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Doctor insights on: Pml In Children

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How can we detect pml?

How can we detect pml?

Diagnosis PML: The diagnosis is usually made by the finding of jacob-creutzfeld virus in the spinal fluid or brain biopsy. Mri findings show multifocal non enhancing lesions without mass effect in the brain's cortical white matter. ...Read more

Dr. Arnold Malerman
13 Doctors shared insights

Pml (Definition)

Progressive multifocal leukoencephalopathy (PML), = viral infection of brain ...Read more


Dr. Yo-El Ju Dr. Ju
1 doctor agreed:
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How can pml be diagnosed?

Dr. Yo-El Ju Dr. Ju
1 doctor agreed:
How can pml be diagnosed?

MRI and spinal tap: Progressive multifocal leukoencephalopathy has a characteristic appearance on on a brain mri. A lumbar puncture (spinal tap) is used to look for the virus that causes it. ...Read more

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What are the tests for pml?

What are the tests for pml?

MRI, spinal fluid: Mri, clinical exam, pathologic tissue and spinal fluid are all tests for progressive multifocal leukoencephalopathy. It depends on the presentation and suspicion for this terrible disease. ...Read more

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Is there a gentle way to treat pml?

Is there a gentle way to treat pml?

NO: Pml is caused by the jc virus. It can lie dormant in an immunocompetent host for a lifetime. In the immunocompromised host, pml is uniformly fatal without reconstitution of the immune system. There have been several reports of antiviral agents being used to treat pml in immunocompromised states, the numbers are very limited and the treatment is not gentle. To answer your question...No. ...Read more

Dr. Alan Ali Dr. Ali
1 doctor agreed:
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What are the symptoms associated with pml?

Dr. Alan Ali Dr. Ali
1 doctor agreed:
What are the symptoms associated with pml?

PML: Progressive multifocal leukoencephalopathy is a rapidly progressive viral infection of the brain caused by creutzfeldt jacob papova virus which affect support cells of the brain. Causes headaches, memory loss, speech & vision difficulties, changes in mental status, seizures, partial paralysis, limb weakness, incoordination, and finally coma & death. ...Read more

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What is the definition or description of: PML?

What is the definition or description of: PML?

PML: Progressive multifocal leukoencephalopathy (PML), = viral infection of brain that is often fatal. ...Read more

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What needs to be present for the diagnosis of pml?

What needs to be present for the diagnosis of pml?

MRI: There are characteristic MRI findings. Certain test can be done on spinal fluid too. ...Read more

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How do we prevent pml?

How do we prevent pml?

Assuming you have ms: Assuming you mean progressive multifocal leukoencephalopathy, and assuming you are on tysabri, (natalizumab) your dr. Now has the availability of serum titters to see if you are at risk. If you are, the only means of prevention is to follow titters. ...Read more

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How does pml affect people with hiv?

How does pml affect people with hiv?

PML and HIV: Progressive multifocal leukoencephalopathy affects individuals with compromised immune system disorders. In patients with aids, efforts to improve the immune system may improve the course and outcome of pml. ...Read more

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Can you please give me more information on the jc virus and pml?

Can you please give me more information on the jc virus and pml?

Virus PML: JC virus is from a prion infection, originally discovered in head hunters in New Guinea. Infection is rare and no treatment is yet available. PML is a disease of the white matter of the brain and there are many causes for most of which are either infectious or congenital ...Read more

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Does the benefit of tysabri (natalizumab) outweigh the risk of PML?

Does the benefit of tysabri (natalizumab) outweigh the risk of PML?

Individualized: Tysabri/natalizumab is an immunosuppressant used in the treatment of relapsing forms of MS. PML (progressive multifocal leukoencephaolopathy), the result of JC virus infection, is a disastrous side effect. The decision to use this drug has to be very cautiously assessed by the MS patient & his doctor & administered through a restricted program. Risk/benefit analysis is complicated & challenging. ...Read more

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What are the current pml figures while taking tyasbri? How much at risk am I at if I have a negative jcv test? And if for some reason my jcv changes..

Bad risk: The jcv test is not very definitive. Tysabri (natalizumab) lowers immune response and can cause activation of latent virus agents and prions. The risk is significant regardless of the jcv status. ...Read more

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Is PML reversible? I am beginning tecfidera and the warning labels are intimidating.

Is PML reversible? I am beginning tecfidera and the warning labels are intimidating.

If I understand your: Question, you have PML--clearly a very rare and debilitating viral disease--and your are wondering if anything can "reverse" it. My understanding is that there are no truly effective drugs that cure or reverse PML. Tecfidera is typically used in multiple sclerosis; perhaps your neurologist is suggesting you might try it due to some trial or clinical evidence of benefit. Very individual decision. ...Read more

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Is it possible that or does the drug methetrexate cause progressive multifocal leukoencephalopathy (pml)?

Is it possible that or does the drug methetrexate cause progressive multifocal leukoencephalopathy (pml)?

Yes: However, that issue is incredible rare if Methotrexate is used alone and not in combination with other agents including prednisone, biologics or other immunosuppressives. ...Read more

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How common is PML from Rituxan (rituximab) for lymphoma?

How common is PML from Rituxan (rituximab) for lymphoma?

Rituximab: Progressive multi focal leukoencephalopathy (PML) can be associated with Rituximab treatment and with other drugs which cause immunosuppression. It is s rare complication. In one study 52 cases were reported in patients with lymphoma and other myeloproliferative diseases. The incidence was less than 1%. However the drug is being used more and more and the incidence may increase. ...Read more

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Should I be concerned if my mom has MS and she is on a new drug that may cause pml. What is pml?

PML: Pml (progressive multi-focal leukoencephalopathy) is a viral infection of the brain that is caused by the jc virus. It had been seen in cancer and severely immunocompromised patients. In these patients, the illness was progressive and fatal. In multiple sclerosis, the risk can be minimized by having the jc virus titer and if negative and no prior history of immunosupression, then risk is low. ...Read more

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What is the difference between progresive multifocal leukoencephilopathy (pml) and reversible posterior leukoencephalopathy syndrome (rpls)?

What is the difference between progresive multifocal leukoencephilopathy (pml) and reversible posterior leukoencephalopathy syndrome (rpls)?

Different problems: Pml is a viral disease affecting the brain and occurs in patients with compromised immune systems such as those with aids, transplants, cancer, etc. Rpls is a reversible syndrome of headaches, seizures, confusion, and other symptoms due to medications, high blood pressure, etc. And improves upon treatment of the underlying disorder. ...Read more

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How often do people on "rituximab" show pml symptoms, while being treated for ttp? Does it worth to take the risk? Please answer as quick as poss.

How often do people on "rituximab" show pml symptoms, while being treated for ttp? Does it worth to take the risk? Please answer as quick as poss.

Extremely rare issue: Pml is beyond rare and generally occurs only when t cell and b cell agents are used at the same time although it can occur with Rituxan (rituximab) alone. Yes it is worth the risk. ...Read more

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How many different ways are there to correctly and positively diagnose the brain virus pml:?

How many different ways are there to correctly and positively diagnose the brain virus pml:?

Approaches: Can do a blood test to screen, an anti-JCV antibody index, but if the disease is present MRI of brain shows characteristic patterns, and spinal fluid PCR testing can be very positive. ...Read more

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My neurologist has urged me to stay on tysabri (natalizumab) despite the risks of pml (positive to jc) is this a hint that my MS is much worse than I thought?

My neurologist has urged me to stay on tysabri (natalizumab) despite the risks of pml (positive to jc) is this a hint that my MS is much worse than I thought?

Management: The risk of PML becomes more significant the longer you take Tysabri, (natalizumab) and 2yrs is the turning point, but risk is still low, about 1 in 90. However, for some pts, this still is too high, and they switch to Gilenya at 2yrs. This is a calculated gamble, and should be your decision, not just your doctor's. The severity of your MS is just one part of this, so talk at length with your neurologist. ...Read more

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I am married in 1 year no children en problem in my health would you eat that type of food can be eat him in my husband and me?

I am married in 1 year no children en problem in my health would you eat that type of food can be eat him in my husband and me?

Chocolate: This is not scientific but neither is having babies! Try anything chocolate. Eat romantic foods. Avoid alcohol and stimulants. Relax. Enjoy being married without children. The more you relax and enjoy your spouse the better your marriage will be and the more prepared you we be to be a parent. You are learning patience and you will need it! OB doctors have solutions for you when wanted ...Read more

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I can have children?

I can have children?

Hopefully: If you want to have children but are not trying presently, there are some tests that can help tell you more. But the only way to absolutely prove one way or another is to attempt pregnancy with your partner. See your gynecologist: they can help you with the available tests. ...Read more

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Why children feel giddy?

Why children feel giddy?

Vertigo?: Many children get very dizzy at times without definite cause. Some are due to ear infections or ear fluid pressure. Other times it may happen because of spinning around. Episodic vertigo is a very dramatic event in some children when they look terrified and have to hold on for a few moments, then return to normal. This is usually benign but needs a good evaluation. ...Read more

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Why can't I have children?

Why can't I have children?

Consultation time: Time to consult with your ob/gyn or get a referral to a fertility center. Both you & your partner need to be evaluated. There are many possible issues & many available solutions. ...Read more

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Is 40 to old to have children?

Is 40 to old to have children?

Maybe, maybe not: Many women are quite successful in their pregnancies at 40.There is some reduced fertility & increased risk of complications, but if your basic health is good & you understand the increased risk of down syndrome, I don't see any reason to say it's too late. ...Read more

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What stops you from having children?

What stops you from having children?

STD's and PID: Sexually transmitted diseases can lead to pelvic inflammatory disease. PID can lead to later infertility. ...Read more

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Can icjd be passed on to your children?

Can icjd be passed on to your children?

CJD: The familial form can be inherited in @10% of cases, through gene mutation. ...Read more

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How to stop woomting and pain in children?

How to stop woomting and pain in children?

Vomiting: For a simple gastroenteritis, gut rest (nothing to eat or drink for 2-3 hrs) followed by small sips of clear fluids, frequently (goal depending on age of child 1-4 oz/hr). The presence of pain is more worrisome and I would recommend taking the child to their doctor for a hands-on examination to rule out anything more serious. ...Read more

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How would keep my guns away from children?

How would keep my guns away from children?

Safe/locks: A good gun safe can double as a home for some family valuables. There are a number of trigger locks and quick entry safes on the market that provide quick access but eliminate child entry. As mentioned, kids taught gun handling and safety as early as age 4 are less likely to play with any gun they find anywhere. ...Read more