Doctor insights on:
Pitressin Synthetic Medication
Depends on Diagnosis: Pitressin, or vasopressin, is a potent man-made form of a hormone called "anti-diuretic hormone" that is normally secreted by the pituitary gland. In the body, vasopressin acts on the kidneys and blood vessels. It is rarely used except in diabetes insipidus, or during some surgical procedures. There are many contraindications to its use so you should discuss this with your physician in detail. ...Read more
Holds onto water: The posterior (back) part of the pituitary gland in the brain contains the cells that produce oxytocin (that stimulates uterine contractions in labor) and ADH (anti-diuretic hormone), which regulates retention of water by the body. ADH is also called vasopressin because it makes some blood vessels constrict (tighten). ...Read more
What happens if you were stranded in the desert, would you expect your body's production of vasopressin to increase?
Bingo!: Yes, correct. The regulation of vasopressin (ADH) involves both sensors for volume (an extrinsic variable) and solute concentration of blood (an intrinsic variable). As you sweat and lose more water than salt, your blood concentration of solute (called osmolality or osm) goes up...a potent stimulator of ADH secretion. This happens to the person in the desert to conserve water (endocrine regulation ...Read more
Vasopressin,: also known as antidiuretic hormone/ADH, is a "pituitary" hormone which acts to retain water and constrict blood vessels. It increases water reabsorption in the kidney's collecting ducts. Decreased release due to alcohol intoxication or tumor leads to increased blood sodium/excessive urination/thirst. Excess vasopressin leads to low sodium. A number of problems cause inappropriate ADH-tumors, drugs ...Read moreSee 1 more doctor answer
Low sodium: ADH (vasopressin) is anti-diuretic hormone which causes your body to retain free water. When you have too much of it, your body retains too much free water and "dilutes" out the sodium content in your blood which will cause the level to drop. Low sodium in the blood can be very detrimental to your health. ...Read moreSee 1 more doctor answer
Seek Med help if OD: Dear htreference, An OD of ADH can result in excess water retention that can cause electrolyte abnormalities, especially low sodium (hyponatremia) that can be dangerous. Symptoms of too much ADH can include, but not limited to headache, drowsiness, weakness, pale skin, nausea, and stomach pain. A good resource to consider for questions-https://www.poisonhelp.hrsa.gov/the-poison-help-line/ ...Read more
Genetics: Inborn differences among individuals results in a broad range of every type of human characteristic. Hormone production/responsiveness is no different. Some have more; some have less; if it's a lot less, it is viewed as a "deficiency". There may be additional factors -- related to sleep habits, stress, meds, intake of alcohol & other food/beverages, etc., but genetics is probably the main factor. ...Read more
As a protein: Dissolved in the blood.Get a more detailed answer ›
ADH (vasopressin) & Oxytocin: Both are produced in hypothalamus and stored in the posterior pituitary gland. ...Read more
ADH (vasopressin): Adderall (dextroamphetamine and racemic amphetamine) 10 (4 reports): more effective for people 40-49 years old Adderall (dextroamphetamine and racemic amphetamine) 30 (3 reports): more effective for females 20-29 years old Adderall (dextroamphetamine and racemic amphetamine) 5 (4 reports): more effective for males 20-29 years old concerta (4 reports): more effective for females 10-19 years old vyvanse (10 reports): more effective for females 20-29 years old. ...Read more
Not a clear answer: From amini and schmidt, who looked at ADH (vasopressin) secretion after spine surgery, "the mechanism by which CNS disorders cause SIADH (vasopressin) is not well understood. Most authors hypothesize that injury to the CNS disrupts or alters the osmoregulation of ADH (vasopressin) release by the neurohypophysis, stimulating inappropriate release of adh (vasopressin).". ...Read more
Yes & no: Hi. DDAVP (desmopressin) is all we use for central diabetes insipidus (DI), but other non-ADH-analog agents are in all the old literature: chlorpropamide, carbamazepine, and hydrochorothiazide. I've never used any of them for DI. DDAVP (desmopressin) is so effective! Good luck with your hypopituitarism! ...Read more
Pituitary: Hi. ADH (vasopressin) & oxytocin are made in neurons in the hypothalamus and travel down the axons in the pituitary stalk to the posterior pituitary where they are stored until they're released. They're referred to as "posterior pituitary hormones", but they're made in the hypothalamus and only stored and released from the posterior pituitary. ...Read more
Kidney and water: Hi. ADH (vasopressin) prevents the kidney from putting water out in the urine (a graded dose-response). If solutes in the blood are becoming too high a concentration, ADH (vasopressin) is secreted and makes the kidney put water from the kidney filtrate back into the blood, which dilutes out the solutes and brings down the osmolarity. Falling osmolarity suppresses ADH (vasopressin) secretion. The waltz goes on. ...Read more
What hormone inhibits the secretion of adh (vasopressin)? And what situations override the release of this inhibiting hormone?
ADH (vasopressin) secretion: ADH (vasopressin) is mostly controlled by plasma osmolality and plasma volume. Diabetes insipidus occurs when ADH (vasopressin) is not secreted (head trauma, pituitary tumor) or when the kidney does not respond to it (nephrogenic di). Ethanol inhibits adh, (vasopressin) as does atrial naturetic protein, but these are lesser influences than osmolality and volume. ...Read more
Modified amino acids: Vasopressin is a naturally occuring peptide hormone - a chain of Amino Acids linked together. Desmopressin is a synthetic peptide with substitution of two different Amino Acids (cystine at the 1 position is changed to a deaminated form; and the arginine at the 8 position is the d form instead of the l form used in all naturally occuring peptides and proteins). ...Read more
Snake oil: It is one of many unregulated, un tested, and non-sensical agents sold for the purpose of weight loss. Its claim is adrenal regulation, but there are no ingredients in it to do that; if there were, it would be only used for specific syndromes managed under the care of an endocrinologist. Ask your doctor about a diet and exercise program. ...Read moreSee 1 more doctor answer
Difference in vessel: This is a protective mechanism. The vessels in the brain dont have as much ability to contract compared to peripheral blood vessels. The brain is the main server of the body and has to be protected to keep the rest of the body functioning. The peripheral vessels constricting causes shunting of the blood towards the path of least resistance. ...Read more
Nocturia: Hi. How many times do you get up to pee on an average night? Diabetes insipidus (poor ADH (vasopressin) production or function) is a very uncommon cause of nocturia. The most common is drinking a lot in the evening. Diabetes mellitus is also a common cause of nocturia. Congestive heart failure or any cause of lower extremity edema where the kidneys still work will cause nocturia. ...Read more
Edema of whole body - weight increase of 5-6lbs, following endurance events (4-7 hours of exercise) - resolves spontaneously vasopressin related?
Body heal thy self: Endurance is a depletion event. The body has injury and attempts to regain balance. It can overcorrect and then return to homeostasis. ...Read more
In what circumstances will aldosterone be secreted over ADH (vasopressin) and vice versa. Are they both secreted in response to low BP? What about low plasma osm?
Good questions!: Aldosterone release is regulated by renin. I believe hypotension (or rather long-standing hypoperfusion) may be a trigger, especially in secondary aldosteronism (due to CHF, for example) ADH (vasopressin), (vasopressin) on the other hand, is triggered by hyperosmolarity, rather than hypotension. Low osmolarity will, of course, suppress ADH (vasopressin). ...Read more
Causes contractions: Vasopressin causes constriction and contraction of the small blood vessels(arterioles). Oxytocin cause contractions of the smooth muscle of the uterus. Both of these entities are made in a place some distance form their target organs but are very effective in the job they do. ...Read moreSee 1 more doctor answer