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Doctor insights on: Polyclonal Gammopathy Symptoms

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What is mild polyclonal gammopathy that's what the dr said I have but I haven't seen him yet?

What is mild polyclonal gammopathy that's what the dr said I have but I haven't seen him yet?

Means little alone: You have more antibodies on board than most people. Maybe you're just getting over an illness, or it's your celiac disease, or it's just you. This is meaningful only as part of a workup for other illness.

Dr. James Lin
31 Doctors shared insights

Gammopathy (Definition)

A gammopathy is an abnormal gammaglobulin or gammaglobulin level. A monoclonal gammopathy is a single abnormal protein that can indicate a bone marrow cancer called multiple myeloma, or a lymphoma. Further evaluation is required to determine if a monoclonal gammopathy ...Read more


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I have for 3 years high rcp and esr and polyclonal gammopathy. Why? Should I investigate with my family Dr?

I have for 3 years high rcp and esr and polyclonal gammopathy. Why? Should I investigate with my family Dr?

Yes: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, All of the test results suggest chronic inflammation and it should be investigated.

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I was diagnosed with RA a couple years ago. Just did ife and pe serum and it is suggested an apparent polyclonal gammopathy. What is that?

I was diagnosed with RA a couple years ago. Just did ife and pe serum and it is suggested an apparent polyclonal gammopathy. What is that?

Active immune system: The part of blood that contains antibodies is gamma globulin. Polyclonal refers to the fact that many different antibodies are present. The increase in quantity reflects a broadly activated immune system cranking out lots of antibodies. This is common in autoimmune disease and is not a concern.

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How does having polyclonal gammopathy correlate with lupus- I have lupus and polyclonal gammopathy does having this mean you have a more severe form of lupus, they did an spep be4 lupus and I had that?

Polyclonal gamma pat: Polyclonal gammoparhy is seen frequently in chronic inflammation/ autoimmune disorder etc. Lupus is certainly one of the condition that causes/ associated with polyclonal gammopathy. The presence of polyclonal gammopathy does not tell you whether the lupus will be more severe or less severe. Discuss with your rheumatologist further.

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In protein's electrophoresis Is polyclonal gammopathy alway pathological? Thanks

Need more info: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, What is total gamma globulin level? If it is more than 2.0 gm/dL it needs to be evaluated. There are many causes of polyclonal gammopathy., and some of those are serious.

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What does elevated Igg-2364 and gamma globulin 2.2 mean with polyclonal gammopathy and Kappa and lambda typing increased?

Nothing serious: Polyclonal gammopathy does not have the seriousness of monoclonal gammpathy. Firstly your IgG and total globulin levels are only mildly elevated, so It may not mean any disease. One cause is chronic inflammation (infections) such as Chronic arthritis or chronic liver disease, conditions which can be checked out or ruled out easily if you ask your doctor and seek his/her advice about it.

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Can you explain what this might mean: "apparent polyclonal gammopathy: igm. Kappa and lambda increased". Immunoglobulin m is also high at 437.?

Can you explain what this might mean: "apparent polyclonal gammopathy: igm. Kappa and lambda increased". Immunoglobulin m is also high at 437.?

Monoclonal processes: Are often malignant or pre malignant. Polyclonal processes are usually reactive/infectious/inflammatory.

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What is a polyclonal gammopathy? Dr did protein serum test, a2, beta, gamma and crp is high. High wbc anc is also high, with tear drop cells 25%

What is a polyclonal gammopathy? Dr did protein serum test, a2, beta, gamma and crp is high. High wbc anc is also high, with tear drop cells 25%

Go to your doctor: You need to have a hematologist review the results. If your doctor ordered these tests, they should review the results with you.

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What would cause constant recurring goosebumps in left leg for no reason? . Have neuropathy as well. Normal brain MRI but have polyclonal gammopathy.

What would cause constant recurring goosebumps in left leg for no reason? . Have neuropathy as well. Normal brain MRI but have polyclonal gammopathy.

Neuropathy: Goosebumps are caused by stimulation of the autonomic system - which innervate the small muscles attached to each hair. Anything that causes an adrenaline rush or other activation of your sympathetic nerves (such as fear, or cold) will cause goose bumps (also known as "pilo erection"). It's also possible this is caused by a condition called autonomic hyperreflexia. Talk with your neurologist.

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Been diagnosed with peripheral neuropathy blood test showed high immunoglobulin m w/polyclonal gammopathy. Kappa/lambda increase. Possible meaning?

Been diagnosed with peripheral neuropathy blood test showed high immunoglobulin m w/polyclonal gammopathy. Kappa/lambda increase. Possible meaning?

PlasmaCellDIsorder: May have plasma cell disorder/multiple myeloma. Plasma cells are a type of white blood cells that produces immunoglobulin (antibodies). Multiple myeloma is a cancerous or excessive proliferation of these plasma cells which may lead to excessive high levels of calcium/bone pain/renal failure/anemia (low blood counts). Need to see hematologist (blood doctor specialist).

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What is the definition or description of: gammopathy?

What is the definition or description of: gammopathy?

See below: A gammopathy is an abnormal gammaglobulin or gammaglobulin level. A monoclonal gammopathy is a single abnormal protein that can indicate a bone marrow cancer called multiple myeloma, or a lymphoma. Further evaluation is required to determine if a monoclonal gammopathy represents a serious disease.

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What is monoclonal gammopathy?

A tumor type: There are various grades of monoclonal gammopathy. The three types, in increasing order of malignancy are monoclonal gammapathy of undetermined significance (MGUS), smoldering myeloma and the last one, which is a cancer, multiple myeloma.

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What is gammopathy?

What is gammopathy?

Immoglobulin finding: If a person has an unusually large number of antibodies, but not a single one in great excess, we speak of a polyclonal gammopathy; it's never a specific finding. An abundance of a single antibody is a monoclonal antibody "spike" that is quite common but may indicate or precede (often by decades) plasma cell "multiple" myeloma.

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What are the tests for gammopathy?

What are the tests for gammopathy?

Blood urine and bone: Blood tests. A serum protein electrophoresis. Urine tests. Urine tests may be performed to determine if the abnormal protein is being released in the urine or to diagnose any kidney damage as a result of the protein. Bone marrow tests. A bone marrow biopsy may be completed to determine the severity of the problem.

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What is monoclonal gammopathy about?

MonoclonalGammopathy: Is paraproteinemia associated with multiple myeloma. The most important fact that it is not cancer.

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What can cause monoclonal gammopathy?

What can cause monoclonal gammopathy?

Mayo Clinic say: Plasma cells are a type of white blood cell. They are found in your bone marrow. Plasma cells produce some of the antibodies that help your body fight infection. Monoclonal gammopathy of undetermined significance occurs when plasma cells in your bone marrow produce an abnormal protein called monoclonal protein (m protein).

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What is the treatment for gammopathy?

What is the treatment for gammopathy?

Monoclonal gammopath: According to mayo clinic were the diease was discovered. No treatment is required for people diagnosed with monoclonal gammopathy of undetermined significance (mgus). About 20 percent of people with mgus develop a more serious condition, such as multiple myeloma or other cancers or blood disorders. Therefore, careful observation and follow-up are important.

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What's monoclonal gammopathy of undetermined significance?

MGUS: Is a common precancerous condition affecting people 50 years of age and older. It was first described by mayo clinic researchers in 1978 and is characterized by the presence of an abnormal protein in the blood called a (monoclonal) protein or m protein. Mgus has a small risk (1 percent each year) of progressing to a blood cancer called multiple myeloma or a related condition.