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Doctor insights on: Plasminogen Activator Inhibitor 1

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Please explain plasminogen activator.?

Please explain plasminogen activator.?

Clot Buster: Tissue plasminogen activator (tpa (alteplase)) is a chemical that triggers rapid breakdown of blood clots. It is used in stroke patients in an attempt to restore bloodflow to the brain before cells die, but the risk of bleeding makes it safe to use only in very specific circumstances. The most common reason for not qualifying for tpa (alteplase) is not getting to the er quickly enough- don't wait! time is brain! ...Read more

Dr. M. Hytham Beck
12 doctors shared insights

Alteplase (Definition)

Alteplase is a clot buster which is a kind of ...Read more


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A tissue plasminogen activator is what?

A tissue plasminogen activator is what?

Fibrinolytic: Tissue plasminogen activator (tpa) is a serine protease (enzyme) that catalyzes the reaction that converts plasminogen to plasmin. Plasmin is responsible for breaking down blood clots by cleaving molecules of fibrin, creating "fibrin degradation products". ...Read more

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Caring for an Elderly Loved One (Checklist)

Check your loved one's balance
once
Remove obstructions that could cause falls
once
Organize medications
monthly
Add railings for support
once
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Please explain plasminogen activator.?

Clot Buster: Tissue plasminogen activator (tpa (alteplase)) is a chemical that triggers rapid breakdown of blood clots. It is used in stroke patients in an attempt to restore bloodflow to the brain before cells die, but the risk of bleeding makes it safe to use only in very specific circumstances. The most common reason for not qualifying for tpa (alteplase) is not getting to the er quickly enough- don't wait! time is brain! ...Read more

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What are tissue plasminogen activators used for?

What are tissue plasminogen activators used for?

Dissolve blood clots: These are proteins that when added to blood bind to clots and dissolve them. ...Read more

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Living with Type 1 Diabetes (Checklist)

Hypoglycemia is common with type 1 diabetes
once
Check your blood glucose before and after 2 hours after eating
once
Hypoglycemia is likely if the post meal glucose is lower than premeal
once
If you do not feel hypo symptoms, consider use of a continuous sensor
once
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Got superficial blood clots in left arm with no cause again. Coagulation panel showed high plasminogen. What does that mean?

Got superficial blood clots in left arm with no cause again. Coagulation panel showed high plasminogen. What does that mean?

Too much plasminogen: Your high plasminogen likely causes, or is related to, your clotting problem. See an explanation of your rare disorder on this website (cut and paste into web browser): http://www.chla.org/site/c.ipINKTOAJsG/b.7717791/k.A1D0/Disorders_of_Fibrinolysis__Bleeding_Disorder__Plasminogen.htm#.VAhd29m9LCQ Talk to a hematologist for more understanding. Best wishes! ...Read more

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Will taking activated charcoal for bloating while you are on Alli (orlistat lipase inhibitor) decrease or counteract the effectiveness of Alli?

Will taking activated charcoal for bloating while you are on Alli (orlistat lipase inhibitor) decrease or counteract the effectiveness of Alli?

Activated Charcoal: Activated Charcoal is often given in cases of poisoning or overdoses. This is because it absorbs whatever might be in the stomach before the substance reaches the small intestine where it gets absorbed into the bloodstream. Taking the charcoal within an hour or two of Orlistat will likely reduce it's effectiveness. Try to space the charcoal dose 3 hours between each Orlistat dose. ...Read more

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Azd 6244- mek inhibitor- a selective mitogen-activated protein kinase (mek) inhibitor. Mk 2206- akt inhibitor. Why prescription for me? It ? Nsclc/mets

Azd 6244- mek inhibitor- a selective mitogen-activated protein kinase (mek) inhibitor.    Mk 2206-  akt inhibitor.  Why  prescription for me? It ? Nsclc/mets

Molecular targeting: These agents are designed to selectively knock out key pathways your tumor may use to grow. Presumably you already had your tumor tested for these different mutations. Ask the doctor offering these options to explain their rationale. These are investigational studies and many of the treatment costs may be covered-ask. ...Read more

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C1 Esterase Inhibitor Panel had two functional and one protein level. The protein level was 11 (20-40 ml/dL). What does that mean? Other two normal.

C1 Esterase Inhibitor Panel had two functional and one protein level. The protein level was 11 (20-40 ml/dL). What does that mean? Other two normal.

Makes no sense: C1INH assays may show low C1INH (which you appears to have) or normal C1INH level with impaired functioning if you are looking for the typical cases of hereditary edema. If the quantity is low, there cannot be normal functioning. If you do have HAE, treatment should be started promptly to prevent throat swelling. ...Read more

Dr. Brian Santin
69 doctors shared insights

Clot Buster (Definition)

Clot busters are a kind of ...Read more