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Doctor insights on: Plasminogen Activator Inhib Pai 1

Clot Buster: Tissue plasminogen activator (tpa (alteplase)) is a chemical that triggers rapid breakdown of blood clots. It is used in stroke patients in an attempt to restore bloodflow to the brain before cells die, but the risk of bleeding makes it safe to use only in very specific circumstances. The most common reason for not qualifying for tpa (alteplase) is not getting to the er quickly enough- don't wait! time is brain! ...Read more

Fibrinolytic: Tissue plasminogen activator (tpa) is a serine protease (enzyme) that catalyzes the reaction that converts plasminogen to plasmin. Plasmin is responsible for breaking down blood clots by cleaving molecules of fibrin, creating "fibrin degradation products". ...Read more

Dissolve blood clots: These are proteins that when added to blood bind to clots and dissolve them. ...Read more

Too much plasminogen: Your high plasminogen likely causes, or is related to, your clotting problem. See an explanation of your rare disorder on this website (cut and paste into web browser): http://www.chla.org/site/c.ipINKTOAJsG/b.7717791/k.A1D0/Disorders_of_Fibrinolysis__Bleeding_Disorder__Plasminogen.htm#.VAhd29m9LCQ Talk to a hematologist for more understanding. Best wishes! ...Read more

Gradient: The older one gets, the greater the risk of intracerebral hemorrhage. Especially after age 75 risk escalates. Then this turns on risk-benefit estimation. ...Read more

Used to be rigid: Used to be arbitrary age which i believe was 75 and now is individualized. ...Read more

TPA (alteplase): Tpa (alteplase) or tissue plasminogen activator is a subtance that is used to break up clots that form in the body. It has been used to stop heart attacks, strokes or clots that form in the arms or legs. It has even been used to dissolve clots in the lungs with some success. ...Read more

Complicated : You need to check it with your physician since it depends on many parameters , but generally speaking: head ct, blood pressure, age, time onset of stroke, coagulant estate and use of anticoagulation, history of previous stroke, bleeding and recent surgeries.... ...Read more

Increased bleed risk: Tissue plasminogen activator, or tpa, (alteplase) "dissolves" clots, so the main risk from it's administration is an increased risk of bleeding. One way to reduce the risk is to have strict rules on who it is administered to, based on many factors including time since symptoms began. Another is to administer it right where it is needed, near the location of the artery which contains the clot. ...Read more

Question: So if you didn't have a stroke what improved when you got the TPA (alteplase)? ...Read more