Doctor insights on:
Plaquenil Effect Urine
I'm only 35 and can't hold in my urine. I'm on plaquenil, amitiza, (lubiprostone) meloxicam and myfortic. Can any of these be the cause of my incontinence?
Urine is the product of the kidneys, which is produced to eliminate the waste products of metabolism, manage body fluid balance, &maintain acid-base balance. The blood is first filtered by the kidneys, and the composition of the resulting fluid is then altered depending on the body's needs. It is composed of mostly water, and breakdown products from blood cells impart ...Read more
Sle pt w/ flare in july. Hosp. Had dark brown urine but dr said kidneys ok. Recently GFR is 43. Could this be from plaquenil/cellcept/pred or lupus?
See Nephrologist: Early detection and treatment of sle kidney is very important to prevent damage to the kidneys. Creatinine may be normal at certain stages/ types of kidney disease in sle. It is best to be evaluated by a nephrologist.
Nothing safer: Plaquenil is also known as hydroxychloroquine, so the parent drug Chloroquine can be substituted. But Chloroquine has significantly higher rate of retinal toxicity, so it isn't used much anymore. Also, Plaquenil appears to effectively reduce flares in patients with lupus not necessarily by suppressing immunity. So other meds like Imuran and CellCept (mycophenolate mofetil) also reduce flares, but also increases infection.
Yes: At least 100% of my lupus patients have tried it and 75% of the RA patients.
For what treatment?: Plaquenil (hydroxychloroquine) or Hydroxychloroquine is used to treat multiple different conditions. What would be appropriate to substitute would depend on how it is being used to treat your disease.
Plaquenil (hydroxychloroquine): Plaquenil (hydroxychloroquine) has many side effects. Some common ones include dizziness, abdominal pain, headache, nausea, diarrhea, itching, and sensitiviy to sun. More serious side effects which are more rare include certain types of anemia, muscle pain, and liver problems, among others. Despite the fact that what you describe is not officially under it's side effect profile, it still could be causing your symptoms.
Weeks to months: It take weeks to months to clear completely.
Long time: Plaquenil (hydroxychloroquine) takes a long time to get out of the system - up to 18 months. Be certain you and your physician agree you should discontinue it.
Ok...: That an be an appropriate treatment - how are you doing? If you are still suffering, talk to your rheumatologist about your symptoms and explore other options.See 2 more doctor answers
Yes.: No issue with both together.Get a more detailed answer ›
Side effects:: Studies at the cleveland clinic and albany medical college clearly demonstrate that ocular toxicity with ho-q is based solely on getting more the recommended 6mg/kg of body weight. I have never seen ocular toxicity in 1000's of patient I have treated. The most common complaint is queasiness of the stomach when starting it. There are other side-effects, but I've never seen them.