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Doctor insights on: Positive Ana Genetic Marker

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Can a positive ANA (going up for years, now 1/640) be insignificant if other autoimmune markers are negative?

Can a positive ANA (going up for years, now 1/640) be insignificant if other autoimmune markers are negative?

Probably not: If you don't have symptoms but why are they checking it?? Ask the person who ordered it to be sure. They know you and your history . ...Read more

Genetic (Definition)

From a medical standpoint, "genetic" refers to the potential heritability of various medical conditions. While some conditions are inevitable (at some point in one's life) as a consequence of simple genetic heritability (eg huntington's disease), a large number of medical conditions (including all behaviorial health disorders) are the expressed final pathway of a ...Read more


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Started me on plaquenill due to symptoms (no dryness)low positive ana. He mentioned markers for sjogrens then he spoke of lupus.Gave no diagnose?

Started me on plaquenill due to symptoms (no dryness)low positive ana. He mentioned markers for sjogrens then he spoke of lupus.Gave no diagnose?

see details: What symptoms do you actually have? Without this information, it is impossible to answer. If it is just GI issues, get another opinion. Plaquenil, (hydroxychloroquine) however, is commonly used as a first-line agent to treat lupus. ...Read more

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Ana positive 160 poss mtcd w/o lupus markers. What can cause 300 mg/dL lambda 200 lambda if no paraprotein? Check igd/e? Urine spot lambda bjp found

BJP: Bence Jones proteins, light chain, occur in multiple myeloma , lymphomas/chronic leukemias, monoclonal gammopathy of undetermined significance which can go on to myeloma at the rate of only 1%/yr -small risk),amylodosis,cryoglobunemia, Autoimmune disease can give false positive. Check IFE & bone marrow http://www.livestrong.com/article/372234-about-multiple-myeloma-and-bence-jones-protein/ ...Read more

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What can I expect to come next? I've a positive p-anca positive c-anca and positive ana! What does this really mean?

What can I expect to come next? I've a positive p-anca positive c-anca and positive ana! What does this really mean?

Talk to rheum: You need to consult a rheumatologist . Even though the positive tests point to the presence of vasculitis, by themselves they have no meaning. ...Read more

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Positive ANA 1:80 speckeled, p.O.T.S syndrome, fat malabsorption, would this link to scelerderma, i cannot think of any other issue, :-( that connects?

I doubt it: In the absence of raynaud's / skin changes prior to malabsorption, i'd be surprised if this was scleroderma. ANA especially at low-titer 1:80 very likely means nothing. Other causes of malabsorption are fairly common & can be worked up. Mild orthostatic tachycardia is probably more common than we think. I appreciate your research but i'd keep looking for answers & staying optimistic. ...Read more

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What is ANA positive means?

What is ANA  positive means?

Family practice : ANA , antinuclear antibody, testing is ordered to help detect auto immune disorders. It is a screening test and if positive prompts you to go further to detect causes. Lupus for one but there are others. ...Read more

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Is a positive ANA of 1/320 high?

Yes.: This is relatively high as it had to be diluted by 320 times. So this means it was very concentrated. Labs vary on what their cutoff for positive ANA is, but in all likelihood, this would be considered positive or high. It might not mean anything though, as even healthy, unaffected people can have a positive result as can those with viral infections, medicated, and with cancer can have it. ...Read more

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My ANA is positive 1:640 speckled. My ruemtoligist said everything she tested me for was neg. She said 70%women have positive ANA . Recheck?

No: Not unless your rheumatologist wants to recheck. A majority of adult women have ANA positive but this titer is a little bit high. However, it means nothing in the absence of other persuasive evidence of lupus or other autoimmune illness. We're not going to treat or not treat based on an ana. As a pathologist dedicated to lab nedicine, i always tell folks, "look at the person, not the numbers.". ...Read more

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Hiv cause positive ana?

Hiv cause positive ana?

See below: Any viral infection can cause a positive ANA but a large number of patients have a false positive ANA without any identifiable cause. ...Read more

Ana (Definition)

An "ana" is a blood test used to screen a person for the possibility of several autoimmune diseases. It is important to remember that this is a screening test and a positive result only indicates more testing may be warranted. No blood test is perfect, and getting to a diagnosis is usually much more complex than drawing blood and looking at a number ...Read more


Marker (Definition)

A "marker" is a protein or enzyme that can represent a disease process. Some markers are specific for a particular disease, while ...Read more