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Sometimes.: Most patients with polycythemia vera develop the condition in adulthood, most commonly from an acquired mutation in the jak2 gene, and are not born with it. However, there are families who pass on the tendency to have a high red blood cell count through a variety of genetic mutations. It is usually well known in the family when that is the case. ...Read more
Polycythemia: Polycythemia rubra vera and polycythemia vera are the same thing - a myeloproliferative disorder which causes production of too many red cells (and usually white cells and platelets also). Polycythemia or erythrocytosis just means someone has too many red cells, whether due to prv, high altitude, sleep apnea, emphysema, certain cancers, or certain congenital abnormalities of red cell production. ...Read more
Polycythemia: Polycythemia is a terminology used for a condition where your hemoglobin is elevated above the normal range.It does not tell you what the cause of the condition- which could be caused by a primary bone marrow problem -( which is called polycythemia rubra vera -abbreviated as polycythemia vera) vs some other secondary conditions such as chronic lung problem, sleep apnea, liver mass/renal mass et. ...Read more
Your Doctor is guide: P. Vera is a rare condition. It is not difficult to diagnose provided you have consulted a specialist...A hematologist is the right specialist to help you with this issue. It typically manifests with high hemoglobin( >17 grams) and often has high white blood cell count as well as high platelets associated with high hemoglobin levels. ...Read more
Yes: PRV is hypercoaguable conditionGet a more detailed answer ›
Elevated RBC: Polycythemia refers to abnormally high of hemoglobin/hematocrit or .Rbc. There are many factors that can explain polycythemia-primary bone marrow problem- i.e. Polycythemia vera (pv) -vs. Other condition such as- problems with lung/sleep apnea that can result in decrease o2 level in the body ( hypoxia), other condition is kidney/liver, familial disorder etc. See and discuss further with your md. ...Read more
Red blood cells-5.9, hematocrit- 55%, hemaglobin-18.0, esr-2, ldh-199, white blood cells- 9.0 (high neutrophils) & platlets-285, 000 polycythemia vera?
Can't tell. need w/u: Normal range will vary -depending on the range used on each lab. On my lab, hb of 18 is still normal for male. Your white blood cell and platelet are also within normal range. I don't see any problem there-except you said you have high neutrophils- which can be caused by many things. However, if you are worried about p.Vera- go to see a hematologist and she/he will be able to help you. ...Read more
Controversial: There is a risk of transformation to acute leukemia just from having P Vera. But it is very low. Whether hydroxyurea increases that risk has not be definitively answered. Most hematologists find the benefit of controlling the disease greatly outweighs the risk. There is a new drug - Jakafi (ruxolitinib) - just approved for PV if not well controlled or if side effects of HU too great. Talk to your hematologist. ...Read more
No: Alpha and beta thalassemia have not been reported to cause leukemia, which is cancer of the white blood cells. There is a study of beta thal. Major & intermedia patients in iran, where researchers found 5 leukemia cases in about 4, 600 patients. That is a higher rate of leukemia than in the general population there, but details were unavailable as to what other factors were present in the patients. ...Read moreSee 1 more doctor answer
To the extent that: P vera would be associated with increased rbc turnover, a modest increase in bili is possible. However, the disease is one of proliferation more than destruction, so if the bili is quite high we need to evaluate. ...Read more
Is there a possible link between hereditary hemochromatosis, polycythemia vera (primary jak2 mutation), & idiopathic pulmonary arterial hypertension?
NO: The average lifespan for someone with polycythemia is about the same as it is without polycythemia. The risk of complications of the disease can be decreased with treatment, when appropriate. This may include Aspirin to decrease the risk of blood clots, phlebotomy to decrease the red blood cell count, and/or medication to control the blood counts. ...Read more
Not that I know of.: The big changes of this are elevated rbc count, hemoglobin, hematocrit, and decreased ESR (erythrocyte sedimentation rate). The elevations come without decrease in volume, and can be up to 70-80% for hematocrit, and 8-9 million rbc count. Changes in RDW may be from so many rbc's in the system, but even if they do occur, do not apparently have effect on prognosis or relevance to the cause of this. ...Read more
No: No. It does not cause peripheral neuropathybut it can cause a condition known as erythromelalgia, which presents with redness and something burning sensation of the hands and feet that simulate neuropathy. This is often relieved with the use of Aspirin once or twice a day (in addition to the usual treatment for the disease itself of indicated). ...Read more