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Doctor insights on: Positive Ana And Rnp Antibodies

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What does a weakly positive ANA with only rnp antibodies indicate?

What does a weakly positive ANA with only rnp antibodies indicate?

Specific to patient: The test by itself is not diagnostic. It depends on your evaluation, examination, clinical factors are the most pertinent. The lab reports are guidelines but not diagnostic in themselves. ...Read more

Ana (Definition)

An "ana" is a blood test used to screen a person for the possibility of several autoimmune diseases. It is important to remember that this is a screening test and a positive result only indicates more testing may be warranted. No blood test is perfect, and getting to a diagnosis is usually much more complex than drawing blood and looking at a number ...Read more


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My lab tests came back with a positive ANA and positive rnp antibodies...Are these normal?

No.: Positive anas can be "false" positive. On the other hand an rnp antibody is not false. This combination would indicate mixed connective tissue disease. That having been said, I have many patients with a low titer rnp positivity and no signs of disease. ...Read more

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I have a weakly positive ANA which show rnp antibodies...I have an extremely slow motility. Swollen fingers. Red palms. Could this be mctd?

I have a weakly positive ANA which show rnp antibodies...I have an extremely slow motility. Swollen fingers. Red palms. Could this be mctd?

Positive RNP test: Mixed connective tissue disorder or mctd is an autoimmune disease, cousin to lupus and other diseases. Fatigue, joint swelling, sjogren syndrome, raynaud's phenomenon (spasm of arteries in fingers), are common findings. Blood tests show a positive ANA and often positive rnp antibodies. The diagnosis and treatment are usually carried out by a rheumatologist. ...Read more

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Went to dr with hand, shoulder, hip joint pain. Ana reflex screen Ana positive 1.0 and rnp antibody positive 4.3. All others neg. Very scared!

Went to dr with hand, shoulder, hip joint pain. Ana reflex screen Ana positive 1.0 and rnp antibody positive 4.3. All others neg. Very scared!

Lab numbers: These numbers don't show changes at joints and with most auto immune disorders, you may have periods of pain and increased lab numbers, usually related to stress in your life, and once treated medically or with stress reduction, pain/lab should improve. May want xray of one of involved joints just inflamed which can return to baseline. ...Read more

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What could a negative ANA and positive RNP antibodies mean? I have a history of chronic rheumatological symptoms, but my dr is not convinced its MCTD.

What could a negative ANA and positive RNP antibodies mean? I have a history of chronic rheumatological symptoms, but my dr is not convinced its MCTD.

Lab problem: The ANA screening test is fraught with pitfalls, and if you have a way-high titer of U1-RNP on the tube test and symptoms / signs of mixed connective tissue disease (which is a rough thing) but ANA is negative, perhaps there's a problem with the substrate. Your physician will want to call the lab's pathologist -- he / she would be interested in knowing. Best wishes. ...Read more

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In my labs it shows a positive ANA and then the lab automatically checks for antibodies...The only one was a low positive rnp. What does that mean?

Not a great deal.: Positive anas can be "false" positive. On the other hand an rnp antibody is not false. This combination would indicate mixed connective tissue disease. That having been said, I have many patients with a low titer rnp positivity and no signs of disease. Mctd is rarely a disease with major serious issues as other dx. ...Read more

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Positive ANA....Positive SM Antibody of 39 units....Positive RNP of 32 units. What would these numbers mean in comparison to tiers or to Lupus? N

Positive ANA....Positive SM Antibody of 39 units....Positive RNP of 32 units. What would these numbers mean in comparison to tiers or to Lupus? N

See below: SM antibodies are specific for systemic lupus and are often associated with anti-RNP antibodies. They are commoner in Blacks and Asians. It is not an indicator of severity or predictor of organ involvement, which requires careful history, physical and other tests, preferably in the hands of a certified rheumatologist. ...Read more

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What would cause a high positive ANA (1:640) speckled, nucleolar with a low positive smooth muscle antibody (1:40) but negative SS-A, SS-B, anti-Smith, RNP, SCL-70, Anti Jo antibodies? Liver disease?

Probably normal: Many people have a positive ANA without being sick. If you also have elevated liver enzymes, a workup for autoimmune hepatitis may be continued, but if there's nothing to suggest a liver problem biochemically, I'd not be in a hurry to diagnose despite anti-smooth-muscle. ANA means nothing apart from the clinical picture. Best wishes. ...Read more

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Can mixed connective tissue disease be diagnosed with a positive ANA and positive rnp anitibodies?

NO.: You must have a compatible clinical picture first and the absence of another diffuse connective tissue disorder which could explain the symptoms and lab findings. A high titer ANA and anti-u1-rnp is a pretty good marker of mctd though. ...Read more

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I just had my autoimmune panel come back with ANA Direct positive abnormal and RNP antibodies 1.3, I also have hair loss, fatigue is it lupus?

I just had my autoimmune panel come back with ANA Direct positive abnormal and RNP antibodies 1.3, I also have hair loss, fatigue is it lupus?

Need more info: There are eleven criteria that are evaluated for diagnosis of lupus and at least 4 of those need to be met. You may consult this site for more information on this topic:
http://lupusresearchinstitute. Org/lupus-facts/lupus-diagnosis ...Read more

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Is it possible to have positive ANA and RNP of 6.8 and not have autoimmune disease?

Yes they can: Yes it is - ANA can be false positive and so can RNP. However, the level of RNP is high so the question is - why did you have these tests done? Are there symptoms such as skin rash, joint pains, etc. ...Read more

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My blood test was positive ANA and high rnp what does that mean?

My blood test was positive ANA and high rnp what does that mean?

See below: These test results have to be interpreted in context of your symptoms and these are frequently false positives. Seeing a rheumatologist can help you better determine this. If they are a true positive, this can be seen with an autoimmune disease known as mixed connective tissue disease. ...Read more

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Can there be false positive rnp antibody tests even with a high titre of an ana?

FALSE POSITIVE RNP: It is possible
we need to know what your symptoms and signs are, and why the tests have been ordered. The lab test apways have to be interpreted along with complete clinacal findings
if you have signs and symptoms of lupus, high ana, and doctor ordered rnp to confirm the diagnosis and it comes out positive. That in all probabilities is positive and not false positive. ...Read more

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ANA positive SSA SSB weekly positive SCL weekly positive RNP SM weekly positive. Any implications? What are the differential diagnosis? WaDoes it mean

ANA positive SSA SSB weekly positive SCL weekly positive RNP SM weekly positive. Any implications? What are the differential diagnosis? WaDoes it mean

Pos auto ab tests: You are describing positive tests for auto antibodies. The differential diagnosis can be extensive. I am assuming a rheumatologist has ordered these tests? You need f/u with them to educate you what they mean, what further tests may need to be done and review your symptoms. Proper rheum DX is not based only on test results, but exam findings and symptoms of patient. Good luck. ...Read more

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I have a positive ANA and positive rnp. Does this inicate connective tissue disease?

Suggestive: Rheumatology has more tests yet depends less on them than perhaps any other specialty with challenging diagnoses. The titer of your ana, and more importantly your symptoms, will help your rheumatologist determine whether you actually have lupus or mixed-connective tissue disease, or one of the others, or are just someone who makes the antibodies and is healthy. Good luck. ...Read more

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I have a positive ANA and positive rnp. Does this inicate connective tissue disease?

Can't tell: These blood tests are just tests, and specific diagnoses have complex criteria. Your doctor can explain more fully. Positive ANA can be related to medication and is found is many conditions. ...Read more

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Can a person have mixed connective tissue disease with a positive ANA and low positive rnp levels?

Inprobable: Hight titers of anti rnp antibodies are the trade mark of mctd however it is possible to be in early phase of transformation from a lupus background were other anas are still dominant.
The clinical picture would take precedent with overlapping signs such as raynaulds, myositis and other signs of scleroderma.
None of these tests are diagnsotic in the absence of clinical illness. ...Read more

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I'm having negative DNA, Sm and Rnp antibodies, but positive sm/rnp antibody, and high ANA titre speckled, so what is the diagnosis?

Lupus: These serologies are rather non specific. The speckled ANA is non specific. In Systemic Lupus Erythematosis (SLE) it is usually homogeneous in its staining. Anti-Sm and Anti RNP can be see in mixed connective-tissue diseases and overlaps with SLE, scleroderma and myositis. As often is the case a specific diagnosis cannot be made. You need to see a Rheumatologist. ...Read more

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Can you tell me what can ANA positive & rnp 1.1 mean?

Probably nothiung: If it is just the ANA screen that is positive, it means nothing. An rnp of that level definitely means nothing. Why wre the tests ordered in the first place? ...Read more

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What does this mean? Ana positive 1:80 and bordering rnp?

Probably nothing: These results are unimpressive and likely mean nothing. The results should be evaluated in the context of the clinical symptoms. Ask the doctor who ordered them if they mean anything. If unsure, see a rheumatologist. ...Read more

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After testing I have ANA positive and rnp positive (1.4). What could this mean? ?

Context: If the titers are both 1:4 and you do not have obvious lupus or mixed connective tissue disease, then i'd bet they mean little or nothing. Diagnosis in rheumatology is based on history and physical exam, with labs just for confirmation. ...Read more

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Positive ana positive rnp low positive ccp positive dsdna can you tell me if this means lupus or mctd?

?: Depends on the clinical picture as well, results point towards auto immune disorder, but need to be put in clinical context and follow up to commit to a diagnosis ...Read more

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What would diagnosis be with test results 1:160 ANA- Positive-Speckl C4 Complement- 13 mg Anti-DS-DNA - 3 IU SM antib- 7 Index RNP Anti-5 SS-A-3

Part of the picture: Those lab results should be put in perspective, what are the symptoms and signs present, the best to judge / give a diagnosis is the doctor who ordered the blood tests, all these results can just be insignificant in absence of other criteria, best wishes ...Read more

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I recently tested positive for rnp antibodies. I have in the past tested positive for ana. My symptoms: rashes, weakness, pain. Your interpretatio?

I recently tested positive for rnp antibodies. I have in the past tested positive for ana. My symptoms: rashes, weakness, pain. Your interpretatio?

DEPENDS: Could be mixed connective tissue disease which combines features of scleroderma, myositis, systemic lupus erythematosus, and rheumatoid arthritis (with some sources adding polymyositis, dermatomyositis, and inclusion body myositis). Additional testing for the muscle enzymes, rheumatoid factor, echocardiogram (pulmonary hypertension) and other extractable nuclear antigens may help differentiate. ...Read more

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Sm/rnp antibody- ANA choice- positive, speckled/titer: 1:1280; sm & rnp (done alone) negative; sm/rnp antibody (together?) positive 3.0 guessing mctd?

Heads up: One of the things that's frustrating about these antibody tests looking for different connective tissue diseases is that they are difficult to do and are fraught with pitfalls. I suspect you've had at least one lab error to complicate your workup. Have you have a tube test for u1-rnp? Your clinical symptoms and signs actually tell more about your diagnosis ; best direction for treatment. ...Read more

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If I have a high positive ANA (1:640) speckled, nucleolar and low positive SMA (1:40), what further tests do I need to do? (Negative SS-A, SS-B, Smith, RNP, SCL-70, Anti Jo Abs)

If I have a high positive ANA (1:640) speckled, nucleolar and low positive SMA (1:40), what further tests do I need to do? (Negative SS-A, SS-B, Smith, RNP, SCL-70, Anti Jo Abs)

? anti dsDNA: You've probably already had these more basic tests: complete blood count, sedimentation rate, C-reactive protein, urinalysis & rheumatoid factor. It appears to me that the ANA results with slight positive anti-Smith may suggest lupus; you need an antibody to double-stranded DNA (anti dsDNA) which is very specific & somewhat sensitive for lupus. All this needs to be correlated by your doc/specialist ...Read more

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Positive ANA (low titers) with positive rnp. Dx'd so far with hashi's, fibro, and raynaud's. Should I see a rheumy for the pos ANA and rnp?

Positive ANA (low titers) with positive rnp. Dx'd so far with hashi's, fibro, and raynaud's. Should I see a rheumy for the pos ANA and rnp?

Yes: Autoimmune diseases typically are managed by rheumatology... Steroids and other types of immune-modulators assists in temporizing these challenging diseases. ...Read more

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ANA w reflex positive A direct 5 ; RNP antibodies 3.2 H. All other labs normal/negative. Rheumatologist says it's nothing, should I worry?

What for?: Do you have any symptoms? All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, your results and your doctor's opinion appear to be in sync and you should not worry.
For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form.
Practice safe sex, if you have sex. ...Read more

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I had a positive HLA B27, positive ANA, positive SM anitobody, and a positive RNP. And Raynauds, is this likely Lupus?

I had a positive HLA B27, positive ANA, positive SM anitobody, and a positive RNP. And Raynauds, is this likely Lupus?

Lupus is a clinical: Diagnosis, made based on the presence of physical symptoms and specific organ involvement and is not a diagnosis made by the presence of a genotype or auto antibody. What symptoms have you had that prompted your physician to do this series of tests? What is the opinion of the rheumatologist seeing you (or are you still awaiting a visit with rheum?) These disorders are complex/overlap. Talk w/ URMD ...Read more

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Positive ANA 1:320 speckled and rnp 1.0. What does this mean? I feel fine no joint pains. Only pains I have is some back pain and mild lower side pain

Positive ANA 1:320 speckled and rnp 1.0. What does this mean? I feel fine no joint pains. Only pains I have is some back pain and mild lower side pain

Maybe a false posit: It maybe a false positive as your current symptoms are not consistent with symptoms associated with those positive antibodies. See a rheumatologist to confirm. ...Read more

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What if ANA positive, sm/rnp positive, sm negative and rnp negative with symptoms of joint pain/swelling/burning and hives?

What if ANA positive, sm/rnp positive, sm negative and rnp negative with symptoms of joint pain/swelling/burning and hives?

See details: A negative ANA and sm antibody makes lupus unlikely but not impossible. Of course there are other numerous causes of an inflammatory arthritis. See a rheumatologist. ...Read more

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I have had positive ANA and high rnp tests, rosacea, multiple surgeries for massive scar tissue in multiple organs, interstitial cystitis, can I have sle?

I have had positive ANA and high rnp tests, rosacea, multiple surgeries for massive scar tissue in multiple organs, interstitial cystitis, can I have sle?

Many possibilities.: Lupus is certainly possible with +ana and high rnp, rosacea, but so are other diseases. Scleroderma can have +ana and fibrosis/scarring of many organs. Sarcoidosis also can have granulomas of many organs that can appear to be scars and purple lesions on the face, fingers, and knees and would need biopsy for diagnosis. Sjogren's syndrome also has high rnp, +ana, and dry eyes, mouth, and skin. ...Read more

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Muscle pain, butterfly rash, fatigue. Positive ANA and elevated rnp. Is this likely lupus?

Muscle pain, butterfly rash, fatigue. Positive ANA and elevated rnp. Is this likely lupus?

Very possible: It does fit the lupus picture. That being said, discuss this diagnosis as well as other possibilities with your rheumatologist. ...Read more

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I have a positive ANA 1:160 Homo pattern & RNP of. 3. Joint pain, limb numbness, skin indents stay for hours, bruising. No diagnosis. More testing?

I have a positive ANA 1:160 Homo pattern & RNP of. 3. Joint pain, limb numbness, skin indents stay for hours, bruising. No diagnosis. More testing?

You need to: See a BOARD CERTIFIED RHEUMATOLOGIST for some further tests and a definitive diagnosis!


Ask your Primary Care Provider (PCP) for a referral!

Hope this helps!
Dr Z ...Read more

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I have ibs-c with pain, take Prozac (fluoxetine) & amitryptline. Also had joint pain &tired. Tested got ANA positive and rnp positive (1.4). What could this mean?

I have ibs-c with pain, take Prozac (fluoxetine) & amitryptline. Also had joint pain &tired. Tested got ANA positive and rnp positive (1.4). What could this mean?

See below: ANA is one part of detecting if there is an autoimmune disorder present. Your doctor can examine you to determine if the tests are confirming diagnosis from your symptoms and the exam.

Please refer to this site for more info:
http://www. Ncbi. Nlm. Nih. Gov/pubmedhealth/pmh0004004/. ...Read more

Antibody (Definition)

An antibody is a protein the body's immune system makes to identify potentially harmful substances in the body. Antibodies attach to the substance on a molecular level and mark it so the immune ...Read more


Dr. Tanya Russo
80 Doctors shared insights

Rnp Antibody (Definition)

Http://www. Mayomedicallaboratories. Com/test-catalog/clinical+and+interpretive/81357. ...Read more