Doctor insights on:
Positive Ana And Rnp Antibodies
Specific to patient: The test by itself is not diagnostic. It depends on your evaluation, examination, clinical factors are the most pertinent. The lab reports are guidelines but not diagnostic in themselves. ...Read more
An "ana" is a blood test used to screen a person for the possibility of several autoimmune diseases. It is important to remember that this is a screening test and a positive result only indicates more testing may be warranted. No blood test is perfect, and getting to a diagnosis is usually much more complex than drawing blood and looking at a number ...Read more
I have a weakly positive ANA which show rnp antibodies...I have an extremely slow motility. Swollen fingers. Red palms. Could this be mctd?
Positive RNP test: Mixed connective tissue disorder or mctd is an autoimmune disease, cousin to lupus and other diseases. Fatigue, joint swelling, sjogren syndrome, raynaud's phenomenon (spasm of arteries in fingers), are common findings. Blood tests show a positive ANA and often positive rnp antibodies. The diagnosis and treatment are usually carried out by a rheumatologist. ...Read moreSee 1 more doctor answer
My lab tests came back with a positive ANA and a positive rnp antibodies...Is this considered abnormal readings?
Yes: You need to see a rheumatogist.Get a more detailed answer ›
Went to dr with hand, shoulder, hip joint pain. Ana reflex screen Ana positive 1.0 and rnp antibody positive 4.3. All others neg. Very scared!
Lab numbers: These numbers don't show changes at joints and with most auto immune disorders, you may have periods of pain and increased lab numbers, usually related to stress in your life, and once treated medically or with stress reduction, pain/lab should improve. May want xray of one of involved joints just inflamed which can return to baseline. ...Read more
What could a negative ANA and positive RNP antibodies mean? I have a history of chronic rheumatological symptoms, but my dr is not convinced its MCTD.
Lab problem: The ANA screening test is fraught with pitfalls, and if you have a way-high titer of U1-RNP on the tube test and symptoms / signs of mixed connective tissue disease (which is a rough thing) but ANA is negative, perhaps there's a problem with the substrate. Your physician will want to call the lab's pathologist -- he / she would be interested in knowing. Best wishes. ...Read more
I have positive ANA with positive anti-rnp antibodies 6.8. Extreme fatigue, joint pain, low grade fevers and profound weakness. Saw rheumatologist who said it was fibromyalgia and that positive RNP "means nothing." what are your thoughts?
In my labs it shows a positive ANA and then the lab automatically checks for antibodies...The only one was a low positive rnp. What does that mean?
Not a great deal.: Positive anas can be "false" positive. On the other hand an rnp antibody is not false. This combination would indicate mixed connective tissue disease. That having been said, I have many patients with a low titer rnp positivity and no signs of disease. Mctd is rarely a disease with major serious issues as other dx. ...Read moreSee 1 more doctor answer
Positive ANA....Positive SM Antibody of 39 units....Positive RNP of 32 units. What would these numbers mean in comparison to tiers or to Lupus? N
See below: SM antibodies are specific for systemic lupus and are often associated with anti-RNP antibodies. They are commoner in Blacks and Asians. It is not an indicator of severity or predictor of organ involvement, which requires careful history, physical and other tests, preferably in the hands of a certified rheumatologist. ...Read more
What would cause a high positive ANA (1:640) speckled, nucleolar with a low positive smooth muscle antibody (1:40) but negative SS-A, SS-B, anti-Smith, RNP, SCL-70, Anti Jo antibodies? Liver disease?
Probably normal: Many people have a positive ANA without being sick. If you also have elevated liver enzymes, a workup for autoimmune hepatitis may be continued, but if there's nothing to suggest a liver problem biochemically, I'd not be in a hurry to diagnose despite anti-smooth-muscle. ANA means nothing apart from the clinical picture. Best wishes. ...Read more
Can mixed connective tissue disease be diagnosed with a positive ANA and positive rnp anitibodies?
I just had my autoimmune panel come back with ANA Direct positive abnormal and RNP antibodies 1.3, I also have hair loss, fatigue is it lupus?
Need more info:
There are eleven criteria that are evaluated for diagnosis of lupus and at least 4 of those need to be met. You may consult this site for more information on this topic:
http://lupusresearchinstitute. Org/lupus-facts/lupus-diagnosis ...Read more
See below: These test results have to be interpreted in context of your symptoms and these are frequently false positives. Seeing a rheumatologist can help you better determine this. If they are a true positive, this can be seen with an autoimmune disease known as mixed connective tissue disease. ...Read more
FALSE POSITIVE RNP:
It is possible
we need to know what your symptoms and signs are, and why the tests have been ordered. The lab test apways have to be interpreted along with complete clinacal findings
if you have signs and symptoms of lupus, high ana, and doctor ordered rnp to confirm the diagnosis and it comes out positive. That in all probabilities is positive and not false positive. ...Read more
ANA positive SSA SSB weekly positive SCL weekly positive RNP SM weekly positive. Any implications? What are the differential diagnosis? WaDoes it mean
Pos auto ab tests: You are describing positive tests for auto antibodies. The differential diagnosis can be extensive. I am assuming a rheumatologist has ordered these tests? You need f/u with them to educate you what they mean, what further tests may need to be done and review your symptoms. Proper rheum DX is not based only on test results, but exam findings and symptoms of patient. Good luck. ...Read moreSee 2 more doctor answers
Suggestive: Rheumatology has more tests yet depends less on them than perhaps any other specialty with challenging diagnoses. The titer of your ana, and more importantly your symptoms, will help your rheumatologist determine whether you actually have lupus or mixed-connective tissue disease, or one of the others, or are just someone who makes the antibodies and is healthy. Good luck. ...Read more
Can a person have mixed connective tissue disease with a positive ANA and low positive rnp levels?
Hight titers of anti rnp antibodies are the trade mark of mctd however it is possible to be in early phase of transformation from a lupus background were other anas are still dominant.
The clinical picture would take precedent with overlapping signs such as raynaulds, myositis and other signs of scleroderma.
None of these tests are diagnsotic in the absence of clinical illness. ...Read more
I'm having negative DNA, Sm and Rnp antibodies, but positive sm/rnp antibody, and high ANA titre speckled, so what is the diagnosis?
Lupus: These serologies are rather non specific. The speckled ANA is non specific. In Systemic Lupus Erythematosis (SLE) it is usually homogeneous in its staining. Anti-Sm and Anti RNP can be see in mixed connective-tissue diseases and overlaps with SLE, scleroderma and myositis. As often is the case a specific diagnosis cannot be made. You need to see a Rheumatologist. ...Read more