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Doctor insights on: Pm Scl Antibody

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Sm/rnp antibody- ANA choice- positive, speckled/titer: 1:1280; sm & rnp (done alone) negative; sm/rnp antibody (together?) positive 3.0 guessing mctd?

Sm/rnp antibody- ANA choice- positive, speckled/titer: 1:1280; sm & rnp (done alone) negative; sm/rnp antibody (together?) positive 3.0 guessing mctd?

Heads up: One of the things that's frustrating about these antibody tests looking for different connective tissue diseases is that they are difficult to do and are fraught with pitfalls. I suspect you've had at least one lab error to complicate your workup. Have you have a tube test for u1-rnp? Your clinical symptoms and signs actually tell more about your diagnosis ; best direction for treatment. ...Read more

Antibody (Definition)

An antibody is a protein the body's immune system makes to identify potentially harmful substances in the body. Antibodies attach to the substance on a molecular level and mark it so the immune ...Read more


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What would cause a high positive ANA (1:640) speckled, nucleolar with a low positive smooth muscle antibody (1:40) but negative SS-A, SS-B, anti-Smith, RNP, SCL-70, Anti Jo antibodies? Liver disease?

What would cause a high positive ANA (1:640) speckled, nucleolar with a low positive smooth muscle antibody (1:40) but negative SS-A, SS-B, anti-Smith, RNP, SCL-70, Anti Jo antibodies? Liver disease?

Probably normal: Many people have a positive ANA without being sick. If you also have elevated liver enzymes, a workup for autoimmune hepatitis may be continued, but if there's nothing to suggest a liver problem biochemically, I'd not be in a hurry to diagnose despite anti-smooth-muscle. ANA means nothing apart from the clinical picture. Best wishes. ...Read more

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Blood tests showed high antibodies to: ana, ssdna, sm, rnp/sm, ssa(ro), ssb(la), scl-70, centromere. Is this likely lupus or a different automimmune?

Blood tests showed high  antibodies to: ana, ssdna, sm, rnp/sm, ssa(ro), ssb(la), scl-70, centromere.  Is this likely lupus or a different automimmune?

Prob false positive: To have all these antibodies to be positive is suggestive of a false positive result. Virus infection can cause similiar findings. Ultimately these results have to be interpretted in the context of your doctor's findings. Talk to your doctor. ...Read more

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ANA 1:80 speckled, SM, RNP, SCL-70 detected.Leukocyte, urate, alkaline phosphate,creatinine low. Albumin, triglycerides high. Pos HAV, HBV. Rhem. Neg?

ANA 1:80 speckled, SM, RNP, SCL-70 detected.Leukocyte, urate, alkaline phosphate,creatinine low. Albumin, triglycerides high. Pos HAV, HBV. Rhem. Neg?

Not enough info: Lab tests need to be evaluated in the context of the clinical symptoms. You need this issue evaluated by a rheumatologist ...Read more

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ANA positive SSA SSB weekly positive SCL weekly positive RNP SM weekly positive. Any implications? What are the differential diagnosis? WaDoes it mean

ANA positive SSA SSB weekly positive SCL weekly positive RNP SM weekly positive. Any implications? What are the differential diagnosis? WaDoes it mean

Pos auto ab tests: You are describing positive tests for auto antibodies. The differential diagnosis can be extensive. I am assuming a rheumatologist has ordered these tests? You need f/u with them to educate you what they mean, what further tests may need to be done and review your symptoms. Proper rheum DX is not based only on test results, but exam findings and symptoms of patient. Good luck. ...Read more

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What does this mean ? SSB(La)IGG Positive 85 SSA(Ro)AB IGG Neg. ANA NEG. SED RATE Neg. CRP Neg. RF NEG.

Depends: All lab results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that antibodies to SSA suggest auto-immune disorder, however, if that is the only abnormal test and you do not have any symptoms, I would leave it alone and re-evaluate in six months. ...Read more

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How about Ana screen positive, Ana titer (ifa) 1:80 Hi, and pattern speckled?

How about it?: Up to a quarter of women your age have an ANA (immunofluorescent antibody) at a low titer like yours with a speckled pattern. If there's a question of whether you have lupus or one of its relatives, it's a piece of information to note and file for future reference. A negative ANA would rule several things out. Your result proves nothing positive. Best wishes. ...Read more

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(Biopsy DLE Inconclusive)ds-DNA Normal.Weak Positive ANA,ENA R Positive ANT RNP positive FBC &Urine Ok.Photosen,Rash face&Ears blister fingers... SLE?

(Biopsy DLE Inconclusive)ds-DNA Normal.Weak Positive ANA,ENA R Positive ANT RNP positive FBC &Urine Ok.Photosen,Rash face&Ears blister fingers... SLE?

No: DLE , even if you have it, does not necessarily translate into SLE in the absence of other system involvement. True blisters are not usually found with DLE. Have you been checked for porphyria? ...Read more

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I'm having negative DNA ,Sm and Rnp antibodies, but positive sm/rnp antibody,and high ANA titre speckled,so what is the diagnosis ?

Lupus: These serologies are rather non specific. The speckled ANA is non specific. In Systemic Lupus Erythematosis (SLE) it is usually homogeneous in its staining. Anti-Sm and Anti RNP can be see in mixed connective-tissue diseases and overlaps with SLE, scleroderma and myositis. As often is the case a specific diagnosis cannot be made. You need to see a Rheumatologist. ...Read more

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My serum test is negative for endomysial antibody iga, ttg tissue transglutasminase iga, gliadin antibody igg. But positive for gliadin antibody iga?

My serum test is negative for endomysial antibody  iga, ttg tissue transglutasminase iga, gliadin antibody igg. But positive for gliadin  antibody iga?

Treat the person: Lab tests mean nothing in isolation, and have many false positives and false negatives. The decision to make a trial of a gluten-free diet will be between you and your gastroenterologist or dermatologist based on the big picture. ...Read more

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Anti ro ssa was low but present. anti TG antiTpo antibodies elevated but ana w/ panel was (-) euthyroid.has s/s responds to plaquenil (hydroxychloroquine) Differential Dx?

Anti ro ssa was low but present. anti TG antiTpo antibodies elevated but ana w/ panel was (-) euthyroid.has s/s responds to plaquenil (hydroxychloroquine) Differential Dx?

Sjögren's syndrome: Anti-ssa antibodies are most commonly associated with Sjögren's syndrome, but it does not confirm a diagnosis. Pts should may have symptoms of dry eyes and dry mouth, which are classic for Sjögren's syndrome. These ab's are also associated with connective tissue diseases such as lupus or SLE. However, a pt must have clinical and lab abnormalities to meet the diagnosis. ...Read more

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Cardiolipin antibodies IgM and urine protein 72mg/l ? Ana negative.

Cardiolipin antibodies IgM and urine protein 72mg/l ? Ana negative.

See details: The urine protein is within normal limits. How strongly positive is the igm cardiolipin. Only high levels of positivity have any clinical significance. Why were the tests ordered in the first place? ...Read more

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Lupus panel negative. Sed rate 30 should b under 20. Ana positive w/ spec pattern. Serum protein electrophoresis test normal. Cbc ok. Metabolic ok.?

Lupus panel negative. Sed rate 30 should b under 20. Ana positive w/ spec pattern. Serum protein electrophoresis test normal. Cbc  ok. Metabolic ok.?

Any joint pain?: Positive ANA and elevated sed rate. If you have joint pains it would be advisable to follow up with a rheumatologist. You have some kind of inflammatory process going on. Both test are very nonspecific and further work-up is needed. ...Read more

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C reactive protein 0.81h Ana screen, IFA positive Ana pattern homogeneous Ana titter 1:80H What's wrong with me ?

Maybe nothing: C reactive protein is famously insensitive and nonspecific. Many young women have an ANA titer like yours. The diagnosis, if one is to be made, will be on history and physical exam. ...Read more

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Hiv ab,1/2, eia with relx result repeatedly reactive. HIV 1/2ab differentiation w/refl hiv1 antibody negative hiv2 antibody negative. pos or neg hiv?

Hiv ab,1/2, eia with relx result repeatedly reactive. HIV 1/2ab differentiation w/refl hiv1 antibody negative hiv2 antibody negative. pos or neg hiv?

It depends: In a situation like this you have one positive test and one negative test. The lab should run a tie-breaker test (HIV RNA) to give you a real answer. Also, the first test may be an older test 2nd or 3rd generation) instead of the latest 4th generation) test. It also depends on if you have flu-Like symptoms. Seek help from a specialist in HIV who can help you understand. ...Read more

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If I have a high positive ANA (1:640) speckled, nucleolar and low positive SMA (1:40), what further tests do I need to do? (Negative SS-A, SS-B, Smith, RNP, SCL-70, Anti Jo Abs)

If I have a high positive ANA (1:640) speckled, nucleolar and low positive SMA (1:40), what further tests do I need to do?  (Negative SS-A, SS-B, Smith, RNP, SCL-70, Anti Jo Abs)

? anti dsDNA: You've probably already had these more basic tests: complete blood count, sedimentation rate, C-reactive protein, urinalysis & rheumatoid factor. It appears to me that the ANA results with slight positive anti-Smith may suggest lupus; you need an antibody to double-stranded DNA (anti dsDNA) which is very specific & somewhat sensitive for lupus.All this needs to be correlated by your doc/specialist ...Read more

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Blood tests showed high antibodies to: ana, ssdna, sm, rnp/sm, ssa(ro), ssb(la), scl-70, centromere. Is this likely lupus or a different automimmune?

Prob false positive: To have all these antibodies to be positive is suggestive of a false positive result. Virus infection can cause similiar findings. Ultimately these results have to be interpretted in the context of your doctor's findings. Talk to your doctor. ...Read more

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What is the definition or description of: scl-70 antibody?

Autoimmune: Autoantibody to centromere proteins scl-70, topoisomerase 1, found in patients with autoimmune disease and more specific for the autoimmune disease crest (calcinosis, raynaud phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia). Can also be found in patients with scleroderma. ...Read more

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I have lupus- diagnosed w/labs and symptoms.But had no antibodies positive- all were 0 except my ssa was 8 (0-40 is neg) & scl-70 was 3 (0-40 neg) should I be concerned about scleroderma? Very scared!

Rheumatologist. ...: You need to see a rheumatologist to sort out the lupus question. Lots of symptoms but zero lab evidence may not necessarily be lupus. Make sure diagnosis is right! ...Read more

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Blood tests showed high antibodies to: ana, ssdna, sm, rnp/sm, ssa(ro), ssb(la), scl-70, centromere. Is this likely lupus or a different automimmune?

Prob false positive: To have all these antibodies to be positive is suggestive of a false positive result. Virus infection can cause similiar findings. Ultimately these results have to be interpretted in the context of your doctor's findings. Talk to your doctor. ...Read more

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What would cause a high positive ANA (1:640) speckled, nucleolar with a low positive smooth muscle antibody (1:40) but negative SS-A, SS-B, anti-Smith, RNP, SCL-70, Anti Jo antibodies? Liver disease?

Probably normal: Many people have a positive ANA without being sick. If you also have elevated liver enzymes, a workup for autoimmune hepatitis may be continued, but if there's nothing to suggest a liver problem biochemically, I'd not be in a hurry to diagnose despite anti-smooth-muscle. ANA means nothing apart from the clinical picture. Best wishes. ...Read more

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Possibility of having scleroderma w/ negative scl-70 & negative anti-centromere antibodies?no raynauds,but bad GERD w/ PPI's not workin, I have lupus

Possibility of having scleroderma w/ negative scl-70 & negative anti-centromere antibodies?no raynauds,but bad GERD w/ PPI's not workin, I have lupus

History / physical: Scleroderma is diagnosed on history and physical exam. Without Raynaud's, it's unlikely. The labs aren't altogether sensitive. I'd address the GERD as a separate issue, and continue as you're probably already doing keeping a close eye on your lupus as a proactive patient. Best wishes. ...Read more

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I've temp 4 6 days after 5 PM,got antibiotics 3 days ago.I sweat during day when no temp n cool myself below normal temp.What can I do 2 stop sweating?

I've temp 4 6 days after 5 PM,got antibiotics 3 days ago.I sweat during day when no temp n cool myself below normal temp.What can I do 2 stop sweating?

Sweating: This is one of the body's mechanisms to reduce core temperature. Do not know how you have been measuring your temp, but it sounds as if you have had fevers and while sweating are breaking the fever. You cannot and should not interfere with this. If you continue the chances are that you should go and be medically evaluated. Good luck. ...Read more

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I'm taking an antibiotic for strep throat. I take it at 10 AM 3 PM and then 8 PM is it OK regiment ?

I'm taking an antibiotic for strep throat. I take it at 10 AM 3 PM and then 8 PM is it OK regiment 
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Yes: Taking ? Amoxicillin twice daily is the recommended interval, based on its metabolism. Taking it three times a day will not hurt but is not necessary. All the best. ...Read more

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Can I still get pregnant if I took plan b tues morning (11 am) and then took Bactrim (sulfamethoxazole and trimethoprim) antibiotic Thurs.( 7 pm) ?

Can I still get pregnant if I took plan b tues morning (11 am) and then took Bactrim (sulfamethoxazole and trimethoprim) antibiotic Thurs.( 7 pm) ?

Yes you can: If you're ovulating & having relations with a fertile male then, pregnancy's ALWAYS POSSIBLE no matter if you're on Plan C-Z. Nothing is 100% geared against pregnancy except living on Mars right now with a bunch of Dr. Seuss's Sneetches. BUT, even that will change in the 2035 so beware (2018 if the Inspiration Mars crew discovers there's a Starbucks on the surface as they boomerang around Mars)! ...Read more

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I currently have strep throat but no antibiotics. I'm taking some alkaseltzer. Would these tylenole pm's do the trick or what home remedies do you suggest?

I currently have strep throat but no antibiotics. I'm taking some alkaseltzer. Would these tylenole pm's do the trick or what home remedies do you suggest?

None: If you truly have a strep throat it will get better in about 7 days without antibiotic treatment but if you do this you run the risk of getting the serious post streptococcal sequella of rheumatic fever or glomerulonephritis. You need to take a full 10 days of a penicillin antibiotic to prevent getting these sequella. Symptomatic treatment includes throat lozenges, cepacol throat spray and tylenol (acetaminophen). ...Read more

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When should I return to work? Saturday pm i was admitted to the ER for bleeding kidneys, which turned out to be a serious kidney infection where my kidneys almost shut down. They gave me IV antibiotics and I have 7 days left on cibrofloxan 500 mg. But i a

When should I return to work? Saturday pm i was admitted to the ER for bleeding kidneys, which turned out to be a serious kidney infection where my kidneys almost shut down. They gave me IV antibiotics and I have 7 days left on cibrofloxan 500 mg. But i a

I : I would not suggestion you go to work until most of your symtoms are resolved. It sounds like you had pyelonepritis which is a very serious condition. It is not just a urinary tract infection. Get more rest, increase fluid hydration, and you should follow up with your doctor to make sure your urine-analysis is clear and kidney fuction is back to normal. ...Read more

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My husband takes a antibiotic for strep throat. We had sex monday morning and 11:30 pm. He said it stung a little when he urinated. I may have yeast?

My husband takes a antibiotic for strep throat. We had sex monday morning and 11:30 pm. He said it stung a little when he urinated. I may  have yeast?

Not sure.: Unlikely that he has infection. Much more likely that he has irritation which should get better with time. However, although not mentioned specifically i assume he is taking ant rejection meds for his kidney. In that case should watch carefully for further signs that things are not going well. ...Read more

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I am taking 2 antibiotics for gastrointestinal infection. One says no to NSAIDs. Is Tylenol (acetaminophen) PM an NSAID. As exhausted and ill as I am, can't sleep. ?

I am taking 2 antibiotics for gastrointestinal infection.  One says no to NSAIDs. Is Tylenol (acetaminophen) PM an NSAID.  As exhausted and ill as I am, can't sleep. ?

Tylenol (acetaminophen) PM: Is not an NSAID and could probably be used safely, if used in the correct dosage. Please check the bottle. Be careful not to take an excessive amount of Tylenol, (acetaminophen) since it can cause liver problems if used excessively. Otherwise, it is worth a try to help you sleep. Good luck. ...Read more

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U1rnp antibody what does it do?

U1rnp antibody what does it do?

Used for diagnosis: of mixed connective tissue disease (generally scleroderma with lupus overlap and muscle inflammation) for which it is fairly specific (accurate). The action of the antibody is not well characterized and probably less important than its use for diagnostic purpose (we know it binds to a protein for RNA building). In patients with anti-centromere Ab+ scleroderma, it portends kidney complications. ...Read more