Top
10
Doctor insights on: Poorly Differentiated Squamous Cell Carcinoma Of The Lung

Share
1

1
How responsive is squamous cell carcinoma of the lung to standard chemotherapy regimens?

How responsive is squamous cell carcinoma of the lung to standard chemotherapy regimens?

Partially: There are several ways of treating scc of the lung. Specifically, there are molecular markers, such as egfr or alk-1 that can be tested to see if you are able to be managed with targeted drug therapy. Radiation is employed more frequently for scc than chemotherapy. All non-small cell cancers of the lung are treated differently than small cell carcinoma, which is much more chemo-sensitive. ...Read more

See 1 more doctor answer
Dr. Barry Rosen
4,224 doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


3

3
What do you suggest if my uncle of age 65 yrs has focus of poorly differentiated squamous cell carcinoma at the base of the tongue he?

What do you suggest if my uncle of age 65 yrs has focus of poorly differentiated squamous cell carcinoma at the base of the tongue he?

Resection: Most squamous Ca's of the tongue are on the lateral anterior 2/3 of tongue. If in the posterior tongue, the approach is by transhyoid pharyngotomy followed by RT and chemo if tumor large. This is especially true if bilateral cervical nodal disease is present. ...Read more

5

5
My uncle (65 yrs) has focus of poorly differentiated squamous cell carcinoma at the base of the tongue. What does this mean?

My uncle (65 yrs) has focus of poorly differentiated squamous cell carcinoma at the base of the tongue. What does this mean?

Cancer: I'm sorry to hear about your uncle. Squamous cell carcinoma is a type of cancer that affects the head and neck. Risk factors for this cancer at the tongue base (the very back of your tongue) are tobacco, alcohol, and a virus called HPV. He should be seen by a head and neck surgeon to get further workup. The treatment depends on several factors such as the stage. ...Read more

7

7
What is meant by "poorly differentiated" squamous cell carcinoma? Does that mean that it is at the initial stage?

What is meant by "poorly differentiated" squamous cell carcinoma? Does that mean that it is at the initial stage?

Pathologists use: Descriptive terms, now being replaced by molecular markers... Poorly differentiated signified more deranged cellular findings, and conveyed an indication of a higher malignant potential...Not verified, but worse than well-differentiated or moderately differentiated. ...Read more

8

8
What is poorly differentiated squamous cell cancer?

What is poorly differentiated squamous cell cancer?

Very malignnt.: This is a kind of squamous cancer that is poorly organized, or has no resemblance to what squamous lining should look like. It follows that this is a very serious cancer that must be treated very aggressively for any chance of a favorable outcome. ...Read more

See 2 more doctor answers
9

9
Can invasive moderately differentiated squamous cell carcinoma of esophagus lead to death?

Can invasive moderately differentiated squamous cell carcinoma of esophagus lead to death?

Depends: This is not as straight forward a question as it seems. If there is surgical removal of the cancer, no metastatic disease and no involved lymph nodes then there may be a surgical cure. If there is extensive disease other treatment s can sometimes be used such as radiation or chemotherapy in addition to surgery with varying success. ...Read more

10

10
Invasive moderately differentiated squamous cell carcinoma.. What does this mean? Severe squamous dysphasia meaning also please.

Degree of dysplasia: Squamous cell carcinomas (scc) are categorized in well-, moderately-, and poorly- differentiated tumors based on histological criteria such as keratin production, cohesion of tumor cells, and nuclear and cellular dysplasia. Severe squamous dysplasia means in the context of invading scc that there was also scc-in situ, which is basically scc just before it invaded. ...Read more

See 1 more doctor answer

Lung (Definition)

Deoxygenated blood enters the lungs from the right side of the heart and travels to the lungs. When you inspire, oxygen flows into the lungs, transverses the capilliares and attaches to hemoglobin down a gradient. At the same time, co2 diffuses into the capilaries and is expelled with exhalation. Oxygen rich blood then flows to the left side of the heart and into the ...Read more


Differentiated (Definition)

The process by which cells become progressively more specialized; a normal process through which cells mature. This process of specialization for the cell comes at the expense of its breadth of potential. Stem cells can, for example, differentiate into secretory ...Read more