Top
10
Doctor insights on: Pml

Share
Dr. Hirenkumar Italia
13 doctors shared insights

Pml (Overview)

PML is a rare condition in which the material covering nerves in specific regions of the brain (known as white matter) are damaged. PML is due to a viral infection, and it is usually seen in individuals with a weak immune system. Symptoms are caused by the damage in the brain, and can include loss of coordination, memory loss, vision problems, and troubles with language ability.


1

1
How can we detect pml?

How can we detect pml?

Diagnosis PML: The diagnosis is usually made by the finding of jacob-creutzfeld virus in the spinal fluid or brain biopsy. Mri findings show multifocal non enhancing lesions without mass effect in the brain's cortical white matter. ...Read more

See 1 more doctor answer
Dr. Hirenkumar Italia
13 doctors shared insights

Pml (Overview)

PML is a rare condition in which the material covering nerves in specific regions of the brain (known as white matter) are damaged. PML is due to a viral infection, and it is usually seen in individuals with a weak immune system. Symptoms are caused by the damage in the brain, and can include loss of coordination, memory loss, vision problems, and troubles with language ability.


2

2
How does pml affect people with hiv?

How does pml affect people with hiv?

PML and HIV: Progressive multifocal leukoencephalopathy affects individuals with compromised immune system disorders. In patients with aids, efforts to improve the immune system may improve the course and outcome of pml. ...Read more

See 1 more doctor answer
3

3
What are the symptoms associated with pml?

What are the symptoms associated with pml?

PML: Progressive multifocal leukoencephalopathy is a rapidly progressive viral infection of the brain caused by creutzfeldt jacob papova virus which affect support cells of the brain. Causes headaches, memory loss, speech & vision difficulties, changes in mental status, seizures, partial paralysis, limb weakness, incoordination, and finally coma & death. ...Read more

4

4
What needs to be present for the diagnosis of pml?

What needs to be present for the diagnosis of pml?

MRI: There are characteristic MRI findings. Certain test can be done on spinal fluid too. ...Read more

See 1 more doctor answer
Dr. Yo-El Ju Dr. Ju
1 doctor agreed:
5

5
How can pml be diagnosed?

Dr. Yo-El Ju Dr. Ju
1 doctor agreed:
How can pml be diagnosed?

MRI and spinal tap: Progressive multifocal leukoencephalopathy has a characteristic appearance on on a brain mri. A lumbar puncture (spinal tap) is used to look for the virus that causes it. ...Read more

See 1 more doctor answer
6

6
What are the current pml figures while taking tyasbri? How much at risk am I at if I have a negative jcv test? And if for some reason my jcv changes..

What are the current pml figures while taking tyasbri? How much at risk am I at if I have a negative jcv test? And if for some reason my jcv changes..

Bad risk: The jcv test is not very definitive. Tysabri lowers immune response and can cause activation of latent virus agents and prions. The risk is significant regardless of the jcv status. ...Read more

7

7
What are the tests for pml?

What are the tests for pml?

MRI, spinal fluid: Mri, clinical exam, pathologic tissue and spinal fluid are all tests for progressive multifocal leukoencephalopathy. It depends on the presentation and suspicion for this terrible disease. ...Read more

8

8
Should i be concerned if my mom has MS and she is on a new drug that may cause pml. What is pml?

Should i be concerned if my mom has MS and she is on a new drug that may cause pml. What is pml?

PML: Pml (progressive multi-focal leukoencephalopathy) is a viral infection of the brain that is caused by the jc virus. It had been seen in cancer and severely immunocompromised patients. In these patients, the illness was progressive and fatal. In multiple sclerosis, the risk can be minimized by having the jc virus titer and if negative and no prior history of immunosupression, then risk is low. ...Read more

See 1 more doctor answer
9

9
Is there a gentle way to treat pml?

Is there a gentle way to treat pml?

NO: Pml is caused by the jc virus. It can lie dormant in an immunocompetent host for a lifetime. In the immunocompromised host, pml is uniformly fatal without reconstitution of the immune system. There have been several reports of antiviral agents being used to treat pml in immunocompromised states, the numbers are very limited and the treatment is not gentle. To answer your question...No. ...Read more

10

10
How often do people on "rituximab" show pml symptoms, while being treated for ttp? Does it worth to take the risk? Please answer as quick as poss.

How often do people on "rituximab" show pml symptoms, while being treated for ttp? Does it worth to take the risk? Please answer as quick as poss.

Extremely rare issue: Pml is beyond rare and generally occurs only when t cell and b cell agents are used at the same time although it can occur with Rituxan alone. Yes it is worth the risk. ...Read more