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Doctor insights on: Pleomorphic Sarcoma Prognosis

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What is pleomorphic rhabdo sarcoma?

What is pleomorphic rhabdo sarcoma?

Cancer, usually kids: Pleomorphic rhabdomyosarcoma is a rare cancer that occurs primarily in kids and rarely in adults. Chemotherapy is given to all patients followed by surgery and/or radiation, depending on the specific case. If caught before it spreads, it can often be cured.

Dr. Chad Levitt
2 Doctors shared insights

Sarcoma (Definition)

By definition, it is malignant (i.e., being locally invasive and at least theoreticlally capable of metastasizing), and arises from / mimics muscle or connective tissue elements that are not marrow or immune / white cells. The sarcomas are a tremendously varied and troublesome family of tumors, though thankfully less common than carcinomas and the leukemia / ...Read more


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What is the definition or description of: pleomorphic?

What is the definition or description of: pleomorphic?

Many shapes: We use the term pleomorphic often in pathology; it literally means "many shapes". Pleomorphic cells in a tumor may tell of the genetic instability that's central to cancer, but the benign pleomorphic adenoma of the salivary glands merely has many different tissue types. The context gives the meaning.

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What are pleomorphic bacteria, and are they dangerous to humans?

What are pleomorphic bacteria, and are they dangerous to humans?

Change shape: Pleomorphic bacteria are ones that don't always exist in a single, set shape. Their level of danger depends on what they are and their virulence; there is nothing about being pleomorphic itself that makes them dangerous.

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What kind of cancer is a pleomorphic xanthoastrocytoma?

What kind of cancer is a pleomorphic xanthoastrocytoma?

Generally Benign: This is a neoplasm of the brain that generally affects children and teenagers. They are considered generally benign and are classified as grade 2 astrocytomas. They develop from astrocytes which are cells of our brains. They are usually slow growing and often present with sudden onset of seizures due to pressure in the brain. Very rarely do these tumors undergo malignant transformation.

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Hi. I need help. Will you please tell me or explain to me the pathophysiology of pleomorphic adenoma? Thanks

Hi. I need help. Will you please tell me or explain to me the pathophysiology of pleomorphic adenoma? Thanks

Little to it: The anatomic pathology of pleomorphic adenoma is amazingly complex, and we are learning a bit about its molecular biology. The lesions are benign but locally destructive, especially endangering the facial nerve if in the parotid. Wide excision is required as the lesion sends out projections. Around 1% is the site of origin for a real cancer.

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My diag mammo stated presence of a small tightly grouped microcalcifications slightly pleomorphic and represent interval how serious? Going to see BS

My diag mammo stated presence of a small tightly grouped microcalcifications slightly pleomorphic and represent interval how serious? Going to see BS

Mammography: Hi, Pleomorphic Microcalcifications on mammogram are concerning and deserve further evaluation including Ultrasound/MRI and biopsy. please talk to your surgeon. Good luck.

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My mammogram shows clustered pleomorphic calcification should I be worried?

My mammogram shows clustered pleomorphic calcification should I be worried?

Be concerned!: By your description a biopsy would be indicated. This can be performed with ultrasound guidance if there are findings by u/s in the region, or if not, with stereotactic guidance. These can easily be performed by a radiologist skilled in these procedures, or by a breast surgeon. This should be done as soon as possible.

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Fnac shows that smears show pleomorphic salivary adenoma. What is the treatment for this?

Fnac shows that smears show pleomorphic salivary adenoma. What is the treatment for this?

Primary tx: Superficial parotidectomy is the treatment of choice for most benign tumors in the superficial lobe.

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I ve 1.8cm *1.3cm pleomorphic adenoma on superficial lobe of patotid gland. Scared to do surgery. Possible complications of surgery? Postoperative care?

I ve 1.8cm *1.3cm pleomorphic adenoma on superficial lobe of patotid gland. Scared to do surgery. Possible complications of surgery? Postoperative care?

Surgery mandatory: The benign tumor will just get bigger and bigger and the risks of nerve damage will be higher. Procedure safe with an experienced surgeon. Recommend Jeffrey Spiro, M.D., Professor, Department of Surgery. U Conn Medical Center, Framingham CT 860-679-2804

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Suspicious clusters of pleomorphic calcifications found on one breast only during mammogram?

Suspicious clusters of pleomorphic calcifications found on one breast only during mammogram?

Needs biopsy: Suspicious cluster opleomorphic microcalcifications on mgram may be due to breast cancer. Therefore you need to undergo a biopsy. Usually they sggest a stereotactic biopsy which is a type od percutaneous needle biopsy n a special x-ray table. Please follow with a breast carer specialist or a radiologist experien in this procedure.

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I ve pleomorphic adenoma in parotid gland. Dr performed fnac. Does fnac spread tumor cells. Scared. Size is 1.5cm. Entire gland needs removal?

Spread not likely: Pleomorphic adenoma is benign and there is minimal risk of spread with a fine needle aspirate. Removal is warranted as the lesion can become larger.

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If you had a benign pleomorphic adenoma in a minor salivary gland for approx 5 years would you have it surgically removed?

If you had a benign pleomorphic adenoma in a minor salivary gland for approx 5 years would you have it surgically removed?

Yes: These lesions can grow and can undergo malignant transformation. I almost always rec excision. Find an ENT doctor who does frequent parotidectomies with facial nerve dissections.

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Could my son get cancer if he was diagnosed with pleomorphic adenoma, 3 tumors in the neck and 1 in cheek?

Rarely: Pleiomorphic adenomas are benign tumors of saliva glands. It is unusual for them to be in the neck itself, but they can arise "rests" of salivary tissue in the neck. They tend not to spread to other parts of the body but can grow back in the areas where they arose in about 20% of patients who had surgery. Rarely they can turn cancerous and spread to other organs. Best wishes.

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My son was diagnosed with pleomorphic adenoma, 3 tumors in the neck and 1 in cheek. Could this become cancer?

Pleomorphic adenomas: These salivary gland tumors are usually benign. If the tumor is of the mixed type it could become cancerous

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My mum was diagnosed with pleomorphic parotid adenoma and she has a heart condition. Is an operation really necessary? My mum is 79

My mum was diagnosed with pleomorphic parotid adenoma and she has a heart condition. Is an operation really necessary? My mum is 79

An operation: Is generally necessary. Ask your doctor whether or not her medical risks outweigh benefits of surgery, because a lot depends on the severity of her heart condition.

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What do you suggest if my son was diagnosed with pleomorphic adenoma, 3 tumors in the neck and 1 in cheek. Can this turn into cancer?

What do you suggest if my son was diagnosed with pleomorphic adenoma, 3 tumors in the neck and 1 in cheek. Can this turn into cancer?

Early ENTinvolvement: Close follow-up with the ENT, surgical resection is required. Yes, these have a high rate of malignant transformation.

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Had mgram which showed pleomorphic calcs in r breast. Have biopsy in monday. What is rate of cancer assoc with this type? Can they be benign too?

Had mgram which showed pleomorphic calcs in r breast. Have biopsy in monday. What is rate of cancer assoc with this type? Can they be benign too?

Probably benign: There's about a 12% risk these will prove to be malignant. That leaves an 88% chance of benignancy. Good luck with the biopsy - I hope you get good results.

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Internet info states that if breast calc are defined pleomorphic that risk of being malignant goes way up to 1 in 4. Is this true? Have biopsy mon

Internet info states that if breast calc are defined pleomorphic that risk of being malignant goes way up to 1 in 4. Is this true? Have biopsy mon

Relax: Relax until you get your results. Then, have the doctor explain until you understand - or have a close person along to also get the info. Before results there is nothing you can do - so try to stay calm. Afterwards ask for a referral to a supportive therapist to help you through the treatment choices. It can make a big difference in your outcome and adjustment. I hope it goes well for you.

Pleomorphic (Definition)

We use the term pleomorphic often in pathology; it literally means "many shapes". Pleomorphic cells in a tumor may tell of the genetic instability that's central to cancer, but the benign pleomorphic adenoma of the salivary glands merely has many different tissue types. The ...Read more


Prognosis (Definition)

The prognosis is the predicted outcome or "forecast" for a disease or process. It is only an estimate but is likely based on past experience or data taking into account the individual's overall health status. It may suggest progression of disease ...Read more