Doctor insights on:
Pleomorphic Lobular Carcinoma Of The Breast
Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more
What are the causes of breast and arm pain after having biopsy with lobular carcinoma in situ diagnosis?
LCIS : Lobular-carcinoma-in-situ (lcis) is a microscopic finding on breast biopsy that is associated with an increased risk of breast cancer in either breast of those affected. It is silent in that it causes no symptoms. Therefore, your breast & arm pain is unrelated to the diagnosis. Perhaps the pain is related to the biopsy procedure itself. If so, it should resolve pretty quickly. ...Read more
Had mgram which showed pleomorphic calcs in r breast. Have biopsy in monday. What is rate of cancer assoc with this type? Can they be benign too?
Needs investigation: Although breast calcifications may not necessarily mean cancer, pleomorphic calcifications are suspicious. A biopsy should be done. Talk to your doctor. Pleomorphism means that something is of varying shape and characteristics. A non-cancerous or benign calcification will be read as "benign-appearing". Don't delay your biopsy. ...Read moreSee 4 more doctor answers
Biopsy: The only way to make a diagnosis of ilc is by biopsy (usually needle biopsy). The problem with ilc is that it often does not show up on a mammogram or sonogram until it is large or a lump can be felt. That is why the diagnosis of ilc is often made later than other types of breast cancer. ...Read moreSee 1 more doctor answer
Good: Lobular breast cancer is more frequently multifocal and bilateral than ductal carcinoma. However, with mastectomy (lumpectomy may not be sufficient) and sentinel lymph node biopsy, with follow-up hormone therapy and/or radiation should yield a good outcome, depending on the grade and stage of the cancer. Stage is most important, along with hormone receptor status. ...Read moreSee 1 more doctor answer
Also called lobular: Neoplasia...It forecasts that you will develop a breast cancer in either breast. Some used to do "mirror" biopsies. Others contemplate bilateral mastectomy. Lcis is a risk not a cancer, but the lobular invasive cancer can pose detection problems. Discuss this with a breast cancer team. I would watch very carefully. Lobular cancer makes up only 15% of invasive cancer. ...Read more
No: Although both are breast cancers they are different in the significance attached to them. Lobular carcinoma is more likely to be larger, lymph node positive and estrogen positive then invasive ductal. A study in the ann surg oncol. 2010 jul;17(7):1862-9. Epub 2010 feb 17 suggests that invasive lobular carcinoma has a better prognosis stage for stage than invasive ductal carcinoma. ...Read more
Stage-Dependent: Breast cancers are staged based upon the size of the cancer, lymph node or distant organ involvement, direct extension to the skin or chest wall muscles, and unique molecular features of the tumor. Published rates of 5-yr survival (http://www.Cancer.Org/cancer/breastcancer/detailedguide/breast-cancer-survival-by-stage) vary quite a bit based on these variables, between 15%-93%. ...Read moreSee 1 more doctor answer
Yes BUT: We need to consider that this is probably lobular "neoplasia" vs. Cis. That being said we still feel this is marker of increased cancer risk. We shouldn't neglect putting together fam history, other risk factors, limitations & risks in imaging, etc before discounting antihormonal therapy and rarely surgery. Many do choose close follow-up. Natural treatments may be incorporated with sufficient data. ...Read more
I have invasive lobular carcinoma, stage 2b, grade 2, spread to 1 lymph-node. Estrogen + , her2 - should I consider genetic testing?
Yes, please: Breast cancer at age 33 meets criteria for brca testing. The results may significantly impact one's surgical treatment decision (best to do before radiation therapy, since this would be unnecessary if one opts for mastectomy). That said, without any other risk factors, the statistical probability of being brca (+) is not that high. Please see a genetic counselor. ...Read more
What is the survival rate for stage 3 invasive lobular carcinoma? Possibly has been there for 3-4 years undetected.
5 year: survival rate is approximately 70%.Get a more detailed answer ›
Is mastectomy good for an invasive & in situ lobular carcinoma, stage 1b, sbr grade 2, 8 mm in size with good margins except anterior margin 1.5mm ?
Concern: The 1.5mm margin anteriorly is the only margin that gives me concern. For patients undergoing lumpectomy, obtaining at least a 2mm margin is associated with a decreased risk of recurrence. It would not be usual practice to take you back to surgery for a re-excision of this margin, however. ...Read moreSee 1 more doctor answer
The drug is taxotere (docetaxel) and cyclophosphamide used in chemo due to early stage of invasive lobular carcinoma does side effect cause insomia , depression?
Chemo and cancer: Dealing with cancer and its treatment is not something easy to do in many cases. Not only it is affecting your physical condition, emotionally, you can also develop anxiety, depressed mood, depression etc through out the battle. The chemo themselves do not give you insomnia. However, steroids are given prior to chemo, and this can cause insomnia. Depression/anxiety cause insomnia too. ...Read more
Sightly increased...: There is a slightly increased risk of breast cancer with lobular neoplasia, but the majority of women with this diagnosis do not get breast cancer. Some sites describe a 7 to 11 times increased risk for future breast cancer. Tamoxifen may be a consideration for breast cancer prevention. See a breast specialist and consider genetic testing for breast cancer risk analysis. ...Read moreSee 1 more doctor answer
We use the term pleomorphic often in pathology; it literally means "many shapes". Pleomorphic cells in a tumor may tell of the genetic instability that's central to cancer, but the benign pleomorphic adenoma of the salivary glands merely has many different tissue types. The ...Read more
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