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Doctor insights on: Positive Ana And Elevated Sedimentation Rate

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If I have a high positive ANA (1:640) speckled, nucleolar and low positive SMA (1:40), what further tests do I need to do? (Negative SS-A, SS-B, Smith, RNP, SCL-70, Anti Jo Abs)

If I have a high positive ANA (1:640) speckled, nucleolar and low positive SMA (1:40), what further tests do I need to do?  (Negative SS-A, SS-B, Smith, RNP, SCL-70, Anti Jo Abs)

? anti dsDNA: You've probably already had these more basic tests: complete blood count, sedimentation rate, C-reactive protein, urinalysis & rheumatoid factor. It appears to me that the ANA results with slight positive anti-Smith may suggest lupus; you need an antibody to double-stranded DNA (anti dsDNA) which is very specific & somewhat sensitive for lupus.All this needs to be correlated by your doc/specialist ...Read more

Ana (Definition)

An "ana" is a blood test used to screen a person for the possibility of several autoimmune diseases. It is important to remember that this is a screening test and a positive result only indicates more testing may be warranted. No blood test is perfect, and getting to a diagnosis is usually much more complex than drawing blood and looking at a number ...Read more


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A positive ANA of 1:80 titer Nucleolar pattern, 36 RF, 22 Sedimentation rate and a 3.0 hsCRP...could this be something?

 A positive ANA of 1:80 titer Nucleolar pattern, 36 RF, 22 Sedimentation rate and a 3.0 hsCRP...could this be something?

Nonspecific: This level of ANA is nonspecific but may be indicative of a mild autoimmune disorder but has to be interpreted in context of symptoms and physical findings. Your sed rate is not elevated and if you have no other findings, I doubt you have active inflammatory process going on. A rheumatologist is best qualified to evaluate and advise you about your status. ...Read more

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I have been tested with the following: sedimentation rate of 1, rf of <20, uric acid of 4.7 and a ANA speckled pattern of 1:160. Possible raynauds p?

I have been tested with the following: sedimentation rate of 1, rf of <20, uric acid of 4.7 and a ANA speckled pattern of 1:160. Possible raynauds p?

Raynaud's: Why were you tested? Raynaud's may not have any positive lab studies. If associated with scleroderma a scl 70 would likely be positive. A positive rnp would suggest mixed connective tissue disease. Raynaud's can also be unrelated to a connective tissue disease. Sometimes raynaud's is related to peripheral vascular disease. It can be a side effect of medications such as beta blockers. ...Read more

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I have been tested with the following: sedimentation rate of 1, rf of <20, uric acid of 4.7 and a ANA speckled pattern of 1:160. Possible raynauds p?

I have been tested with the following: sedimentation rate of 1, rf of <20, uric acid of 4.7 and a ANA  speckled pattern of 1:160.  Possible raynauds p?

Tip of the iceberg: You may well have raynaud's but this may just be a symptom of a larger picture. You may have something else as well. You need further testing to rule out a collagen vascular disease such as lupus or sjogrens. ...Read more

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What could cause chronic joint pain (most joints) in otherwise healthy 25 yo male? Rf, ana, treponema pallidum, sedimentation rate all normal.

What could cause chronic joint pain (most joints) in otherwise healthy 25 yo male? Rf, ana, treponema pallidum, sedimentation rate all normal.

Inflammation: Inflammation has many possible causes. There is the possibility of seronegative RA (ra test is negative); given that all of your tests are negative focus on nutritional causes. Stop all acid intake especially sodas; increase antioxidant intake and herbal antiinflammatories and a new product on the market that has been shown to reduce oxidative stress to near nothing. www.medacpc.com for more. ...Read more

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Neck CT "small cortical defect along the anterior aspect of the dens just below the anterior arch of C1 with adjacent bone or calcific density." Platelets - 487. ANA is neg. RA Factor - neg. C-Reactive Prot, Quant - 79.6. Sedimentation Rate-West - 47?

Lab results: hello ~ there is no history so impossible to comment. The CRP is non-specific and slightly up and ESR is non specific and slightly raised. Luckily the ANA and RA negative. The changes at ant ramus C2 and dens are nonspecific possibly due to osteo-arthritis. (ANA and RA shd not be routine labs!) If mets or myeloma in dd do bone scan. thanks ...Read more

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What is an elevated sedimentation rate?

What is an elevated sedimentation rate?

Marker of : Inflammation. Elevated ESR is a non-specific marker of inflammation, but not diagnostic of any particular disease. ...Read more

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What to do about rheumatoid factor: 1"60 titer, elevated erythrocyte sedimentation rate what is the preliminary diagnoses?

What to do about rheumatoid factor: 1"60 titer, elevated erythrocyte sedimentation rate what is the preliminary diagnoses?

Not rheumatoid: This may not be rheumatoid arthritis. Other medical causes can be the reason. We need more information. Your physician can clarify this ...Read more

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I realise that these markers aren't specific but wouldn't most advanced cancers cause elevated Sedimentation rate and C-reactive protein?

I realise that these markers aren't specific but wouldn't most advanced cancers cause elevated Sedimentation rate and C-reactive protein?

No: Nice to be able to help once again, Matt. The sed rate and especially the C-reactive protein result from the liver pumping out extra large amounts of a couple of particular proteins that are stimulated by very particular things that are often produced in inflammation and seldom in pure neoplasia. Forget most (not all) of what you've read about "immune response to cancer" as myth. Best wishes. ...Read more

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Crp and sedimentation rate are both independant indicators of inflammation, do we know to what problems continuous and elevated sr(2xmax) only lead ?

Crp and sedimentation rate are both independant indicators of inflammation, do we know to what problems continuous and elevated sr(2xmax) only lead ?

Many causes Hi SR: The sedimentation rate (sed rate) blood test measures how quickly red blood cells (erythrocytes) settle in a test tube in one hour. The more red cells that fall to the bottom of the test tube in one hour, the higher the sed rate. When inflammation is present in the body, certain proteins cause red blood cells to stick together and fall more quickly than normal to the bottom of the tube. These pro. ...Read more

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Sedimentation Rate (Definition)

A sedimentation rate is a lab test that can help to assess ...Read more