Doctor insights on:
Pml In Children
NO: Pml is caused by the jc virus. It can lie dormant in an immunocompetent host for a lifetime. In the immunocompromised host, pml is uniformly fatal without reconstitution of the immune system. There have been several reports of antiviral agents being used to treat pml in immunocompromised states, the numbers are very limited and the treatment is not gentle. To answer your question...No. ...Read more
PML: Progressive multifocal leukoencephalopathy is a rapidly progressive viral infection of the brain caused by creutzfeldt jacob papova virus which affect support cells of the brain. Causes headaches, memory loss, speech & vision difficulties, changes in mental status, seizures, partial paralysis, limb weakness, incoordination, and finally coma & death. ...Read more
Assuming you have ms: Assuming you mean progressive multifocal leukoencephalopathy, and assuming you are on tysabri, (natalizumab) your dr. Now has the availability of serum titters to see if you are at risk. If you are, the only means of prevention is to follow titters. ...Read moreSee 1 more doctor answer
Individualized: Tysabri/natalizumab is an immunosuppressant used in the treatment of relapsing forms of MS. PML (progressive multifocal leukoencephaolopathy),the result of JC virus infection, is a disastrous side effect.The decision to use this drug has to be very cautiously assessed by the MS patient & his doctor & administered through a restricted program. Risk/benefit analysis is complicated & challenging. ...Read more
If I understand your: question, you have PML--clearly a very rare and debilitating viral disease--and your are wondering if anything can "reverse" it. My understanding is that there are no truly effective drugs that cure or reverse PML. Tecfidera is typically used in multiple sclerosis; perhaps your neurologist is suggesting you might try it due to some trial or clinical evidence of benefit. Very individual decision. ...Read more
Is it possible that or does the drug methetrexate cause progressive multifocal leukoencephalopathy (pml)?
Rituximab: Progressive multi focal leukoencephalopathy (PML) can be associated with Rituximab treatment and with other drugs which cause immunosuppression. It is s rare complication. In one study 52 cases were reported in patients with lymphoma and other myeloproliferative diseases. The incidence was less than 1%. However the drug is being used more and more and the incidence may increase. ...Read more
PML: Pml (progressive multi-focal leukoencephalopathy) is a viral infection of the brain that is caused by the jc virus. It had been seen in cancer and severely immunocompromised patients. In these patients, the illness was progressive and fatal. In multiple sclerosis, the risk can be minimized by having the jc virus titer and if negative and no prior history of immunosupression, then risk is low. ...Read moreSee 1 more doctor answer
What is the difference between progresive multifocal leukoencephilopathy (pml) and reversible posterior leukoencephalopathy syndrome (rpls)?
Different problems: Pml is a viral disease affecting the brain and occurs in patients with compromised immune systems such as those with aids, transplants, cancer, etc. Rpls is a reversible syndrome of headaches, seizures, confusion, and other symptoms due to medications, high blood pressure, etc. And improves upon treatment of the underlying disorder. ...Read more
How often do people on "rituximab" show pml symptoms, while being treated for ttp? Does it worth to take the risk? Please answer as quick as poss.
My neurologist has urged me to stay on tysabri (natalizumab) despite the risks of pml (positive to jc) is this a hint that my MS is much worse than i thought?
Management: The risk of PML becomes more significant the longer you take Tysabri, (natalizumab) and 2yrs is the turning point, but risk is still low, about 1 in 90. However, for some pts, this still is too high, and they switch to Gilenya at 2yrs. This is a calculated gamble, and should be your decision, not just your doctor's. The severity of your MS is just one part of this, so talk at length with your neurologist. ...Read moreSee 1 more doctor answer