Doctor insights on:
Phlebotomy For Secondary Polycythemia
Is there a possible link between hereditary hemochromatosis, polycythemia vera (primary jak2 mutation), & idiopathic pulmonary arterial hypertension?
How is polycythemia rubra vera differentiated from polycythemia associated with stress? RBC only elevated once in life. HGB/HCT elevated often.
Stress?: Stress doesn't cause polycythemia. Being dehydrated is a common cause. If your Hgb/Hct is only slightly elevated, stop worrying -- reference ranges are set so that several percent of healthy folks fall outside. If it's well above, consider a workup for the causes, including a variant hemoglobin and a subtle right-to-left shunt. ...Read more
Polycythemia: P. vera is a primary proliferation of certain bone marrow cells resulting in elevations of the platelet count in the blood. It is considered a pre-neoplastic disorder and merits watching, a bone marrow biopsy perhaps and possible cytogenetic tests. Secondary thrombocythemia is a "reactive" elevation of the platelet count, such as due to anemia, with no malignant potential. ...Read more
NO: The average lifespan for someone with polycythemia is about the same as it is without polycythemia. The risk of complications of the disease can be decreased with treatment, when appropriate. This may include Aspirin to decrease the risk of blood clots, phlebotomy to decrease the red blood cell count, and/or medication to control the blood counts. ...Read more
Yes: PRV is hypercoaguable conditionGet a more detailed answer ›
Not that I know of.: The big changes of this are elevated rbc count, hemoglobin, hematocrit, and decreased ESR (erythrocyte sedimentation rate). The elevations come without decrease in volume, and can be up to 70-80% for hematocrit, and 8-9 million rbc count. Changes in RDW may be from so many rbc's in the system, but even if they do occur, do not apparently have effect on prognosis or relevance to the cause of this. ...Read more
Depends.: Prv patients are advised to take Aspirin for clot prevention. Anticoagulants like warfarin or xarelto have specific indications such as treatment for a blood clot or stroke prophylaxis in heart disease. I would not use it outside those indications because of greater bleeding risk vs aspirin. No published data on xarelto in prv but should be ok for proper indications. ...Read more
Underlying cause: It all depends on the underlying cause of your Secondary polycythemia. The most common cause of polycythemia is low oxygen (hypoxia) secondary to lung (pulmonary) disease like emphysema, R to L shunts in heart or some arterio venous malformation in your lung is resent. All these can cause low blood Oxygen level and thus your kidney responds by increasing Erythropoietin which stimulates your bone ...Read more
Can patient with Polycythemia vera have normal hemoglobin and hematocrit count but abnormal JAK2 result ? what is definitive test for PV ?
See below: There is more than one factor that needs to be taken into consideration. High hemoglobin, low erthyropoietin and JACK 2 all need to be looked at. You may consult this site for more information on this topic. http://www.mayoclinic.org/diseases-conditions/polycythemia-vera/basics/definition/con-20031013 ...Read more
10% of patients: Itp is a disorder where the body forms antibodies that attach to your platelets leading to their early destruction. The greatest risk of itp is bleeding, which can occur with platelet counts below 20-30, 000. Most people will respond to medical management; if unresponsive, splenectomy is an option, with more than 2/3 of all surgical patients responsive to this treatment. ...Read moreSee 1 more doctor answer
Can iron deficiency anemia consider normal response to post- nephrectomy for clear cell renal cancer without metastasis?
No.: I would be looking for another cause if you have iron deficiency anemia. If you have one functioning kidney, you are probably making enough erythropoietin (which is important in regulating red cell production) but a low epo level would give you a different kind of anemia. Usually iron deficiency anemia in a 60 year old male is due to some sort of blood loss, assuming a normal diet. ...Read moreSee 1 more doctor answer
Yes, very: Hi. Yes, in fact, that's a big part of the diagnosis. ...Read more
Yes: I am not an expert, but it is my understanding that for many, it is the treatment of choice. I think most patients just go and essentially give blood about once a week and everything works out very well. A hematologist is the type of specialist that one with this condition should see for evaluation and treatment. ...Read moreSee 2 more doctor answers
What does this mean? "Severe crythroid hyperplasia consistent with hematological diagnosis of polycythemia vera"
Erythroid hyperplasi: Erythroid hyperplasia is an excess of red blood cell precursors in the bone marrow. This is can be due to benign/reactive or neoplastic processes. Polycythemia vera is a primary bone marrow disease in which too many red cells (erythroid cells) are produced due to mutation in a cell line. diagnosis is made on blood findings. This is chronic disease (not same as acute leukemia) but needs treatment ...Read more
stop platelet destr: Idiopathic thrombocytic purpura is a disease whereby your immune system develops antibodies against itself, specifically your platelets which are important for preventing or stopping bleeding. Your spleen is the organ responible for collecting and destroying your platelets.Therefore those patients whose disease is not responive to medications may require spenectomy to decrease their destrucion. ...Read moreSee 1 more doctor answer
52yr f, suspected acute leukemia, white blood cell count 25.0, bruising, fatigue, to receive blood transfusions.How serious is this?Is this fatal in adults
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