Doctor insights on:
Polyclonal Increase In Gamma Globulins
Immunifixation identifies m spike as IGg Kappa polyclonal gamma globulin to consist mainly of IGg Kappa n Lamda with fair amounts of Iga means what?
?? Chronic Infection: M spike of polyclonal IgG (kappa & lambda) globulin mostly suggest chronic infectious or inflammatory process & rarely hematologic malignancies. You need a complete work up for ch. liver disease, hepatitis B/C, ch.bacterial, viral & fungal infection, HIV, autoimmune diseases & if negative then evaluate for hematological disorder. CHECK FOR Ch. INFECTION & HEPATITIS. Update me with your result. ...Read more
What does elevated Igg-2364 and gamma globulin 2.2 mean with polyclonal gammopathy and Kappa and lambda typing increased?
Nothing serious: Polyclonal gammopathy does not have the seriousness of monoclonal gammpathy. Firstly your IgG and total globulin levels are only mildly elevated, so It may not mean any disease. One cause is chronic inflammation(infections) such as Chronic arthritis or chronic liver disease, conditions which can be checked out or ruled out easily if you ask your doctor and seek his/her advice about it. ...Read moreSee 1 more doctor answer
Slightly elevated beta fraction from serum protein electrophoresis. Beta 1.07 (high) (0.52-0.98) increased beta fraction, no monoclonal or polyclonal gammopathy seen. Immunofixation normal.
It can: Yes, it can . It will depend on how much is the quantity of the monoclonal proteine, how many plasma cells on the bone marrow and ultimately whether one has end organ damages/ whether some other organs are affected significantly by the monoclonal protein. That is why some blood work, imaging study and bone marrow biopsy need to be done. ...Read more
High KAPPA/LAMBDA LIGHT CHAIN/slightly high ratio.No Monoclonal protein immunofixation or serum electrophoresis. Is this a type of cancer?Normal WBC
Resent blood work states IgM 875, an appearant polyclonal glammopathy IgM, kappa and Lambda light chains appear increased. Possible Multiple myeloma?
No: Myeloma is monoclonal. I trust you do not have urinary light chains. Most polyclonal stuff means nothing. If you are symptomatic, look for another cause of any symptoms. ...Read more
Kappa light chain in upep. Elevated k/l chains in serum but ratio normal. Wbc, rbc in urine with 2g/d protein. More/which workup/specialist needed?
Nephrologist: You need a nephrologist to follow up on those tests, but your doctor or the doctor who ordered those tests can direct you better, wish you wellness ...Read more
Serum -tiny IgM kappa monoclonal protein b2 region, urine - tiny IgM k paraproteinemia in gamma region. Was a mistake made or is lab normal?
Monoclonal: •multiple myeloma (g>a>m>e, d) •primary macroglobulinemia (waldenstrøm’s, igm) •monoclonal gammopathy of undetermined significance (mgus) (converts at 2% per year to myeloma) •miscellaneous conditions •(converts at 2% per year to myeloma) these all have to be thought of by the hematologist. ...Read more
Is a tiny IgM kappa monoclonal protein migrating in beta2 region considered specific for waldenström's macroglobulinemia irrespective of size?
No. MGUS: Mgus = monoclonal gammopathy of unknown significance. Igm is associated more with waldenstrom's macroglobulinemia (vs igg, iga, igd, ige with multiple myeloma). More info on background is here: http://bloodjournal.Hematologylibrary.Org/content/109/12/5096.Full" rel="nofollow" ta. ...Read more
Is elevated kappa/lambda ratio on serum FLC test inherently monoclonal, even if neither kappa or lambda is elevated? Ratio high b/c lambda is low, not because of high kappa. SPEP/UPEP & IFE normal. High IgA, low IgG. Clean marrow biopsy. Polyclonal?
Clinical context : The use of light chains is limited in diseases other than monoclonal gammopathies, such as myeloma or amyloidosis. If this is the context that yours got checked the results do not suggest such a condition. With no gammopathy suggested by results the question regarding clonality has no grounds. As any other test, trending the results would help in integrating it in a meaningful clinical context. ...Read moreSee 1 more doctor answer
See a specialist: You don't tell me how you were found to have that high level. If you have no symptoms to go with that finding and other laboratory blood tests are normal, you probably have what is called monoclonal gammopathy. If you have symptoms or tests are affected, there are several possible diagnosis. For proper evaluation, see an immunologist or hematologist. ...Read more
Need more info: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, What is total gamma globulin level? If it is more than 2.0 gm/dL it needs to be evaluated. There are many causes of polyclonal gammopathy., and some of those are serious. ...Read moreSee 1 more doctor answer
Adnorm. Blood & cfs results: high: CSF protein-47, high cfs albumin-30.9; low total protein-5.7, low gamma globulin-.5, low IgG quantitative -621 worry?
CSF: Some experts consider CSF protein levels to be normal if the value is equal to or below your age in years. I don't think in your case there is a reason to worry. Other CSF components are important as well. Check with your physician to see if there is any reasons to worry. Hope you feel well soon. ...Read more
Depends: If you have M protein from another class of immunoglobulin, then the cells producing this M protein would crowd out the other immunoglobulin producing cells in the bone marrow leading to a lower level of what that cell would ordinarily produce. Some Multiple myeloma cases are of no medical significance but needs to be followed. Many myeloma patients are prone to bacterial infections. ...Read more
Blood flow cytmtry shows dual positive cd4cd30 cells absolute count of 2354. IGG slightly elevated with elevated light chains, T cell Beta clone noted?
Asking what?: If your are requesting a diagnosis online, this is not the appropriate venue. Though the flow cytometry results are not totally normal, your results should be reviewed with the physician who ordered it. This format does not give us the ability to determine if your clinical presentation and lab results are consistent with a specific diagnosis. ...Read more
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