Doctor insights on:
Pml In Children
NO: Pml is caused by the jc virus. It can lie dormant in an immunocompetent host for a lifetime. In the immunocompromised host, pml is uniformly fatal without reconstitution of the immune system. There have been several reports of antiviral agents being used to treat pml in immunocompromised states, the numbers are very limited and the treatment is not gentle. To answer your question...No. ...Read more
PML: Progressive multifocal leukoencephalopathy is a rapidly progressive viral infection of the brain caused by creutzfeldt jacob papova virus which affect support cells of the brain. Causes headaches, memory loss, speech & vision difficulties, changes in mental status, seizures, partial paralysis, limb weakness, incoordination, and finally coma & death. ...Read more
Assuming you have ms: Assuming you mean progressive multifocal leukoencephalopathy, and assuming you are on tysabri, (natalizumab) your dr. Now has the availability of serum titters to see if you are at risk. If you are, the only means of prevention is to follow titters. ...Read more
Individualized: Tysabri/natalizumab is an immunosuppressant used in the treatment of relapsing forms of MS. PML (progressive multifocal leukoencephaolopathy), the result of JC virus infection, is a disastrous side effect. The decision to use this drug has to be very cautiously assessed by the MS patient & his doctor & administered through a restricted program. Risk/benefit analysis is complicated & challenging. ...Read more
If I understand your: Question, you have PML--clearly a very rare and debilitating viral disease--and your are wondering if anything can "reverse" it. My understanding is that there are no truly effective drugs that cure or reverse PML. Tecfidera is typically used in multiple sclerosis; perhaps your neurologist is suggesting you might try it due to some trial or clinical evidence of benefit. Very individual decision. ...Read more
Is it possible that or does the drug methetrexate cause progressive multifocal leukoencephalopathy (pml)?
Rituximab: Progressive multi focal leukoencephalopathy (PML) can be associated with Rituximab treatment and with other drugs which cause immunosuppression. It is s rare complication. In one study 52 cases were reported in patients with lymphoma and other myeloproliferative diseases. The incidence was less than 1%. However the drug is being used more and more and the incidence may increase. ...Read more
PML: Pml (progressive multi-focal leukoencephalopathy) is a viral infection of the brain that is caused by the jc virus. It had been seen in cancer and severely immunocompromised patients. In these patients, the illness was progressive and fatal. In multiple sclerosis, the risk can be minimized by having the jc virus titer and if negative and no prior history of immunosupression, then risk is low. ...Read more
What is the difference between progresive multifocal leukoencephilopathy (pml) and reversible posterior leukoencephalopathy syndrome (rpls)?
Different problems: Pml is a viral disease affecting the brain and occurs in patients with compromised immune systems such as those with aids, transplants, cancer, etc. Rpls is a reversible syndrome of headaches, seizures, confusion, and other symptoms due to medications, high blood pressure, etc. And improves upon treatment of the underlying disorder. ...Read more
How often do people on "rituximab" show pml symptoms, while being treated for ttp? Does it worth to take the risk? Please answer as quick as poss.
Extremely rare issue: Pml is beyond rare and generally occurs only when t cell and b cell agents are used at the same time although it can occur with Rituxan (rituximab) alone. Yes it is worth the risk. ...Read more
My neurologist has urged me to stay on tysabri (natalizumab) despite the risks of pml (positive to jc) is this a hint that my MS is much worse than I thought?
Management: The risk of PML becomes more significant the longer you take Tysabri, (natalizumab) and 2yrs is the turning point, but risk is still low, about 1 in 90. However, for some pts, this still is too high, and they switch to Gilenya at 2yrs. This is a calculated gamble, and should be your decision, not just your doctor's. The severity of your MS is just one part of this, so talk at length with your neurologist. ...Read more
I am married in 1 year no children en problem in my health would you eat that type of food can be eat him in my husband and me?
Chocolate: This is not scientific but neither is having babies! Try anything chocolate. Eat romantic foods. Avoid alcohol and stimulants. Relax. Enjoy being married without children. The more you relax and enjoy your spouse the better your marriage will be and the more prepared you we be to be a parent. You are learning patience and you will need it! OB doctors have solutions for you when wanted ...Read more
Vertigo?: Many children get very dizzy at times without definite cause. Some are due to ear infections or ear fluid pressure. Other times it may happen because of spinning around. Episodic vertigo is a very dramatic event in some children when they look terrified and have to hold on for a few moments, then return to normal. This is usually benign but needs a good evaluation. ...Read more
Vomiting: For a simple gastroenteritis, gut rest (nothing to eat or drink for 2-3 hrs) followed by small sips of clear fluids, frequently (goal depending on age of child 1-4 oz/hr). The presence of pain is more worrisome and I would recommend taking the child to their doctor for a hands-on examination to rule out anything more serious. ...Read more
Safe/locks: A good gun safe can double as a home for some family valuables. There are a number of trigger locks and quick entry safes on the market that provide quick access but eliminate child entry. As mentioned, kids taught gun handling and safety as early as age 4 are less likely to play with any gun they find anywhere. ...Read more