Doctor insights on:
Polycythemia Vera Splenomegaly
Sometimes.: Most patients with polycythemia vera develop the condition in adulthood, most commonly from an acquired mutation in the jak2 gene, and are not born with it. However, there are families who pass on the tendency to have a high red blood cell count through a variety of genetic mutations. It is usually well known in the family when that is the case. ...Read more
Polycythemia: Polycythemia rubra vera and polycythemia vera are the same thing - a myeloproliferative disorder which causes production of too many red cells (and usually white cells and platelets also). Polycythemia or erythrocytosis just means someone has too many red cells, whether due to prv, high altitude, sleep apnea, emphysema, certain cancers, or certain congenital abnormalities of red cell production. ...Read more
Polycythemia: Polycythemia is a terminology used for a condition where your hemoglobin is elevated above the normal range.It does not tell you what the cause of the condition- which could be caused by a primary bone marrow problem -( which is called polycythemia rubra vera -abbreviated as polycythemia vera) vs some other secondary conditions such as chronic lung problem, sleep apnea, liver mass/renal mass et. ...Read more
Red blood cells-5.9, hematocrit- 55%, hemaglobin-18.0, esr-2, ldh-199, white blood cells- 9.0 (high neutrophils) & platlets-285, 000 polycythemia vera?
Can't tell. need w/u: Normal range will vary -depending on the range used on each lab. On my lab, hb of 18 is still normal for male. Your white blood cell and platelet are also within normal range. I don't see any problem there-except you said you have high neutrophils- which can be caused by many things. However, if you are worried about p.Vera- go to see a hematologist and she/he will be able to help you. ...Read more
Controversial: There is a risk of transformation to acute leukemia just from having P Vera. But it is very low. Whether hydroxyurea increases that risk has not be definitively answered. Most hematologists find the benefit of controlling the disease greatly outweighs the risk. There is a new drug - Jakafi (ruxolitinib) - just approved for PV if not well controlled or if side effects of HU too great. Talk to your hematologist. ...Read more
No: Pv by itself does'nt cause low grade fevers. However, pv can increase your risk to have blood clots and blood clots can give you low grade fevers also, pv can transform into other condition i.E myelofibrosis as well as mds/ acute leukemia in about 20%-30%). Low grade fevers occur quite commonly in myelofibrosis and acute leukemia. See your md to rule out other condition i.e. Autoimmune , infection. ...Read more
Yes: PRV is hypercoaguable conditionGet a more detailed answer ›
Elevated RBC: Polycythemia refers to abnormally high of hemoglobin/hematocrit or .Rbc. There are many factors that can explain polycythemia-primary bone marrow problem- i.e. Polycythemia vera (pv) -vs. Other condition such as- problems with lung/sleep apnea that can result in decrease o2 level in the body ( hypoxia), other condition is kidney/liver, familial disorder etc. See and discuss further with your md. ...Read more
Your Doctor is guide: P. Vera is a rare condition. It is not difficult to diagnose provided you have consulted a specialist...A hematologist is the right specialist to help you with this issue. It typically manifests with high hemoglobin( >17 grams) and often has high white blood cell count as well as high platelets associated with high hemoglobin levels. ...Read more
To the extent that: P vera would be associated with increased rbc turnover, a modest increase in bili is possible. However, the disease is one of proliferation more than destruction, so if the bili is quite high we need to evaluate. ...Read more
Is there a possible link between hereditary hemochromatosis, polycythemia vera (primary jak2 mutation), & idiopathic pulmonary arterial hypertension?
Indirectly: Because polycythemia Vera results in too many red blood cells being formed, blood flow may stagnate leading to vascular obstructions. If this occurs in the eye, as in a central retinal vein occlusion, the resulting consequence can lead to secondary glaucoma, which is often very difficult to manage. ...Read moreSee 1 more doctor answer
Not that I know of.: The big changes of this are elevated rbc count, hemoglobin, hematocrit, and decreased ESR (erythrocyte sedimentation rate). The elevations come without decrease in volume, and can be up to 70-80% for hematocrit, and 8-9 million rbc count. Changes in RDW may be from so many rbc's in the system, but even if they do occur, do not apparently have effect on prognosis or relevance to the cause of this. ...Read more
How is polycythemia rubra vera differentiated from polycythemia associated with stress? RBC only elevated once in life. HGB/HCT elevated often.
Stress?: Stress doesn't cause polycythemia. Being dehydrated is a common cause. If your Hgb/Hct is only slightly elevated, stop worrying -- reference ranges are set so that several percent of healthy folks fall outside. If it's well above, consider a workup for the causes, including a variant hemoglobin and a subtle right-to-left shunt. ...Read more
No: No. It does not cause peripheral neuropathybut it can cause a condition known as erythromelalgia, which presents with redness and something burning sensation of the hands and feet that simulate neuropathy. This is often relieved with the use of Aspirin once or twice a day (in addition to the usual treatment for the disease itself of indicated). ...Read more
Adult male,bone marrow biopsy show Erythroid hyperplasia
RBC borderline on high side,thrombocytopenia fluctuate,
Splenomegaly,negative for infections.
CBC Results: If you can send us the complete blood count (CBC) report which includes Hb, WBC, Platelet counts done from 2 different dates, we can tell you if there is anything serious or how to manage your concerns. WE need to know the number of platelets(Count). RBC numbers are not useful...instead we use hemoglobin as a better test to reflect any problems with RBCs. ...Read more
What does this mean? "Severe crythroid hyperplasia consistent with hematological diagnosis of polycythemia vera"
Erythroid hyperplasi: Erythroid hyperplasia is an excess of red blood cell precursors in the bone marrow. This is can be due to benign/reactive or neoplastic processes. Polycythemia vera is a primary bone marrow disease in which too many red cells (erythroid cells) are produced due to mutation in a cell line. diagnosis is made on blood findings. This is chronic disease (not same as acute leukemia) but needs treatment ...Read more
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