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Doctor insights on: Polyposis Colon Cancer

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What is hereditary non-polyposis colorectal cancer (hnpcc) vs familial adenomatous polyposis (fap)?

What is hereditary non-polyposis colorectal cancer (hnpcc) vs familial adenomatous polyposis (fap)?

Both inherited: In fap presents as colonic polyps ( gardners syn will have other tumors ) , autosomal recessive due to mutations in gate keeper, tumor suppres gene. On the contrary hnpcc or lynch syndrome. Is autosomal dominant, due to dna mismatch in repair, associated with other cancers of stomach, endomet. Ca, ovary, brain, skin etc. ...Read more

Dr. Barry Rosen
4,369 doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


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Is colon cancer genetic?

Is colon cancer genetic?

Sometimes: Some colon cancers are related to specific genetic mutations but the majority are not. ...Read more

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Colon cancer chemo necessary?

Colon cancer chemo necessary?

Depends on stage: Chemotherapy is never used for stage 1 cancers (early). It is sometimes used in stage 2 cancers (early but more advanced than stage 1). Chemotherapy is definitely beneficial in stage 3 cancers (locally advanced) and in stage 4 cancers (distant spread). ...Read more

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Colorectal cancer causes?

Colorectal cancer causes?

Heredity & diet: The cause is not known in most cases. In a small number the cause is clearly heredity, e.g., apc and hnpcc. In the garden variety colon cancer, a diet low in fiber and rich in fats may increase the risk of cancer. ...Read more

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Why is the colon prone to cancer in hnpcc (hereditary nonpolyposis colorectal cancer)?

Why is the colon prone to cancer in hnpcc (hereditary nonpolyposis colorectal cancer)?

Genetic mutations: HNPCC or hereditary nonpolyposis colorectal cancer is an autosomal dominant genetic condition that has a high risk of colon cancer The disease first described by Lynch and is associated with other cancers including endometrial ovary and stomach. The increased risk is due to inherited mutations that impair DNA mismatch repair. .Individuals with HNPCC have an 80% lifetime risk for colon ca. ...Read more

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Is colon cancer curable?

Yes: Yes. Many people are cured with colon cancer. If found early surgery alone may be curable. If more advanced (eg, lymph node involvement or metastatic = spread to areas outside of colon), then chemotherapy may be needed. While less likely, even a few % of people with metastatic colon ca may be cured. ...Read more

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Large intestinal cancer. Is that colon cancer?

Large intestinal cancer. Is that colon cancer?

Yes: The large intestine and the colon are words to describe the same anatomic structure in the abdomen. ...Read more

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Is metastatic colon cancer curable?

Is metastatic colon cancer curable?

Possible: But less than 20% survive 5 years. Depends on where the metastases are and how numerous and size. Solitary liver mets without evidence elsewhere in the body can be cured with a liver resection. Diffuse mets to numerous body parts rarelyare curable. ...Read more

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Are colon polyps cancerous?

Are colon polyps cancerous?

Some: There are different types of colon polyps. Some will not turn into cancer. But many (adenomatous polyps in particular) have a high likelihood of turning into cancer if not removed. We think that most colon cancers start as polyps. That is why we recommend colonoscopy at age 50. If you have a precancerous polyp, it can be removed before you get cancer. ...Read more

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Is colon cancer preventable?

For the most part.: Early detection via colonosocpy, not ignoring symptoms such as bleeding, change in bowels, anemia, unintentional weight loss, and not assuming all rectal bleeding is from hemorrhoids are some ways to reduce your chances and maybe prevent colon cancer from developing. ...Read more

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Are breast cancer and colon cancer linked?

Are breast cancer and colon cancer linked?

Not directly usually: There is debate about how closely these 2 cancers are related. Both have hereditary natures and are more common generally in obese patients. Both often begin with more benign precursor lesions like dcis for breast cancer and benign polyps for colon cancer. Both are very common but there is little evidence that having either predisposes to having the other. ...Read more

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Is colon cancer fast-growing?

Is colon cancer fast-growing?

Can be: The fastest-growers are the ones that follow genetic pathways associated with the lynch loci. They may not even be preceded by a polyp -- colonoscopy can be clean one year, and a year later, there's a cancer. That's actually quite fast as cancers go. Hope this helps. ...Read more

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Is bowel cancer hereditary?

Is bowel cancer hereditary?

Somehow yes: There is some genetic predisposition in families with hx. Of colorectal cancer. Diet also plays a rol ( low fiber diet increases cancer). Familiar poliposis increases chances of colon cancer. Colon polyps may degenerate in cancer. Small intestine cancers are rare and difficult to find. In general there are families affected by cancers and families affected by atherosclerosis but both together too. ...Read more

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Is rectal cancer hereditary?

Is rectal cancer hereditary?

Usually not : Most patients with rectal cancer have not inherited it. A small subset have genetic mutations that put them at risk. Probably around 5 % of rectal cancers are hereditary. ...Read more

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Dr. Mark Pack Dr. Pack
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Is colon cancer fatal?

Dr. Mark Pack Dr. Pack
3 doctors agreed:
Is colon cancer fatal?

Not Necessarily: It depends on the stage at diagnosis and the treatment obtained. ...Read more

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Does colonoscopy prevent colon cancer?

Does colonoscopy prevent colon cancer?

Likely: Cancers start as polyps. Removing polyps decreases cancer risk, but no test guarantees finding every polyp. ...Read more

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Does breast cancer increase colon cancer risk?

Does breast cancer increase colon cancer risk?

Rarely.: Some hereditary mutations may increase the risk of both breast and colon cancer. Nevertheless, the majority of all breast and colon cancers are not hereditary. ...Read more

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Is bowel cancer genetic?

Is bowel cancer genetic?

Sometimes: Some colon cancers are related to inheritable genetic mutations but the majority are not. ...Read more

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Will colonic polyps turn into colon cancer?

Will colonic polyps turn into colon cancer?

It can happen: At the time of detection, most polyps are not cancerous. Hoever, over time polyps can develop pre-cancer changes in the cells which then become early cancer changes and finally fully developed cancer. It is best to strictly follow your gastroenterologists screenig schedules if you already have had polyps and get regular screeinig colonoscopies done. ...Read more

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Colon cancer or colorectal cancer, what's the difference?

Colon cancer or colorectal cancer, what's the difference?

Location: Cancers that arise from the epithelium of the large intestine are similar in most ways whether they are in the colon or rectum. Discussions of "colon cancer" unspecified usually mean "colorectal" unless stated otherwise. Usage, including by me, is often sloppy. ...Read more

Dr. Brad Goldenberg
13 doctors shared insights

Colon (Definition)

The colon is another term for the large intestine. This is the final portion of the digestive system, responsible for absorbing water and storing stool before evacuation. It is divided into sections described as cecum; ascending, transverse, descending and ...Read more


Dr. Mark Ingerman
12 doctors shared insights

Colonic (Definition)

This is a combining term referring to some condition, treatment or disease of the colon. Such as colonic enema, colonic ...Read more