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Doctor insights on: Plasminogen Activator Inhibitor 1

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Please explain plasminogen activator.?

Please explain plasminogen activator.?

Clot Buster: Tissue plasminogen activator (tpa (alteplase)) is a chemical that triggers rapid breakdown of blood clots. It is used in stroke patients in an attempt to restore bloodflow to the brain before cells die, but the risk of bleeding makes it safe to use only in very specific circumstances. The most common reason for not qualifying for tpa (alteplase) is not getting to the er quickly enough- don't wait! time is brain! ...Read more

Dr. James Dukelow
12 doctors shared insights

Alteplase (Definition)

Alteplase is a clot buster which is a kind of ...Read more


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A tissue plasminogen activator is what?

A tissue plasminogen activator is what?

Fibrinolytic: Tissue plasminogen activator (tpa) is a serine protease (enzyme) that catalyzes the reaction that converts plasminogen to plasmin. Plasmin is responsible for breaking down blood clots by cleaving molecules of fibrin, creating "fibrin degradation products". ...Read more

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Caring for an Elderly Loved One (Checklist)

Check your loved one's balance
once
Remove obstructions that could cause falls
once
Organize medications
monthly
Add railings for support
once
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Please explain plasminogen activator.?

Clot Buster: Tissue plasminogen activator (tpa (alteplase)) is a chemical that triggers rapid breakdown of blood clots. It is used in stroke patients in an attempt to restore bloodflow to the brain before cells die, but the risk of bleeding makes it safe to use only in very specific circumstances. The most common reason for not qualifying for tpa (alteplase) is not getting to the er quickly enough- don't wait! time is brain! ...Read more

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What are the differences between recombinant tissue plasminogen activator and tissue plasminogen activator?

What are the differences between recombinant tissue plasminogen activator and tissue plasminogen activator?

Same aa sequence: tPA and its recombinant version (Activase) are identical with respect to the amino acid sequence. There have been reported some minor differences with respect to glycosylation of the protein, but this is well within the specifications of the cGMP production by the manufacturer. ...Read more

Dr. Jeffrey Unger Dr. Unger
<b>2</b> doctors agreed:
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Living with Type 1 Diabetes (Checklist)

Hypoglycemia is common with type 1 diabetes
once
Check your blood glucose before and after 2 hours after eating
once
Hypoglycemia is likely if the post meal glucose is lower than premeal
once
If you do not feel hypo symptoms, consider use of a continuous sensor
once
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What are tissue plasminogen activators used for?

What are tissue plasminogen activators used for?

Dissolve blood clots: These are proteins that when added to blood bind to clots and dissolve them. ...Read more

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Got superficial blood clots in left arm with no cause again. Coagulation panel showed high plasminogen. What does that mean?

Got superficial blood clots in left arm with no cause again. Coagulation panel showed high plasminogen. What does that mean?

Too much plasminogen: Your high plasminogen likely causes, or is related to, your clotting problem. See an explanation of your rare disorder on this website (cut and paste into web browser): http://www.chla.org/site/c.ipINKTOAJsG/b.7717791/k.A1D0/Disorders_of_Fibrinolysis__Bleeding_Disorder__Plasminogen.htm#.VAhd29m9LCQ Talk to a hematologist for more understanding. Best wishes! ...Read more

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Will taking activated charcoal for bloating while you are on Alli (orlistat lipase inhibitor) decrease or counteract the effectiveness of Alli?

Will taking activated charcoal for bloating while you are on Alli (orlistat lipase inhibitor) decrease or counteract the effectiveness of Alli?

Activated Charcoal: Activated Charcoal is often given in cases of poisoning or overdoses. This is because it absorbs whatever might be in the stomach before the substance reaches the small intestine where it gets absorbed into the bloodstream. Taking the charcoal within an hour or two of Orlistat will likely reduce it's effectiveness. Try to space the charcoal dose 3 hours between each Orlistat dose. ...Read more

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Azd 6244- mek inhibitor- a selective mitogen-activated protein kinase (mek) inhibitor. Mk 2206- akt inhibitor. Why prescription for me? It ? Nsclc/mets

Azd 6244- mek inhibitor- a selective mitogen-activated protein kinase (mek) inhibitor.    Mk 2206-  akt inhibitor.  Why  prescription for me? It ? Nsclc/mets

Molecular targeting: These agents are designed to selectively knock out key pathways your tumor may use to grow. Presumably you already had your tumor tested for these different mutations. Ask the doctor offering these options to explain their rationale. These are investigational studies and many of the treatment costs may be covered-ask. ...Read more

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C1 Esterase Inhibitor Panel had two functional and one protein level. The protein level was 11 (20-40 ml/dL). What does that mean? Other two normal.

C1 Esterase Inhibitor Panel had two functional and one protein level. The protein level was 11 (20-40 ml/dL). What does that mean? Other two normal.

Makes no sense: C1INH assays may show low C1INH (which you appears to have) or normal C1INH level with impaired functioning if you are looking for the typical cases of hereditary edema. If the quantity is low, there cannot be normal functioning. If you do have HAE, treatment should be started promptly to prevent throat swelling. ...Read more

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One of symptom of CHF is cough, can ACE inhibitors be used as it also causes cough.

One of symptom of CHF is cough, can ACE inhibitors be used as it also causes cough.

Yes: Cough due to CHF is due to excessive fluid buildup in lungs due to inefficient heart function. Cough due to ace inhibitors is a benign (though irritating) side effect seen in a minority of patients. Ace inhibitors are first line drugs for "systolic" CHF ( due to weakened heart muscle). Presence of cough does not exclude use, but most physicians would switch to alternative "arb" medication. ...Read more

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New study links proton pump inhibitors with dementia. But this is just one study. How much validity is there to this conclusion?

New study links proton pump inhibitors with dementia. But this is just one study. How much validity is there to this conclusion?

Enough to be alert: Excellent question for new findings on a commonly used medical class. Were you aware that men show increase in hip fractures as well? Sometimes it is only after a new drug has been used on many many people over time that we find new problems that did not show up in original tastings. The real question is why you are using it, and is there a safer alternative? Then you can determine relative risk ...Read more

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Can some one tell me the best serotonin reuptake inhibitor to use for sadness?

Can some one tell me the best serotonin reuptake inhibitor to use for sadness?

Like perfume: There is no best without considering personal context. Also, there may be quite a few that will work for any given patient. Your insurance company will prefer you start with lowest price product. Like perfume, if you like the effect, then it is best for you. Potential for drug-drug interaction can also be a consideration, but that is a complex analysis that you need to figure out with your doctor. ...Read more

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Can an ace-inhibitor 20 mg. Tab be cut in half and taken twice daily, instead of one time, since it reduces (it's working) side effects in a patient?

Can an ace-inhibitor 20 mg. Tab be cut in half and taken twice daily, instead of one time, since it reduces (it's working) side effects in a patient?

Depends: I agree that twice daily dosing in clinical trials has somewhat better effects on the neuroendocrine system, however many pills are not safe to split--especially extended release formulations. It depends on the manufacturer. Aceon, mavik, (trandolapril) and univasc may be splittable ace inhibitors if you are trying to save money, but please consult your doctor first! don't split non-scored pills! ...Read more

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Could you tell me what happens if a person who is not actually having a stroke is given tpa (alteplase)?

Could you tell me what happens if a person who is not actually having a stroke is given tpa (alteplase)?

Increased bleed risk: Tissue plasminogen activator, or tpa, (alteplase) "dissolves" clots, so the main risk from it's administration is an increased risk of bleeding. One way to reduce the risk is to have strict rules on who it is administered to, based on many factors including time since symptoms began. Another is to administer it right where it is needed, near the location of the artery which contains the clot. ...Read more

Dr. Brian Santin
71 doctors shared insights

Clot Buster (Definition)

Clot busters are a kind of ...Read more