Doctor insights on:
Pneumococcal Antibody Deficiency
Is IVIG given for pneumococcal antibody deficiency. What cause pneumococcal deficiency? What's the usual treatment?
More Complicated: IVIG or subcutaneous forms are given for immune deficiencies. There is a type of immune deficiency called common variable immune deficiency which usually results in low IgG antibody and impaired response to pneumococcal vaccination of infection. If you are worried about this, you should see an immunologist for further evaluation. ...Read more
Maybe none: We need a lot more information. The positive ANA may not indicate anything. Just because there is a positive ANA does not mean you have lupus. The low IgA and low pneumococcal antibodies may not cause any symptoms. Your evaluation should include pneumococcal antigen stimulation to see if you are responsive. You need further evaluation. ...Read more
Depends on situation: A lack of specific antibody implies that your immune system has not naturally encountered pneumococcus bacteria or that it has not responded well to previous exposure or pneumococcal vaccines (prevnar or pneumovax). This may be a sign of immune deficiency and should be discussed with a board certified allergist/immunologist. ...Read more
Measures immunity: It is common for physicians who assess persons with recurrent infections for immune deficiency to check pneumococcal antibody levels. A person with a well functioning immune system should be able to produce specific antibody levels to bacteria (especially if they have received the vaccination). If levels are low, in context of recurrent bacterial infections, further evaluation of immunity needed. ...Read more
I am currently on Retuximab maintenance and my pneumococcal and haemophilus antibodies are suboptimal - can you tell me what this means?
Dr. Tested my pneumococcal antibodies- they were low she gave me pneumo vac retest in 5 weeks, if it comes back low again. What does this mean?
CVID: Aka combined variable immunodeficiency. This test is done because you have recurrent sinusitis, bronchitis or pneumonia & screening tests for weak immune system - CBC & diff, quantitative immunoglobulins, ch50- are ok. A 2nd low test means you don't make adequate antibodies against some bacteria that infect the respiratory tract. Antibiotics & gamma globulin injections will help you. ...Read more
Very low pneumococcal anti-bodies. All other tests great. Is that serious? Given vaccine for it. What happens if my body doesn't make the antibodies?
You have to give the vaccine time to work and with time it will make antibodies
Nothing will happen ...Read more
What does low pneumococcal antibodies mean? Blood showed good immune system except that? Can it cause chronic sinusitis and bronchitis?
Yes: I assume this is a antibody level measured after the pneumococcal vaccine. If so, it means your immune system is not responding to the bacterial proteins in the normal way. Patients who mount a weak response to bacterial infections may be at higher risk for recurrent respiratory tract infections such as sinusitis and bronchitis. ...Read more
What's the implication of having low iga, low total protein, low IG subclasses, not adequately forming antibodies to pneumococcal vaccine, petichiae?
I have Primary Immune Deficiency, MS, POTS, RA, Raynauds, etc... no response to pneumovax or prevnar (pneumococcal vaccine). ANAs always neg. Sero-negative. Please help!
Workup and Mgt: There are many PIDs and some are associated with autoimmune disease. Since there is so much variation, the diagnosis can be difficult. If you are prone to infections, the pattern of the infections, type and location will help your physician determine the diagnosis and treatment. If you have lung involvement, an HRCT is helpful. Most PIDs involve B cells and I would advise B cell studies. ...Read more
I have just been I a house with a dead person and she died of pneumococcal meningitis am I in any need of antibiotics the lid was of the coffin?
Hi I just left a house where the person has been dead for 2 weeks on sunday, and she died of pneumococcal meningitis am I in need of antibiotics.?
No: The pneumococcus is widespread in the environment and the dead body does not present a danger to you. This must have been frightening for you and everyone else involved. Be strong and if this was someone you knew, remember the good times. Best wishes. ...Read more
Have pneumococcal pneumonia with fever of 104, have been on antibiotics for 2 days. Is this still normal?
IgA deficiency: Iga is an antibody, so a deficiency of IgA means your body is having trouble making that type of antibody. Iga deficiency does not cause you to be unable to make other antibodies. It just means you aren't able to make the IgA class of antibodies, so antibodies of that type will probably not be detected if they are sought, for example, in a blood test for celiac or other diseases. ...Read more
Immune Deficiency: Why do we get high blood pressure, diabetes, high cholesterol, arthritis? It just happens. Plus, quantity of antibodies does not mean quality. There is much more to simply just an antibody level that allows an immunologist to diagnose an immune deficiency. If you question the diagnosis, seek a 2nd opinion. ...Read more
Could an immunoglobulin deficiency effectively mask an autoimmune disorder from auto-antibody screens such as AMA ANA etc. Or is it a separate thing?
No: When there is a total deficiency of the immunoglobulin, there can be no autoantibody formed from that particular class of immunoglobulin. Thus it is not a masking. However this does not rule out that other immune mechanisms may not be the cause for a certain illness. ...Read more
Immunologist agreed I have malar rash. How is lupus dx'd since we can't rely on antibody or inflammatory tests w my immune deficiency and steroid tx?
Management/workup: The initial workup will include renal function testing and tests for circulating antibodies. Your steroid treatment may affect the tests for inflammation, moreso than autoantibodies which are still detectable even while being treated with steroids. Avoiding and treating infections, including CMV will be part of the management. I hope that this helps. ...Read more
I have selective antibody deficiency, hashimotos, fibromyalgia, pmdd, high blood pressure, asthma, & gerd. Now I have restless legs. Any ideas?
Multiple symptoms: You can;t separate physical disorders and/or symptoms from lifestyle. However, from your symptom complex, it would not surprise me if there are lifestyle choices you are making that are not supportive of you getting rid of some of these ailments. You are in control more than you think and it is taking a look at what you can change and what you must look to medical science to help you with. ...Read more
See Below: Recurrent infections are when someone gets too many infections in a given period of time like 10 sinus infections in a year. They can also be more severe infections less frequently like pneumonia 3 times/yr. Immune deficiency is a problem with your immune system that results in a decreased ability to fight infections. Antibiotic resistance is when an infection no longer gets betters with drug. ...Read more
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