Doctor insights on:
Plasma Cells In Bone Marrow Biopsy
Can be normal.: Up to 5% is normal as long as they are not "monoclonal" meaning derived from a cell. If monoclonal then a bone cancer called myeloma needs to be ruled out. If no bone disease, anemia, high calcium or kidney disease answer is MGUS, a pre-cancerous condition with low risk of progression (less than 1% per year). ...Read more
A bone marrow biopsy is taken from the pelvic bone. A coring needle is advanced into the bone, which allows one to extract a sliver of the bone marrow, the red part of the bone. It is cut and viewed under a microscope. A bone marrow aspirate, obtained with a syringe, is usually bone at the same time. These are done to diagnose blood problems or to check for tumors in ...Read more
Multiple myloma specialist needed pls help me confusing reports low m spike below 1 no crab but 14 percent plasma cells in Bone marrow biopsy worried?
Might be myeloma: Your plasma cells >10% in the bone marrow biopsy mean either smoldering myeloma or active myeloma. If you have elevated calcium, anemia, renal insufficiency or lytic bone lesions, I'm sorry to say you have myeloma. If not, you have smoldering myeloma. Go to this link for more info: http://www. Nccn. Org/patients/guidelines/myeloma/index. Html ...Read more
Non-itchy/raised brown spots on back, spread to chest & stomach. Biopsy shows overproduction of plasma cells; bone marrow biopsy normal. Next steps?
Characterize cells: What you report is not definitive. Is this a plasma cell-rich inflammatory process, or is it a multifocal plasma cell tumor? The pathologists can investigate the cells to determine if they are of mixed clonal origin (benign) or monoclonal (meaning all derived form a single parent, usually a sign of a cancer). This can be done by evaluating the surface light chain expression. ...Read more
Plasma Cells: Plasma cells are a normal component of bone marrow. A higher percentage than normal can indicate certain conditions such as multiple myeloma or MGUS. It is important to understand that any test needs to be interpreted in the context of other clinical findings. Discuss these results with your physician to figure out the diagnosis. ...Read more
Wat does cd 5;21;23 b cell lymphocyte present in bone marrow biopsy indicate. I have pancytopenia nd spleenohepatomegaly?
Not really: Presence of cancer cells is only indication of cancer no other cells., to call it a cancer you have to see cancer cells nothing else. Cd-8 t cells are seen in viral infections also. These cells are some times seen surrounding the tumor or inside the tumor which is a good prognostic sign presence of immunity, body is fighting the cancer. ...Read more
Bone marrow biopsy?:
I am not clear what you are asking--do you want to know how much bone marrow is removed during a bone marrow biopsy?
Generally, 5-15 cc's of marrow is removed during a bone marrow aspiration and then a 2-3 cm small piece of the bone marrow is removed for the biopsy.
If you were trying to get other information please add a more detailed question. ...Read more
Change in components: A bone marrow biopsy in a normal person will find the pattern of cells most often seen in a healthy person of that age. This would include red cells and their precursers (builders), white cells & precursers, platelet precursers & others. In illness, the pattern changes, and some or all may be abnormal. Tumor cells may take over every space& or few if any normal cells may be seen. ...Read more
Many Indications: Bone marrow biopsy is most useful in diagnosis and staging of blood cancers (leukemia, lymphoma, multiple myeloma, etc). Also indicated for evaluating unexplained anemia, leukopenia, thrombocytopenia, pancytopenia, or unexplained elevated blood counts. It is also useful for fever of unknown origin, or as a confirmation that bone marrow transplantation is successful. ...Read more
Depends: If your receive conscious sedation, you will not have noticeable pain during the procedure. Afterward, you may have pain for a day or so unless there is an untoward complication. I had one and it hurt minimally for 24 hours. I had conscious sedation. ...Read more
Sedation: Light sedation can be used, in addition the soft tissues should be numbed to the periosteum, the outer layer of bone. ...Read more
Clarify your questio: In what setting? It depends on what disease, how long you have that, do you have systemic symptoms etc? For more indolent disease - like cll for instance- the chance to see involvement to the bone marrow is pretty high as the disease may have been there for years. For acute leukemia- definitely bone marrow will be abnormal. ...Read more
Short term: Should be no more than a few days; and that is on the longer side of the estimate. ...Read more
Not long: See my previous answer. Usually a day or so unless there were complications. If longer than a couple of day, I would call the doctor and discuss. There could be bleeding at the site with a hematoma or potentially an infection. A bruise is to be expected and can cause some soreness. ...Read more
Needle biopsy.: A bone marrow biopsy is taken from the pelvic bone. A coring needle is advanced into the bone, which allows one to extract a sliver of the bone marrow, the red part of the bone. It is cut and viewed under a microscope. A bone marrow aspirate, obtained with a syringe, is usually bone at the same time. These are done to diagnose blood problems or to check for tumors in people with known cancer. ...Read more
A few weeks usually: Normally- you may feel some tenderness for a week or more after your bone marrow exam. Ask your doctor about taking a pain reliever, such as Acetaminophen (tylenol, others). Some people have pain that will last longer. If you are getting more and more pain then have it checked out. ...Read more
Biopsy is tissue removed by needle or cutting to remove part of a body part. It is usually a small amount of material that is processed by a pathologist. Most of the time it is stained and looked at through a microscope to arrive at a diagnosis. Special processes are done for some tissues or problems. The purpose is to tell what the problem is (diagnosis). ...Read more
Bone marrow is the flexible tissue found in the interior of bones. In humans, red blood cells are produced in the heads of long bones, in a process known as hematopoesis. On average, bone marrow constitutes 4% of the total body mass of humans; in an adult weighing 65 kilograms (140 lb), bone marrow accounts for approximately ...Read more
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