aches, diffuse hair loss. Rf & sr low ANA - ?

Mixed CTD: Sure sounds like a possible mixed connective disease syndrome even though serologies negative --- would refer to rheumatologist. ...Read more

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I have recurring flares of rashes, joint pain, muscle aches, debilitating fatigue, dizziness. I have photosensitity and one episode of my WBC at 2.0 years back. My ANA is 6:40. I'm on plaquenil. Why are all my other antibodies neg for lupus?

I have  recurring flares of  rashes, joint pain, muscle aches, debilitating fatigue, dizziness. I have photosensitity and one episode of my WBC at 2.0 years back.  My ANA is 6:40.  I'm on plaquenil. Why are all my other antibodies neg for lupus?

Maybe SLE maybe not.: Diagnosis of rheumatologic disease is generally based on symptoms with support from lab. Sounds like you have a rheumatologic disease and are being treated with a rheumatologic agent perhaps by a rheumatologist. They can explain your particular situation better, but suffice it to say tests are not always right and a single test does not generally make or break a diagnosis. ...Read more

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If you have fibromoalga would that cause weak positive ANA test or MS nothing elsa comes up on tests but have ache joints on amtriptaline for pain?

Comments: Fibromyalgia does not affect ANA, and many normals have low titer tests. Perplexed why you are using amitryptyline, as no good evidence of value in fibromyalgia. Better drugs include gabapentin, Lyrica, Cymbalta, Savella (milnacipran). Does not sound like you have MS. ...Read more

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Last few months i've been real tired sore all over esp knees and stiff but no swelling what could be wrong I do have a positive ANA and low vit d?

Maybe autoimmunity: You don't say how high your ANA is. There is an important difference between muscle pain and joint pain. I doubt that the low vitamin d accounts for everything but having a normal vitamin d would be a good idea. You need further laboratory evaluation, Ibuprofen is often helpful in this setting. ...Read more

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How worried should I be about a positive ANA diffuse patern titer 1:640. Aches and pains in the morning that diminish with movement. Negative rf...?

How worried should I be about a positive ANA diffuse patern titer 1:640.  Aches and pains in the morning  that diminish with movement.  Negative rf...?

ANA is just a blood : ANA is just a blood test. It all depends on your evaluation. Your rheumatologist will evaluate the bloodwork and the clinical findings and see if there is a specific diagnosis and treatment. ...Read more

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I have fibromyalgia and positive ana.Feel ill like have the flu .Tired sore.If someone hugs me or if my kid lays on me it feels relief from soreness?

I have fibromyalgia and positive ana.Feel ill like have the flu .Tired sore.If someone hugs me or if my kid lays on me it feels relief from soreness?

Get second opinion: Patients with fibromyalgia typically feel excruciating pain if anyone as much as touches their tender points for trigger points lightly. Does not sound to me like you have fibromyalgia. The ANA being positive is of course of concern. I would recommend that you get a second opinion. Best wishes to you. I would get a second opinion from a board-certified rheumatologist. ...Read more

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I had a positive Ana twice (1:320) with homogenous and speckled patterns, C3 low (95 when standard is 98). Sore, tired, fevers, heart prob-what is it?

Rheumatologist!: Hi. Hey, do I look like a rheumatologist to you? Ha! Just kidding. But seriously, it's probably something in the lupus family...and it's a BIG family (although outside of my specialty). See a rheumatologist. You've got Sansum right there, and they're really good. Good luck! ...Read more

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I have PAD in legs. Positive ANA. Increased muscle joint pain stiff. How do my rheumy work up disease if one at all? Stopped seeing rheumy 4 mos ago.

I have PAD in legs. Positive ANA. Increased muscle joint pain stiff. How do my rheumy work up disease if one at all? Stopped seeing rheumy 4 mos ago.

See your rheumatolog: Your PAD may actually represent vasculitis, inflammation in the blood vessels. This would fit with a positive ANA and joint and muscle pain. You need to be reevaluated for proper treatment ...Read more

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What would cause a high positive ANA (1:640) speckled, nucleolar with a low positive smooth muscle antibody (1:40) but negative SS-A, SS-B, anti-Smith, RNP, SCL-70, Anti Jo antibodies? Liver disease?

Probably normal: Many people have a positive ANA without being sick. If you also have elevated liver enzymes, a workup for autoimmune hepatitis may be continued, but if there's nothing to suggest a liver problem biochemically, I'd not be in a hurry to diagnose despite anti-smooth-muscle. ANA means nothing apart from the clinical picture. Best wishes. ...Read more

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I have PAD in legs. Increased muscle joint pain. Positive ANA. What are early signs of autoimmune flare? I have a rheumy but stopped seeing her.

Go See Rheumy: And by Rheumy, I mean your rheumatologist. Positive ANA as my wife commonly states (rheumatologist) is not diagnostic of anything and can be positive in a variety of conditions. Honestly your rheumatologist is the best person to interpret a flareup vs. other. ...Read more

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A positive ANA test, vitamin d deficient, anemia, body aches, and high sed rate. Could all of these symptoms be caused from celiac?

A positive ANA test, vitamin d deficient, anemia, body aches, and high sed rate. Could all of these symptoms be caused from celiac?

No: Celiac disease can cause vitamin d deficiency and anemia, but it's not associated with a positive ANA test. Most patients with celiac have a normal sed rate. Vitamin d deficiency is often associated with myalgia. Celiac disease is an autoimmune disease, and having one autoimmune disease increases your chances of having another one, such as lupus, which can explain your posiitve ANA and body aches. ...Read more

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I have anemia, vitamin d deficient, positive ANA test, high sed rate, body aches, complement component c3c is 220, c4c is 51, c-reactive is .97explain?

I have anemia, vitamin d deficient, positive ANA test, high sed rate, body aches, complement component c3c is 220, c4c is 51, c-reactive is .97explain?

More than one issue: You did not state your age or gender and it is difficult to tie all the findings together without a physical examination. Vitamin d is the easiest to deal with, about 1/3 of the population has low vit d levels, and you can correct that with an over the counter supplement. Rest of the finding suggest and autoimmune process, but you need to consult a physician for a thorough evaluation. ...Read more

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Mid upper back pain for months right flank sore. Lupus panel neg . Ana positive 1;640 w/spec pat. Sed rate elevated. Serum protein normal. Any ideas?

Too many tests?: Your ANA is strongly positive, but despite that, it is a non-specific finding, and so is the elevated esr. These findings may not have anything to do with your complaints of back and flank pain. The provider(s) that ordered these tests will have to try and come up with a clinically plausible explanation. ...Read more

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Diagnosed with peripheral artery disease in legs. Abnormal echogram in heart positive ANA. Memory loss and chest pain and achy sore feet .help. legs?

Neurologist: Memory problems, leg pain. A general neurologist may be able to address both of these. Unfortunately there are only 5 neurologists in Florida who are certified in Behavioral Neurology (memory disorders) (Two in Jacksonville, two at the University of Florida in Gainsville and one in St Pete. The leg pain may be in part due to neuropathy. The ANA being positive must be taken with a grain of salt. ...Read more

Ana (Definition)

An "ana" is a blood test used to screen a person for the possibility of several autoimmune diseases. It is important to remember that this is a screening test and a positive result only indicates more testing may be warranted. No blood test is perfect, and getting to a diagnosis is usually much more complex than drawing blood and looking at a number ...Read more


Dr. Raj Upadya
954 doctors shared insights

Muscle Pain (Definition)

Also known as myalgia, muscle pain is a result of overuse or stretching of the muscle. Muscle pain can occur either becuase of an infection or because of a mechanical injury. It can be acute, or chronic pain that ...Read more