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Doctor insights on: Polyclonal Gammopathy Symptoms

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What is mild polyclonal gammopathy that's what the dr said I have but I haven't seen him yet?

What is mild polyclonal gammopathy that's what the dr said I have but I haven't seen him yet?

Means little alone: You have more antibodies on board than most people. Maybe you're just getting over an illness, or it's your celiac disease, or it's just you. This is meaningful only as part of a workup for other illness. ...Read more

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Dr. Buck Parker
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Dr. Warren Foster
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Gammopathy (Definition)

A gammopathy is an abnormal gammaglobulin or gammaglobulin level. A monoclonal gammopathy is a single abnormal protein that can indicate a bone marrow cancer called multiple myeloma, or a lymphoma. Further evaluation is required to determine if a monoclonal gammopathy ...Read more


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I was diagnosed with RA a couple years ago. Just did ife and pe serum and it is suggested an apparent polyclonal gammopathy. What is that?

I was diagnosed with RA a couple years ago. Just did ife and pe serum and it is suggested an apparent polyclonal gammopathy. What is that?

Active immune system: The part of blood that contains antibodies is gamma globulin. Polyclonal refers to the fact that many different antibodies are present. The increase in quantity reflects a broadly activated immune system cranking out lots of antibodies. This is common in autoimmune disease and is not a concern. ...Read more

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Dr. Buck Parker
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What does elevated Igg-2364 and gamma globulin 2.2 mean with polyclonal gammopathy and Kappa and lambda typing increased?

Need more info: What is your medical condition? Per se, polyclonal increases in IgG does not mean much although it may indicate the presence of a chronic infection if there is sign of infection. ...Read more

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Can you explain what this might mean: "apparent polyclonal gammopathy: igm. Kappa and lambda increased". Immunoglobulin m is also high at 437.?

Can you explain what this might mean: "apparent polyclonal gammopathy: igm.  Kappa and lambda increased".  Immunoglobulin m is also high at 437.?

Monoclonal processes: Are often malignant or pre malignant. Polyclonal processes are usually reactive/infectious/inflammatory. ...Read more

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What would cause constant recurring goosebumps in left leg for no reason?. Have neuropathy as well. Normal brain MRI but have polyclonal gammopathy.

What would cause constant recurring goosebumps in left leg for no reason?. Have neuropathy as well. Normal brain MRI but have polyclonal gammopathy.

Neuropathy: Goosebumps are caused by stimulation of the autonomic system - which innervate the small muscles attached to each hair. Anything that causes an adrenaline rush or other activation of your sympathetic nerves (such as fear, or cold) will cause goose bumps (also known as "pilo erection"). It's also possible this is caused by a condition called autonomic hyperreflexia. Talk with your neurologist. ...Read more

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Dr. Buck Parker
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How does having polyclonal gammopathy correlate with lupus- I have lupus and polyclonal gammopathy does having this mean you have a more severe form of lupus, they did an spep be4 lupus and i had that?

How does having polyclonal gammopathy correlate with lupus- I have lupus and polyclonal gammopathy does having this mean you have a more severe form of lupus, they did an spep be4 lupus and i had that?

Polyclonal gamma pat: Polyclonal gammoparhy is seen frequently in chronic inflammation/ autoimmune disorder etc. Lupus is certainly one of the condition that causes/ associated with polyclonal gammopathy . The presence of polyclonal gammopathy does not tell you whether the lupus will be more severe or less severe . Discuss with your rheumatologist further. ...Read more

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Been diagnosed with peripheral neuropathy blood test showed high immunoglobulin m w/polyclonal gammopathy. Kappa/lambda increase. Possible meaning?

Been diagnosed with peripheral neuropathy   blood test showed high immunoglobulin m w/polyclonal gammopathy. Kappa/lambda increase. Possible meaning?

PlasmaCellDIsorder: May have plasma cell disorder/multiple myeloma. Plasma cells are a type of white blood cells that produces immunoglobulin(antibodies). Multiple myeloma is a cancerous or excessive proliferation of these plasma cells which may lead to excessive high levels of calcium/bone pain/renal failure/anemia (low blood counts). Need to see hematologist (blood doctor specialist). ...Read more

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What is the definition or description of: gammopathy?

What is the definition or description of: gammopathy?

See below: A gammopathy is an abnormal gammaglobulin or gammaglobulin level. A monoclonal gammopathy is a single abnormal protein that can indicate a bone marrow cancer called multiple myeloma, or a lymphoma. Further evaluation is required to determine if a monoclonal gammopathy represents a serious disease. ...Read more

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