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Doctor insights on: Piperacillin And Tazobactam

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Dr. Eric Weisman
12 doctors shared insights

Piperacillin And Tazobactam (Overview)

Piperacillin|tazobactam is a fourth generation cephalosporin which is a kind of cephalosporin type drug (anti-bacterial drug, antibiotic and antimicrobial).


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Piperacillin/tazobactam IV will kill klebsiella pneumonia bacteria?

Piperacillin/tazobactam IV will kill klebsiella pneumonia bacteria?

It may but...: It depends on the resistance profile of specific strain of klebsiella. Many strains acquired in the 'community' are very sensitive to almost all antimicrobials except penicillin and Ampicillin and certainly sensitive to piperacillin/tazobactam. However, especially when acquired in a hospital, klebsiella can be quite resistant to therapy including pip/tazobactam. ...Read more

Dr. Eric Weisman
12 doctors shared insights

Piperacillin And Tazobactam (Overview)

Piperacillin|tazobactam is a fourth generation cephalosporin which is a kind of cephalosporin type drug (anti-bacterial drug, antibiotic and antimicrobial).


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Piperacillin/tazobactam IV will kill klebsiella pneumonia bacteria?

It may but...: It depends on the resistance profile of specific strain of klebsiella. Many strains acquired in the 'community' are very sensitive to almost all antimicrobials except penicillin and Ampicillin and certainly sensitive to piperacillin/tazobactam. However, especially when acquired in a hospital, klebsiella can be quite resistant to therapy including pip/tazobactam. ...Read more

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What does the body do with the piperacillin?

Excrete it: Piperacillin is excreted from the body in the urine by the kidneys and in the bile by the liver. With normal kidney function 1/2 of the drug is excreted every hour. ...Read more

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How long does it take for piperacillin/tazobac , 3.375g IV drip to become effective?

How long does it take for piperacillin/tazobac , 3.375g IV drip to become effective?

Depends on what is..: Meant for effective and what is being treated and where the infection is. Usually with 12-24 hours, objective criteria of improvement such as decreasing temperature, decreasing white blood cell count and improvement in symptoms. ...Read more

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If you are allergic to penicillin will you be allergic to piperacillin?

If you are allergic to penicillin will you be allergic to piperacillin?

We assume yes: We assume yes but since many people's allergies are not correct - eg they had coincidental rash while on penicillin, etc it may or may not be true. Since we almost never need to use penicillin so if you tell us you are allergic we usually will not chance a reaction. ...Read more

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Do they give a patient zosyn when allergc to penicilln?

Generally no: But it depends on the allergy and the indication. If the allergy to penicillin is mild and the indication is for a life threatening illness, then zosyn (piperacillin/tazobactam) can be cautiously used. ...Read more

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Why give a patient zosyn if allergc to penicilln?

Why give a patient zosyn if allergc to penicilln?

You shouldn't: You shouldn't. Zosyn contains the penicillin class antibiotic piperacillin which would have a very high likelihood for cross allergenicity with other drugs of the penicillin class. ...Read more

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How does alcohol affect zosyn?

How does alcohol affect  zosyn?

No: No problem taking penicillin class antibiotics with alcohol but keep it to a minimum if at all. If you have a significant infection it would be best to abstain until the infection has resolved. ...Read more

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Dr. Caroline Vitale
63 doctors shared insights

Piperacillin (Definition)

Piperacillin sodium is a fourth generation cephalosporin which is a kind of cephalosporin type drug (anti-bacterial ...Read more


Dr. Michael Kleerekoper
12 doctors shared insights

Zosyn (Definition)

Zosyn is a fourth generation cephalosporin which is a kind of cephalosporin type drug (anti-bacterial ...Read more