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Doctor insights on: Polymyositis And Dermatomyositis Antibody Panel

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RA factor,ANA positive with polyarthritis ACCP negative and polyclonal hypergammaglobulinaemia. whats the diagnosis?

RA factor,ANA positive with polyarthritis ACCP negative and polyclonal hypergammaglobulinaemia. whats the diagnosis?

Auto immune disorder: The information you provided is not sufficient to provide a specific diagnosis. It suggest an auto-immune inflammatory disorder. All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. ...Read more

Dr. Gerald Byrne
128 doctors shared insights

Polymyositis (Definition)

Polymyositis is inflammation of the muscles. It is considered an autoimmune disease and which ones on inflammatory cells targeted their activity against muscle cells. This may be associated with fatigue and muscle weakness. There are several treatment options routinely use by a rheumatologists. I'm happy to do ...Read more


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What are dermatomyositis, polymyositis and inclusion body myositis?

What are dermatomyositis, polymyositis and inclusion body myositis?

Separate myosotis : Each is a specific type of inflammatory muscle disease. We call this myositis because the muscles can show information. When you have this you need an extensive evaluation looking for other associated issues. Therapy will be different for each of these. ...Read more

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Is positive anticardiolipin and positive antidsdna needed for lupus diagnosis? I have positive Ana, WBC 4.20 skin rashes, plus arthritis in joints

Is positive anticardiolipin and positive antidsdna needed for lupus diagnosis? I have  positive Ana, WBC 4.20 skin rashes, plus arthritis in joints

Rheumatologist: Anticardiolipin antibodies may not be present in many lupus cases but Ana and antidsdna findings are common. Your findings are consistent with lupus, but the rheumatologist is best qualified to evaluate and advise you about diagnosis and treatment. ...Read more

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What would cause a high positive ANA (1:640) speckled, nucleolar with a low positive smooth muscle antibody (1:40) but negative SS-A, SS-B, anti-Smith, RNP, SCL-70, Anti Jo antibodies? Liver disease?

Probably normal: Many people have a positive ANA without being sick. If you also have elevated liver enzymes, a workup for autoimmune hepatitis may be continued, but if there's nothing to suggest a liver problem biochemically, I'd not be in a hurry to diagnose despite anti-smooth-muscle. ANA means nothing apart from the clinical picture. Best wishes. ...Read more

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What are dermatomyositis, polymyositis and inclusion body myositis?

Separate myosotis : Each is a specific type of inflammatory muscle disease. We call this myositis because the muscles can show information. When you have this you need an extensive evaluation looking for other associated issues. Therapy will be different for each of these. ...Read more

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ANA 1:320 Homogenous pattern, positive ssDNA, and chromatin antibodies 60 u/ml. Fatigue and joint pain. Is lupus a possibility?

ANA 1:320 Homogenous pattern, positive ssDNA, and chromatin antibodies 60 u/ml. Fatigue and joint pain. Is lupus a possibility?

Yes: 1:320 along with positive ssDNA Ab and the symptoms you are having makes Systemic Lupus a strong possibility. I suggest seeing a Rheumatologist so they can also evaluate and potentially initiate treatments. ...Read more

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Blood tests showed high antibodies to: ana, ssdna, sm, rnp/sm, ssa(ro), ssb(la), scl-70, centromere. Is this likely lupus or a different automimmune?

Prob false positive: To have all these antibodies to be positive is suggestive of a false positive result. Virus infection can cause similiar findings. Ultimately these results have to be interpretted in the context of your doctor's findings. Talk to your doctor. ...Read more

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Does highly elevated antinuclear antibody result always mean systemic lupus erythematosus?

Not always: Unfortunately, there is no single laboratory test that absolutely rules in or out systemic lupus erythematosis (sle). Although a highly positive antinuclear antigen (ANA) is common in sle, diagnosis is based on a careful history, physical exam and laboratory evaluation. ...Read more

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Antinuclear antibody and anticardiolipin ab both positive, what are implications?

Connective Tissue Dx: With a positive ana, you must now characterize it. The positive anticardiolipin abs need to quatified for the 3 types: igg, igm, and iga. The ones that are likely to cause thrombotic issues are in order: igm, igg, and iga. You need a rheumatologic or immunologic evaluation. ...Read more

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Ana positive strong family history of lupus. Lupus symptoms. Could it be sarcoidosis instead of lupus.

Maybe: ANA positive diseases are related. Diagnosis is based not just on serologic testing, but also on your clinical symptoms. You should be evaluated by a rheumatologist in order to receive an accurate diagnosis and then receive the most appropriate treatment. ...Read more

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Probability for lupus w/ seizures, peeling rash on hands, arthritis, low WBC and rbc, kidney/liver symt, and anticardiolipin antibodies and fam. Hist?

High: The answer lies with the results of the blood tests. If the ANA is positive you have lupus. If the ANA and other autoantibodies are negative then you can still have lupus. Trust your rheumatologist. ...Read more

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Ongoing polymyositis treatment @5mg prednisone&500mg sulfasalazine/day&17.5mg methotrexate/wk...What are appropriate jo1, wbc, abs mono, etc results?

Ongoing polymyositis treatment  @5mg prednisone&500mg sulfasalazine/day&17.5mg methotrexate/wk...What are appropriate jo1, wbc, abs mono, etc results?

Speak to your MD: With all due respect, your best place for this source of information is the physician providing your care, who knows you as a patient, your medical condition, and any other factors that may influence your treatment and results. This type of forum is best suited for general information on a topic, but not advice on specific care of a complicated problem. ...Read more

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Given a positive RNP antibody test, what are the clinical diagnostic criteria for MCTD?

Given a positive RNP antibody test, what are the clinical diagnostic criteria for MCTD?

MCTD: Usually considered diagnostic if high RNP titer, and two or more of the following: Raynauds, myositis, synovitis and swollen fingers/hands. ...Read more

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Ana positive low c3c and 4 no symptoms of auto immune could my fatry liver ve auto immune hepatitis?

Need more info: Your history, symptoms, physical exam and laboratory data are all essential in arriving at a diagnosis, which cannot be done on the internet. Hepatitis is usually manifested in the laboratory by the presence of elevated enzymes which are released from liver tissue. It is possible this represents autoimmune hepatopathy, but need far more data. ...Read more

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Positive diagnosis (scleroderma, polymyositis) with negative blood tests? Is that common?

Positive diagnosis (scleroderma, polymyositis) with negative blood tests?  Is that common?

PM/Scl: The paradox of rheumatologic diseases is that there are more lab tests in this area than any other, and they of relatively less value compared to the history and physical findings than in other fields. If your rheumatologist is comfortable with the diagnosis of "scleromyositis", which usually features anti-pm/scl, i'd accept it even with a single negative result, and proceed. ...Read more

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Can mixed connective tissue disease be diagnosed with a positive ANA and positive rnp anitibodies?

NO.: You must have a compatible clinical picture first and the absence of another diffuse connective tissue disorder which could explain the symptoms and lab findings. A high titer ANA and anti-u1-rnp is a pretty good marker of mctd though. ...Read more

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Does the anti-nuclear ab titer and pattern check for Lyme disease?

Does the anti-nuclear ab titer and pattern check for Lyme disease?

No: Anti-nuclear antibody tests check for autoimmune diseases such as lupus. Some people with longstanding lyme do develop auto-immune disease and might have anti-nuclear antibodies, but most people with lyme do not have anti-nuclear antibodies. ...Read more

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Positif ANA IF, Anti-B2 glicoprotein igM, anti-CMV igG, Lupus Anticoagulants, history of DVT. Dr suspect Antiphospholipid Syndrome (APS). Possible?

Positif ANA IF, Anti-B2 glicoprotein igM, anti-CMV igG, Lupus Anticoagulants, history of DVT. Dr suspect Antiphospholipid Syndrome (APS). Possible?

POSSIBLE: Your lab outcomes plus the prior DVT, seem consistent, but other labs may further assist such as changes in PTT. Might get additional opinion to confirm your diagnosis, and exclude other problems, but certainly antiphospholipid antibody syndrome seems high on list. ...Read more

Antibody (Definition)

An antibody is a protein the body's immune system makes to identify potentially harmful substances in the body. Antibodies attach to the substance on a molecular level and mark it so the immune ...Read more


Dr. Ramachandran Srinivasan
237 doctors shared insights

Dermatomyositis (Definition)

A rare inflammatory disease marked by muscle weakness and ...Read more