Doctor insights on:
Plasma Cells In Bone Marrow Biopsy
Can be normal.: Up to 5% is normal as long as they are not "monoclonal" meaning derived from a cell. If monoclonal then a bone cancer called myeloma needs to be ruled out. If no bone disease, anemia, high calcium or kidney disease answer is MGUS, a pre-cancerous condition with low risk of progression (less than 1% per year). ...Read more
A bone marrow biopsy is taken from the pelvic bone. A coring needle is advanced into the bone, which allows one to extract a sliver of the bone marrow, the red part of the bone. It is cut and viewed under a microscope. A bone marrow aspirate, obtained with a syringe, is usually bone at the same time. These are done to diagnose blood problems or to check for tumors in ...Read more
Stem cells: There are many types of stem cells that reside in the bone marrow. They technically aren't "embryonic" stem cells, since those by definition are derived from an embryo. The stem cells that exist in your bone marrow, however, share many of the characteristics of embryonic stem cells. ...Read more
Why are umbilical cord stem cells sometimes uses along with donor cells in an allogeneic bone marrow transplant?
One of the other: Stem cells can be obtained from 3 different sources: from Bone marrow of the Donor, blood of the donor or stem cells from umbilical cord. But we have to give an adequate number(Dose) of stem cells in order to have full protection. So combining them may only be needed because of inadequate number of stem cells from one of the sources ...Read more
Abnormal result: 15% plasma cells is abnormally high. This may be due to several different causes. Sometimes it may be due to an acute infection, or another illness in the body. A more serious cause is Multiple Myeloma. There is also Asymptomatic Multiple Myeloma in which the patient has: normal x-rays, red blood count, blood calcium and kidney function. Only some of these will develop Multiple Myeloma. ...Read more
Who is donor?: This depends--if it is an autologous transplant where a patient receives their own cells then the immune system and blood type are unchanged. An allogeneic transplant comes from donor different than the patient. In this case the immune system changes. Also, if the donor has a different red cell type then the recipient's blood type will change too. ...Read moreSee 1 more doctor answer
Yes: Mostly hematopoietic (blood) cells and a few mesenchymal (mscs) can be obtained from bone marrow aspiration. Trends in most non-blood applications is to use fat tissues, which have many more mscs that bone marrow. Choice of which depends on specific conditions being treated. ...Read moreSee 1 more doctor answer
Pls hematologist opinion blast cells less than 1 percent but 14 percent plasma cells in bone marrow aspiration means?
Difficult to tell.: From my reading, a blast percentage of 6% is needed for a sure diagnosis of acute leukemia. Toxins, allergies, infections, diabetes, liver disease, inflammation, and anemias can all cause a leukeamoid reaction that causes plasmacytosis in the bone marrow usually lower than 20% but sometimes up to 50%. Immunohistological studies can give more information. Need more info like blood cell counts. ...Read moreSee 1 more doctor answer
There is big differe: Bone marrow biopsy is done to obtain a pice of tissue to look under the microscope and find out if the blood formation is normal or abnormal. Chromosomes are not visible in the standard bone marrow biopsy. For this we need to culture the blood cells and capture the chromosomes when they are well formed just before the cells divide. This test takes a laboratory which can culture blood cells to see. ...Read more
Complex question: It's not just the number, but how they crowd out normal cells, and how much other problems they cause (elevated calcium, sludging, infiltration of bone, etc.) would probably need a special online consult to sort this out better. Without an actual examination, I cannot give specific medical advice on your particular health, ...Read more
Check : With your arrow bank about their qualifications ...Read more
How does one differentiate between infection n malignancy in the bone marrow plasma cell percentage?
Monoclonal or not: Malignant plasma cells are monoclonal in that they are copies of each other and produce the same antibody. This antibody can be identified in urine or blood tests in malignancy. Increased plasma cells due to infection are polyclonal (not copies of each other) and produce non-identical antibodies. ...Read more
Large chunk of skin: A chunk of skin must have been sent along with the bone fragment from the biopsy. Squamous epithelium is the skin cell type found in the outer layer of skin (& on contiguous surfaces like the inside of your mouth). It looks distinct under the microscope. In some cases, squamous cell cancer can invade the bone marrow, but I doubt that it is your case because the cells were detached, not mixed in. ...Read more
Biopsy is tissue removed by needle or cutting to remove part of a body part. It is usually a small amount of material that is processed by a pathologist. Most of the time it is stained and looked at through a microscope to arrive at a diagnosis. Special processes are done for some tissues or problems. The purpose is to tell what the problem is (diagnosis). ...Read more
Bone marrow is the flexible tissue found in the interior of bones. In humans, red blood cells are produced in the heads of long bones, in a process known as hematopoesis. On average, bone marrow constitutes 4% of the total body mass of humans; in an adult weighing 65 kilograms (140 lb), bone marrow accounts for approximately ...Read more
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