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Doctor insights on: Piperacillin And Tazobactam

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Dr. Ira Katz
13 doctors shared insights

Piperacillin And Tazobactam (Overview)

Piperacillin|tazobactam is a fourth generation cephalosporin which is a kind of cephalosporin type drug (anti-bacterial drug, antibiotic and antimicrobial).


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Piperacillin/tazobactam IV will kill klebsiella pneumonia bacteria?

Piperacillin/tazobactam IV will kill klebsiella pneumonia bacteria?

It may but...: It depends on the resistance profile of specific strain of klebsiella. Many strains acquired in the 'community' are very sensitive to almost all antimicrobials except penicillin and Ampicillin and certainly sensitive to piperacillin/tazobactam. However, especially when acquired in a hospital, klebsiella can be quite resistant to therapy including pip/tazobactam. ...Read more

Dr. Ira Katz
13 doctors shared insights

Piperacillin And Tazobactam (Overview)

Piperacillin|tazobactam is a fourth generation cephalosporin which is a kind of cephalosporin type drug (anti-bacterial drug, antibiotic and antimicrobial).


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How does alcohol affect zosyn (piperacillin and tazobactam)?

How does alcohol affect  zosyn (piperacillin and tazobactam)?

No: No problem taking penicillin class antibiotics with alcohol but keep it to a minimum if at all. If you have a significant infection it would be best to abstain until the infection has resolved. ...Read more

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Why give a patient zosyn (piperacillin and tazobactam) if allergc to penicilln?

Why give a patient zosyn (piperacillin and tazobactam) if allergc to penicilln?

You shouldn't: You shouldn't. Zosyn (piperacillin and tazobactam) contains the penicillin class antibiotic piperacillin which would have a very high likelihood for cross allergenicity with other drugs of the penicillin class. ...Read more

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Do they give a patient zosyn (piperacillin and tazobactam) when allergc to penicilln?

Do they give a patient zosyn (piperacillin and tazobactam) when allergc to penicilln?

Generally no: But it depends on the allergy and the indication. If the allergy to penicillin is mild and the indication is for a life threatening illness, then zosyn (piperacillin and tazobactam) (piperacillin/tazobactam) can be cautiously used. ...Read more

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For diabetic ulcer foot infections what's good? Zosyn (piperacillin and tazobactam)?

For diabetic ulcer foot infections what's good? Zosyn (piperacillin and tazobactam)?

Yes: Zosyn (piperacillin and tazobactam) is one of several antibiotics that is effective as empiric treatment for diabetic foot infections. Wound cultures guide definitive antibiotic treatment. You need to keep your diabetes under tight control to prevent development of peripheral vascular disease and neuropathy which predispose to serious diabetic foot infections and osteomyelitis. ...Read more

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Peritonitis, tried zosyn (piperacillin and tazobactam) and now meropenem, white blood count still high and no change in numbers. How long till it starts working?

Peritonitis, tried zosyn (piperacillin and tazobactam) and now meropenem, white blood count still high and no change in numbers. How long till it starts working?

See below: Your antibiotic treatment for bacterial peritonitis has been appropriate. You should have a repeat ct scan of the abdomen and pelvis to look for an undrained abscess that can be drained and cultured. Knowing the cause of the peritonitis and the diagnostic studies to date would be important in determining treatment recommendations. Hope you get better soon. ...Read more

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Piperacillin/tazobactam IV will kill klebsiella pneumonia bacteria?

It may but...: It depends on the resistance profile of specific strain of klebsiella. Many strains acquired in the 'community' are very sensitive to almost all antimicrobials except penicillin and Ampicillin and certainly sensitive to piperacillin/tazobactam. However, especially when acquired in a hospital, klebsiella can be quite resistant to therapy including pip/tazobactam. ...Read more

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What does the body do with the piperacillin?

What does the body do with the piperacillin?

Excrete it: Piperacillin is excreted from the body in the urine by the kidneys and in the bile by the liver. With normal kidney function 1/2 of the drug is excreted every hour. ...Read more

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How long does it take for piperacillin/tazobac , 3.375g IV drip to become effective?

How long does it take for piperacillin/tazobac , 3.375g IV drip to become effective?

Depends on what is..: Meant for effective and what is being treated and where the infection is. Usually with 12-24 hours, objective criteria of improvement such as decreasing temperature, decreasing white blood cell count and improvement in symptoms. ...Read more

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If you are allergic to penicillin will you be allergic to piperacillin?

If you are allergic to penicillin will you be allergic to piperacillin?

We assume yes: We assume yes but since many people's allergies are not correct - eg they had coincidental rash while on penicillin, etc it may or may not be true. Since we almost never need to use penicillin so if you tell us you are allergic we usually will not chance a reaction. ...Read more

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I live in a nursing home they diagnosed me pneumonia they are giving 6000 ml of vancomysin a day 750 ml of levaquin, (levofloxacin) and 100 ml of zosyn a day its ok?

I live in a nursing home they diagnosed me pneumonia they are giving 6000 ml of vancomysin a day 750 ml of levaquin, (levofloxacin) and 100 ml of zosyn a day its ok?

Doses not right: In specific circumstances Levaquin (levofloxacin) is added to Zosyn and Vancomycin, which would be a typical combination for a healthcare associated pneumonia. The dose listed for Levaquin (levofloxacin) seems to be right, providing no kidney issues. The doses for Vancomycin and Zosyn do not seem to be right. ...Read more

Dr. Caroline Vitale
63 doctors shared insights

Piperacillin (Definition)

Piperacillin sodium is a fourth generation cephalosporin which is a kind of cephalosporin type drug (anti-bacterial ...Read more


Dr. Amrita Dosanjh
13 doctors shared insights

Zosyn (Definition)

Zosyn is a fourth generation cephalosporin which is a kind of cephalosporin type drug (anti-bacterial ...Read more