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Doctor insights on: Plaquenil Skin Rash

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I have recurring flares of rashes, joint pain, muscle aches, debilitating fatigue, dizziness. I have photosensitity and one episode of my WBC at 2.0 years back. My ANA is 6:40. I'm on plaquenil. Why are all my other antibodies neg for lupus?

I have  recurring flares of  rashes, joint pain, muscle aches, debilitating fatigue, dizziness. I have photosensitity and one episode of my WBC at 2.0 years back.  My ANA is 6:40.  I'm on plaquenil. Why are all my other antibodies neg for lupus?

Maybe SLE maybe not.: Diagnosis of rheumatologic disease is generally based on symptoms with support from lab. Sounds like you have a rheumatologic disease and are being treated with a rheumatologic agent perhaps by a rheumatologist. They can explain your particular situation better, but suffice it to say tests are not always right and a single test does not generally make or break a diagnosis. ...Read more

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Dr. Cornelia Franz
1,059 doctors shared insights

Rash (Definition)

Most bumps and blotches on a newborn baby are harmless and clear up by themselves. By far the most common skin problem in infants is diaper rash. Diaper rash is an irritation of the skin caused by dampness, urine, or feces. Most babies who wear diapers will have some type of diaper rash. However, there are other skin disorders that can cause rashes. These are usually not serious unless ...Read more


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Plaquenil (hydroxychloroquine) has brought ANA, SED, C-Reactive down. I function-barely. I have more energy than before but still have brain fog, rashes, fatigue. Why?

Plaquenil (hydroxychloroquine) has brought ANA, SED, C-Reactive down. I function-barely. I have more energy than before but still have brain fog, rashes, fatigue. Why?

Lupus?: If the Plaquenil (hydroxychloroquine) was given to treat Lupus, 200mg dose, twice a day, does not always shut the condition down 100%. The symptoms listed could be signs that the Lupus is still active. Other medicines may need to be added, such as Prednisone, Methotrexate, or Cytoxan. Side effects and benefits of these meds should be discussed with your Rheumatologist, or other MD who prescribed the Plaquenil (hydroxychloroquine). ...Read more

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Taking 400 plaquenil (hydroxychloroquine). Homogeneous ANA, CH50, compliment 4 still elevated. Inflamed sinuses, fatigue, pericarditis ,rashes. What illness indicated?

Taking 400 plaquenil (hydroxychloroquine). Homogeneous  ANA, CH50, compliment 4 still elevated. Inflamed sinuses, fatigue, pericarditis ,rashes.  What illness indicated?

Lupus: Systemic lupus is most likely although chronic sinusitis is a component of Wegeners. If all of these issues are active then Plaquenil (hydroxychloroquine) is not effective as the only therapy. Options need to be discussed with your rheumatologist. ...Read more

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Ana 1:640x10yrs, other labs neg. Flares of rashes, fatigue, arthralgia, myalgia, dizziness.Crp & sed normal during flares!tx: plaquenil (hydroxychloroquine) & low doses pred prn. Dx?

Ana 1:640x10yrs, other labs neg. Flares of rashes, fatigue, arthralgia, myalgia, dizziness.Crp & sed normal during flares!tx: plaquenil (hydroxychloroquine) & low doses pred prn. Dx?

Fibromyalgia : This all could be related to your fibromyalgia. The positive ANA could due to something else. Most people with a positive ANA do not have lupus or any other inflammatory joint disease. ...Read more

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My dr won't diagnose me, but my joint pain/stiffness, fatigue, dry eyes/mouth, rashes, raynauds & rashes improve on plaquenil (hydroxychloroquine). What does that mean?

Autoimmune disease: You probably have an autoimmune disease that does not meet criteria fully for diagnosis. With time, criteria may be met and a diagnosis may br given. If you are getting better with treatment, then a formal diagnosis is not critical. ...Read more

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I have recurring flares of rashes, joint pain, muscle aches, debilitating fatigue, dizziness. I have photosensitity and one episode of my WBC at 2.0 years back. My ANA is 6:40. I'm on plaquenil. Why are all my other antibodies neg for lupus?

Maybe SLE maybe not.: Diagnosis of rheumatologic disease is generally based on symptoms with support from lab. Sounds like you have a rheumatologic disease and are being treated with a rheumatologic agent perhaps by a rheumatologist. They can explain your particular situation better, but suffice it to say tests are not always right and a single test does not generally make or break a diagnosis. ...Read more

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My lupus flares are Skin manifestation only(malar rash)plus fatigue.But ESR n CRP keeps coming Normal including ANA.on plaquenil (hydroxychloroquine). Was dx not correct?

My lupus flares are Skin manifestation only(malar rash)plus fatigue.But ESR n CRP keeps coming Normal including ANA.on plaquenil (hydroxychloroquine). Was dx not correct?

Maybe, maybe not...: You may have a type of lupus called subacute cutaneous lupus erythematosus(SCLE)which can often be a milder form of systemic lupus(SLE) and can be seen with normal inflammatory markers (ESR).Can also be Sjogren's. However,half of people with SCLE also meet criteria for full blown SLE. SCLE patients can have more serious organ involvement than just skin that should be checked for.See rheumatologist ...Read more

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Dr. John Chiu
2,559 doctors shared insights

Skin Rash (Definition)

A skin rash is a symptom in which a person has changes on part or all of his skin, such as color changes, bumps, blisters, oozing, peeling, ...Read more


Dr. Daniel Saurborn
171 doctors shared insights

Hydroxychloroquine Sulfate (Definition)

Hydroxychloroquine sulfate is an addiction reducing agent which is a ...Read more