Top
40
Doctor insights on: Poorly Differentiated Squamous Cell Lung Cancer

Share
1

1
Could you explain what is non squamous cell lung cancer?

Could you explain what is non squamous cell lung cancer?

Broad category: There two main types of lung cancer, small cell and non-small cell. Squamous cell is one type of non-small cell lung cancer, so that leaves a large variety. See these sites for more info.

http://www. Cancer. Gov/cancertopics/pdq/treatment/non-small-cell-lung/patient/page1
http://www. Mayoclinic. Com/health/lung-cancer/ds00038. ...Read more

Dr. Barry Rosen
4,351 Doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


2

2
What exactly is squamous cell carcinoma lung cancer?

What exactly is squamous cell carcinoma lung cancer?

One type of cancer: There are a number of variants of lung cancer and these are named for their microscopic appearance, the main ones being: squamous cell, adenocarcinoma, small cell carcinoma and large cell carcinoma. In squamous cell cancer, the tumor cells resemble skin cells. This type of tumor is commonly seen in smokers. ...Read more

3

3
What is poorly differentiated squamous cell cancer?

What is poorly differentiated squamous cell cancer?

Very malignnt.: This is a kind of squamous cancer that is poorly organized, or has no resemblance to what squamous lining should look like. It follows that this is a very serious cancer that must be treated very aggressively for any chance of a favorable outcome. ...Read more

4

4
What is recommended follow up for lung cancer (squamous 2a) after 5years?

What is recommended follow up for lung cancer (squamous 2a) after 5years?

Unclear: After 5 years the chance of recurrence is low. However, individuals who have had one lung cancer, are at risk for developing a separate, new unrelated lung cancer. Therefore surviviors after 5 years should probably get yearly low dose chest ct scans. ...Read more

5

5
Hist chest pain and hemopsys. Normal CXR CT shows calcified hilar node. Ca of 10.8 now 9.7 Dr Doesn't think Squamus lung cancer no smoker Bronchoscopy?

Hist chest pain and hemopsys. Normal CXR CT shows calcified hilar node. Ca of 10.8 now 9.7 Dr Doesn't think Squamus lung cancer no smoker Bronchoscopy?

See below: Is this your PCP or pulmonologist saying this? There are many causes of enlarged hilar lymph nodes. Also, if it is calcified, that is usually just a sign of old granulomatous disease, like histoplasmosis. And at 31, that would be unusual to have lung cancer - not unheard of - but unusual. ...Read more

7

7
Mom=cancer mets in lungs and liver. Prim tumor squamous cell in sm bowel. Chemo july to dec. Starting chemo again this week- can tocotrienals help?

Mom=cancer mets in lungs and liver. Prim tumor squamous cell in sm bowel. Chemo july to dec. Starting chemo again this week- can tocotrienals help?

Tocotrienols and CA: Tocotrienols are vitamin-e related chemicals called tocopherols and, as such, are powerful antioxidants which are known to have a wide variety of salubrious effects on blood vessel and skin integrity, and have been shown in many studies to have some positive effects on some cancers, although I cannot find any literature related to colon cancer. Check with her md about taking these with her meds. ...Read more

8

8
I keep hearing nightmares about whrt got small cell lung cancer that can go to the brain mine already is in my brain I hav 10 tumors is whrt bad?

I keep hearing nightmares about whrt got small cell lung cancer that can go to the brain mine already is in my brain I hav 10 tumors is whrt bad?

Serious, treatable: Someone with this problem (small cell cancer that has spread to the brain) is facing a very very difficult and serious health issue. It really needs to be discussed with ones doctor. This can be treated, but the details of the expected outcomes and things like that really need to be talked over with one's personal doctor. Every situation is a little different. ...Read more

9

9
Should I take a full strength of chemo. When only 1/3 of the strength causes bad chest pain I have only about 15% of my heart and 20% of my kidney. I have lung cancer, the no cell cancer, with each treatment it has affected my heart. But if I don't take t

Should I take a full strength of chemo. When only 1/3 of the strength causes bad chest pain I have only about 15% of my heart and 20% of my kidney. I have lung cancer, the no cell cancer, with each treatment it has affected my heart. But if I don't take t

It's a choice: Nobody can make this decision for you. It is important that you have an honest and open discussion with your cancer team. You will need to ask what are the reasonable expectations from treatment vs non-treatment? Ultimately, the question only you can answer, after thorough discussion with your team, "will treatment be worse then cancer? What quality of life can I expect after treatment? ". ...Read more

11

11
Is poorly differentiated squamous cell carcinoma something that can be cured?

Is poorly differentiated squamous cell carcinoma something that can be cured?

Yes: Squamous cell Ca is a malignancy of tissues arising cutaneously (skin) and abutting internal structures such as bronchus and vagina/ cervix. High grade malignancies arising from such structures such as Ca of skin, bronchogenic Ca and cervix cancer can be cured iif not in metastatic phase, by wide resection, followed by RT - chemo when needed ...Read more

12

12
My uncle (65 yrs) has focus of poorly differentiated squamous cell carcinoma at the base of the tongue. What does this mean?

My uncle (65 yrs) has focus of poorly differentiated squamous cell carcinoma at the base of the tongue. What does this mean?

Cancer: I'm sorry to hear about your uncle. Squamous cell carcinoma is a type of cancer that affects the head and neck. Risk factors for this cancer at the tongue base (the very back of your tongue) are tobacco, alcohol, and a virus called HPV. He should be seen by a head and neck surgeon to get further workup. The treatment depends on several factors such as the stage. ...Read more

14

14
What is meant by "poorly differentiated" squamous cell carcinoma? Does that mean that it is at the initial stage?

What is meant by "poorly differentiated" squamous cell carcinoma? Does that mean that it is at the initial stage?

Pathologists use: Descriptive terms, now being replaced by molecular markers... Poorly differentiated signified more deranged cellular findings, and conveyed an indication of a higher malignant potential...Not verified, but worse than well-differentiated or moderately differentiated. ...Read more

15

15
What do you suggest if my uncle of age 65 yrs has focus of poorly differentiated squamous cell carcinoma at the base of the tongue he?

What do you suggest if my uncle of age 65 yrs has focus of poorly differentiated squamous cell carcinoma at the base of the tongue he?

Resection: Most squamous Ca's of the tongue are on the lateral anterior 2/3 of tongue. If in the posterior tongue, the approach is by transhyoid pharyngotomy followed by RT and chemo if tumor large. This is especially true if bilateral cervical nodal disease is present. ...Read more

18

18
My husband was diagnosed with stage 2b non small cell lung cancer, had 2 lobes remov ed from right lung almost 2 months ago. Chemotherapy starts?

My husband was diagnosed with stage 2b non small cell lung cancer, had 2 lobes remov ed from right lung almost 2 months ago. Chemotherapy starts?

Depends: The need for further therapy is dictated by many factors. And it may be that your doctors feel no further chemotherapy is needed now. So it is best to ask the doctors what the next plan or stage of action is and go from there ...Read more

19

19
I now have non small cell lung cancer as does my S.O. He also now has MRSA in his lungs and is in the hospital. Do I need to be concerned about myself having it?

I now have non small cell lung cancer as does my S.O. He also now has MRSA in his lungs and is in the hospital. Do I need to be concerned about myself having it?

In the absence of: An active infection in you there is not much you could do about it except maintain strict isolation precautions as is probably enforced in the hospital. Odds are you are already colonized and in equilibrium with the organism for now. Antibiotic therapy is not indicated for you in the absence of an active infection. ...Read more

20

20
What can you do to treat small cell lung cancer?

What can you do to treat small cell lung cancer?

Non surgical: Once cell type determined, surgery is not usual.
Chemo/ radiation as to location etc. ...Read more

21

21
How likely is it that small cell lung cancer will return?

How likely is it that small cell lung cancer will return?

Quite likely: Quite likely, unfortunately. Small cell lung cancer is considered spread at the time of diagnosis, that is why surgery is usually not an option. Some patients may have a complete remission with treatment, but in most cases it returns. ...Read more

22

22
What happens during the last few weeks of small cell lung cancer?

What happens during the last few weeks of small cell lung cancer?

End of life: If small cell carcinoma is terminal, it means that all means of treatment have failed. Symptoms, including shortness of breath, fatigue, and pain will become more pronounced. This is the time to have comfort care measures in place to make the end as bearable as possible. Pain control at this point is critical. ...Read more

23

23
What is the best way to take care of small cell carncinoma lung cancer?

What is the best way to take care of small cell carncinoma lung cancer?

Chemo: If you mean how to best treat small cell lung cancer, depends on the stage. Most patients will get either chemo with chest radiation (limited) or chemo only (advanced). Small cell responds well to chemo as a rule but almost invariably relapses. In rare cases, a patient will have a nodule that after surgery is found to be small cell. Those folks will probably do the best if treated aggressively. ...Read more

24

24
If you get non-small cell lung cancer, how do you feel?

It depends;: Unfortunately lung cancer is usually diagnosed in more advanced stages because it can be silent. Depending on the region it involves, symptoms could varry from cough, weight loss, shortness of breath, coughing up blood, affecting voice quality. If cancer is found incidentally in early stages (patient not symptomatic and cancer found incidentally), the cure rate can be excellent. ...Read more

25

25
What is the best way to treat non small cell lung cancer?

Stage is key: The stage or amount of cancer present helps determine if surgery, or other treatments are the best first step. The early stages are best treated with surgery. Sometimes chemotherapy and radiation are used.
There is no single way to say what is the best treatment. ...Read more

26

26
Is non-small cell lung cancer often a non-smokers cancer?

Is non-small cell lung cancer often a non-smokers cancer?

Yes: There are several types of non-small cell lung cancer. Typically squamous cell is associated with smoking. Adenocarcinoma isn't usually related to smoking. ...Read more

27

27
What are the symptoms associated of non-small cell lung cancer?

What are the symptoms associated of non-small cell lung cancer?

Depends: That depends on where the tumor is: if it is spread to a vital organ, it will causes symptoms there, such as a headache if it is in the brain. If the tumor presses on the airway, it can block that part of the lung and cause pneumonia. If it blocks a blood vessel, it can cause problems with blood flow, etc. So, it depends on where it is. ...Read more

28

28
If I develop non-small cell lung cancer, how will it be treated?

Depends on the stage: Once diagnosed you will need to be staged to evaluate for resection. In general patients with early stage lung cancer (i or ii), who are healthy enough, should be treated with surgery to remove the cancer. In the more advanced stages (iii or iv), surgery by itself is usually not curative, and other treatments like chemotherapy and radiation therapy are required. ...Read more

29

29
What is the survival rate for someone with small cell lung cancer?

What is the survival rate for someone with small cell lung cancer?

Very rare: Of all the people diagnosed with small cell lung cancer, around 1 in 3 have limited disease at the time of diagnosis. With treatment about 25 out of every 100 people (25%) will live for at least 2 years. ...Read more

30

30
What is the life expectancy of someone with small cell lung cancer?

What is the life expectancy of someone with small cell lung cancer?

Short: With limited stage disease the median survival is less than 2 years and with extensive disease less than a year. Having said that there are 5 year survivors. ...Read more

31

31
What is the definition or description of: Non small cell lung cancer?

What is the definition or description of: Non small cell lung cancer?

Non Small Cell Lung: Cancer= the most common category of lung cancer, a descriptive term encompassing a group of lung cancers that behave similarly, literally any epithelial lung cancer that is not histologically a small cell cancer ...Read more

32

32
What should I know about nsclc (non small cell lung cancer)?

Smoking: It is frequently caused by smoking. There is too much to discuss in 400 words! Try this:

http://www.Cancer.Gov/cancertopics/pdq/treatment/non-small-cell-lung/patient/page1. ...Read more

33

33
Are "A549" lung cancer cells a particular type or sub-type of lung cancer, or is this a generic code for lung cancer cells of all types?

Are "A549" lung cancer cells a particular type or sub-type of lung cancer, or is this a generic code for lung cancer cells of all types?

Research cell line: A549 cells are human lung adenocarcinoma cells. The A549 cell line was developed in 1972 through the culturing of cancerous lung tissue. They are responsible for the diffusion of substances, such as water and electrolytes, across the alveoli of lungs. In addition these cells are able to synthesize lecithin and contain high level of unsaturated fatty acids. The A549 cell line is widely used as an in vitro model for drug metabolism and as a transfection host. ...Read more

34

34
How does non small cell carcinoma lung cancer get treated?

Multiple ways: Non-small cell cancers are a heterogenous group, with the two common types being squamous cell and adeno carcinomas. These are usually treated, depending on the stage and type, with surgery, radiation and chemotherapy. ...Read more

35

35
How can non small cell carcinoma lung cancer get created?

How can non small cell carcinoma lung cancer get created?

Non small cell lung: If possible, surgical resection is the first choice. This depends on how widely spread, ir at all, the cancer is. Second choices in therapy include radiation, chemotherapy, or cyber knife. ...Read more

36

36
Does Ayurvedic medicine helps in Small cell lung cancer.??

Does Ayurvedic medicine helps in Small cell lung cancer.??

Adjunct only: Small cell carcinoma is rapidly lethal if untreated by often stays away for a long time with even mild chemotherapy. There are even talks of cures. The ayurvedic medicines or the relationship with the practitioner may be the magic that makes you more comfortable, but it won't touch the cancer itself. ...Read more

37

37
Is their any effective treatment for non small cell lung cancer?

Is their any effective treatment for non small cell lung cancer?

Yes: Usually surgery but can also include chemotherapy and radiation therapy or various combinations of the three depending on stage of disease and various patient factors. ...Read more

38

38
Do you know anyone taking carboplatin for non-small cell lung cancer?

Yes: Carboplatin is a very commonly used medication in this malignancy. Tolerence today is quite good, with the most important side effects being temporarily low blood counts, fatigue, numbness and nausea. A unique point about this agent is that it is dosed based on the patients kidney function, rather than the patients size like most anticancer medications. ...Read more

39

39
Does small cell lung cancer go anywhere in the body or just the brain?

Does small cell lung cancer go anywhere in the body or just the brain?

Can go anywhere: Sclc is particularly notorious for spreading quickly and widely. The brain is one common place for sclc to spread, but it can spread almost anywhere in the body. The liver, bone, adrenal glands, and brain are the most common sites. ...Read more

40

40
What do you suggest if my dad has stage 4 non small cell lung cancer.?

What do you suggest if my dad has stage 4 non small cell lung cancer.?

A cancer center.: Stage 4 lung cancer normally requires chemotherapy and radiation treatment. Hopefully, your fathers case would be reviewed by a tumor conference, with recommendations from specialist in both oncology and radiation. Five year survival rates are usually not over 30%. ...Read more

Lung (Definition)

Deoxygenated blood enters the lungs from the right side of the heart and travels to the lungs. When you inspire, oxygen flows into the lungs, transverses the capilliares and attaches to hemoglobin down a gradient. At the same time, co2 diffuses into the capilaries and is expelled with exhalation. Oxygen rich blood then flows to the left side of the heart and into the ...Read more


Differentiated (Definition)

The process by which cells become progressively more specialized; a normal process through which cells mature. This process of specialization for the cell comes at the expense of its breadth of potential. Stem cells can, for example, differentiate into secretory ...Read more