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Doctor insights on: Pm Scl Antibody

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If I have a high positive ANA (1:640) speckled, nucleolar and low positive SMA (1:40), what further tests do I need to do? (Negative SS-A, SS-B, Smith, RNP, SCL-70, Anti Jo Abs)

If I have a high positive ANA (1:640) speckled, nucleolar and low positive SMA (1:40), what further tests do I need to do?  (Negative SS-A, SS-B, Smith, RNP, SCL-70, Anti Jo Abs)

? anti dsDNA: You've probably already had these more basic tests: complete blood count, sedimentation rate, C-reactive protein, urinalysis & rheumatoid factor. It appears to me that the ANA results with slight positive anti-Smith may suggest lupus; you need an antibody to double-stranded DNA (anti dsDNA) which is very specific & somewhat sensitive for lupus.All this needs to be correlated by your doc/specialist ...Read more

Antibody (Definition)

An antibody is a protein the body's immune system makes to identify potentially harmful substances in the body. Antibodies attach to the substance on a molecular level and mark it so the immune ...Read more


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Blood tests showed high antibodies to: ana, ssdna, sm, rnp/sm, ssa(ro), ssb(la), scl-70, centromere. Is this likely lupus or a different automimmune?

Blood tests showed high  antibodies to: ana, ssdna, sm, rnp/sm, ssa(ro), ssb(la), scl-70, centromere.  Is this likely lupus or a different automimmune?

Prob false positive: To have all these antibodies to be positive is suggestive of a false positive result. Virus infection can cause similiar findings. Ultimately these results have to be interpretted in the context of your doctor's findings. Talk to your doctor. ...Read more

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What is the definition or description of: scl-70 antibody?

What is the definition or description of: scl-70 antibody?

Autoimmune: Autoantibody to centromere proteins scl-70, topoisomerase 1, found in patients with autoimmune disease and more specific for the autoimmune disease crest (calcinosis, raynaud phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia). Can also be found in patients with scleroderma. ...Read more

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I have lupus- diagnosed w/labs and symptoms.But had no antibodies positive- all were 0 except my ssa was 8 (0-40 is neg) & scl-70 was 3 (0-40 neg) should I be concerned about scleroderma? Very scared!

Rheumatologist. ...: You need to see a rheumatologist to sort out the lupus question. Lots of symptoms but zero lab evidence may not necessarily be lupus. Make sure diagnosis is right! ...Read more

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Blood tests showed high antibodies to: ana, ssdna, sm, rnp/sm, ssa(ro), ssb(la), scl-70, centromere. Is this likely lupus or a different automimmune?

Prob false positive: To have all these antibodies to be positive is suggestive of a false positive result. Virus infection can cause similiar findings. Ultimately these results have to be interpretted in the context of your doctor's findings. Talk to your doctor. ...Read more

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What would cause a high positive ANA (1:640) speckled, nucleolar with a low positive smooth muscle antibody (1:40) but negative SS-A, SS-B, anti-Smith, RNP, SCL-70, Anti Jo antibodies? Liver disease?

What would cause a high positive ANA (1:640) speckled, nucleolar with a low positive smooth muscle antibody (1:40) but negative SS-A, SS-B, anti-Smith, RNP, SCL-70, Anti Jo antibodies? Liver disease?

Probably normal: Many people have a positive ANA without being sick. If you also have elevated liver enzymes, a workup for autoimmune hepatitis may be continued, but if there's nothing to suggest a liver problem biochemically, I'd not be in a hurry to diagnose despite anti-smooth-muscle. ANA means nothing apart from the clinical picture. Best wishes. ...Read more

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Possibility of having scleroderma w/ negative scl-70 & negative anti-centromere antibodies?no raynauds,but bad GERD w/ PPI's not workin, I have lupus

History / physical: Scleroderma is diagnosed on history and physical exam. Without Raynaud's, it's unlikely. The labs aren't altogether sensitive. I'd address the GERD as a separate issue, and continue as you're probably already doing keeping a close eye on your lupus as a proactive patient. Best wishes. ...Read more

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I've temp 4 6 days after 5 PM,got antibiotics 3 days ago.I sweat during day when no temp n cool myself below normal temp.What can I do 2 stop sweating?

I've temp 4 6 days after 5 PM,got antibiotics 3 days ago.I sweat during day when no temp n cool myself below normal temp.What can I do 2 stop sweating?

Sweating: This is one of the body's mechanisms to reduce core temperature. Do not know how you have been measuring your temp, but it sounds as if you have had fevers and while sweating are breaking the fever. You cannot and should not interfere with this. If you continue the chances are that you should go and be medically evaluated. Good luck. ...Read more

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I'm taking an antibiotic for strep throat. I take it at 10 AM 3 PM and then 8 PM is it OK regiment ?

I'm taking an antibiotic for strep throat. I take it at 10 AM 3 PM and then 8 PM is it OK regiment 
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Yes: Taking ? Amoxicillin twice daily is the recommended interval, based on its metabolism. Taking it three times a day will not hurt but is not necessary. All the best. ...Read more