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Doctor insights on: Porcine Pancreatic Lipase

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Dr. Todd Igel
362 doctors shared insights

Lipase (Definition)

Lipases, such as lipoprotein lipase and endothelial lipase, are enzymes that breakdown circulating triglycerides (tg). Specifically, lipases degrade tg rich lipoproteins including chylomicrons, very low density lipoprotein (vldl) and remnant particles produced by breakdown of chylomicron and vldl particles. Decreased lipase function leads to accumulation of ...Read more


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I have elevated liver enzyme ast(sgot)412 ALT (sgpt) 317 GGT 186 dilation of the common bile duct 1 CM no gallbladder?

I have elevated liver enzyme ast(sgot)412 ALT (sgpt) 317  GGT 186 dilation of the common bile duct 1 CM no gallbladder?

Liver issue: Enzymes ast and alt are inside liver cells. When liver is injured by disease or medication, enzymes leak out, resulting in elevation. Can be due to many reasons, including medications like statins. An elevated GGT suggest biliary problems, but is not that specific. The normal common bile duct measures less than 0.8 cm, but after the gb is removed, can be 1cm. Complete history needed for this. ...Read more

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Which test is better for diagnosing pancreas insufficiency: stool panc elastase or serum lipase/amylase? Would either diagnose pancreatic cancer?

Which test is better for diagnosing pancreas insufficiency: stool panc elastase or serum lipase/amylase? Would either diagnose pancreatic cancer?

Both together: Neither of the tests alone tells much. A combination of tests and exams will lead to diagnosis. Pancreatic cancer is not able to be ruled out by any test or imaging study. It can only be absolutely proven by some form of biopsy. A ct guided needle or egd with brushing a may be the only way to find it. ...Read more

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Are liver and pancreatic enzymes always elevated with liver and pancreatic cancer?

Are liver and pancreatic enzymes always elevated with liver and pancreatic cancer?

Short answer: No: Most often if a malignant mass presses on the ductal system of liver or panc. (see picture), it can cause abn. blood enzymes. If the mass is small and ducts drain, routine enzymes are usually normal. Gilbert Syndrome, a genetic abn. of up to 7% of folks, has the significance like your fingerprints, and is discussed nicely in: http://ghr.nlm.nih.gov/condition/gilbert-syndrome ...Read more

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How accurate is pancreatic polypeptide In detecting pancreas tumor?

How accurate is pancreatic polypeptide
In detecting pancreas tumor?

NOT VERY!!!: Hi. Pancreatic polypeptide (PP) is NOT a screening test for pancreatic tumors. The only pancreatic cells that make PP are rare neuroendocrine cells in the Islets of Langerhans (an already tiny fraction of the pancreas). And those would be a TINY, TINY fraction of all pancreatic tumors. But hey, if it's a PP secreting neuroendocrine tumor of the pancreas, you'd have it dialed! Good luck! ...Read more

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How to diagnose pancreatic dysfunction? Amylase, lipase and insulin blood test?

History & physical: If the pancreas is inflamed or damaged, amylase and lipase are often up, and it's not subtle. If your pancreas isn't functioning properly, you'll be losing weight with no explanation and probably have diarrhea / steatorrhea. Your physician can check your stool for pancreatic enzymes. It's rare but with a suggestive history, a screen may show something that could respond to enzyme replacement. ...Read more

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What distinguishes pancreas, liver, colon, kidney, prostate and gallbladder cancers?

What distinguishes pancreas, liver, colon, kidney, prostate and gallbladder cancers?

Cure varies: Beyond the obvious differences in organ and cell type as well as the various treatment approaches, the most important patient difference is really the chance at cure. Early stage prostate and renal cell (kidney) cancers can be very curable. Even really early stage pancreatic cancers can be quite deadly. ...Read more

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Normal pancreatic enzymes, normal liver enzymes, normal CBC, normal ESR & C-RP. does this rule out pancreatic and liver cancer?

Normal pancreatic enzymes, normal liver enzymes, normal CBC, normal ESR & C-RP. does this rule out pancreatic and liver cancer?

Why do you ask?: Why would you think you have this stuff at age 20? You've written about this before. You owe it to yourself and those who love you to get with someone who can help you out these thoughts out of your mind and get on with studying, getting job skills and experience, perhaps finding romance and meaningful things to enjoy. To be brave, act brave. You're anything but helpless. ...Read more

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Panc elastase test shows insufficiency. Have fatty liver. Is pei cause of fatty liver? Is there connection between fatty liver and pancreatic cancer?

Panc elastase test shows insufficiency. Have fatty liver. Is pei cause of fatty liver? Is there connection between fatty liver and pancreatic cancer?

No, just description: Like most dx, just a label for a pattern, as judged by whatever metrics. Yes, there is observed relation between fatty liver ; developing liver cancer. Fatty liver most commonly due to persistent low-fat, hi-carb (i.e. All sugars, simple ; complex) foods. Liver, to protect rest of body from ?sugar (toxic), converts sugars into triglyceride fats. If can't export into external fat, then fatty liver. ...Read more

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Do gall stones raise liver enzymes?

Do gall stones raise liver enzymes?

They may: It is not unusual for patients to have slight elevations in their liver enzymes with gall stones. This is probably caused by sub clinical inflammation in the gall bladder. Significant elevations are seen in acute cholecystitis and elevation of the bilirubin can be due due common duct stones with obstruction. ...Read more

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Pancreatic cancer?I had a pancreatic protocol ct/hida/liver, pancreas, CBC blood test/stool test/colonoscopy.All perfect.I still have light/yellow stool

Pancreatic cancer?I had a pancreatic protocol ct/hida/liver, pancreas, CBC blood test/stool test/colonoscopy.All perfect.I still have light/yellow stool

Stop worrying: You have nothing to worry about except that fact that you are still a smoker, which i hope you'll stop. If everybody with light-colored stools consumed health-care dollars searching for pancreatic cancer, it'd be a huge waste. Evidently you're not even jaundiced. Please stop reading internet scare stuff, look for another cause of your abdominal pain ; stop reading internet scare stuff. ...Read more

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Which one of these enzymes are in gastric juices: amylase, protease, trypsin?

Which one of these enzymes are in gastric juices: amylase, protease, trypsin?

Trypsin: Protease is a general term of any enzyme that breaks down proteins and includes, trypsin, and chymotrypsin. ...Read more

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Mom has jaundice w elevated liver enzymes, and elevated amylase and lipase. Ct w contrast was done, no tumors seen. Could this be pancreatic cancer?

Mom has jaundice w elevated liver enzymes, and elevated amylase and lipase. Ct w contrast was done, no tumors seen. Could this be pancreatic cancer?

It is unclear: Hi kitten40047. The jaundice and elevated enzymes are concerning. It is reassuring to hear that the ct was negative. There may be other reasons for her symptoms. However, in the absence of any other explanation for the symptoms she has, you may want to have mom undergo additional tests, including perhaps MRI or endoscopy, which may shed more light on the pancreatic and liver areas. ...Read more

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Elevated lipase/amylase, no gallbladder, mrcp no infl of pancreas, liver lesion, not a drinker/smoker, only 32, was taking asacol (mesalamine) hd/colazal, opinion?

Elevated lipase/amylase, no gallbladder, mrcp no infl of pancreas, liver lesion, not a drinker/smoker, only 32, was taking asacol (mesalamine) hd/colazal, opinion?

See GI doctor: Its not clear whether you have pain / pancreatitis or how high your levels are. There's a lot of causes of pancreatitis including medicational side effect but it is best to have a GI doctor review your labs / imaging first. ...Read more

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Substrate name for lipase enzyme?

Substrate name for lipase enzyme?

Olive oil: At least that's what we used for assays when i was doing a lot of clinical chemistry. Today kitmakers sell you "lipase substrate" which the physician need only do quality control on. I suspect it's olive oil. ...Read more

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Gallstone, 31% EF, low total bilirubin, high anion gap, hx of elevated liver enzymes. Liver enzymes leveled out after taking hormones.causes? advice?

Gallstone, 31% EF, low total bilirubin, high anion gap, hx of elevated liver enzymes. Liver enzymes leveled out after taking hormones.causes? advice?

HF: you have complex issues. Why do you have HF and also the cause of liver disease ? The AGMA is concerning and has to be worked up. Some of these conditions can be related. What hormones did you take ? I have more questions than answers, more so because you have 2 organ dysfunction and a acid base disorder and they can be related. ...Read more

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Lfts worsening-serum gammagt level 647u/l, serum alk phosphate 654u/l.Othr blood/heps normal.Mri &scans done. 3polyps large14mm in gallbladder-remove?

Lfts worsening-serum gammagt level 647u/l, serum alk phosphate 654u/l.Othr blood/heps normal.Mri &scans done. 3polyps large14mm in gallbladder-remove?

See specialist: The elevation in ggtp and alkaline phosphatase in the setting of gallbladder polyps that large mandates that you see a liver specialist before embarking on surgery. There are two types of specialists you should see, a hepatologist, a liver internal medicine doctor to make sure this is not some type of hepatitis or liver disease and then a liver surgeon to decide if the polyp is cancerous. Do asap. ...Read more

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Dr. Al Hegab
3 doctors shared insights

Pancreas (Definition)

Abdominal organ. It is digestive organ: it secretes enzymes into the small bowel which break down food and help its absorption. It is also an endocrine organ: it produces hormones involved in sugar control and control of digestion. Insulin is one of these hormones. Diabetics either lack Insulin (type 1 diabetes) or have inadequate ...Read more