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Doctor insights on: Pheo Chromocytoma

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Is it common to see high plasma free normetanephrine of 1.2 nmol (pf met < .20, w/ previous elevated total normet)? Do you rule out pheo if a later urine normet is normal w/ pf normet of 0.65 nmol?

Is it common to see high plasma free normetanephrine of 1.2 nmol (pf met < .20, w/ previous elevated total normet)?  Do you rule out pheo if a later urine normet is normal w/ pf normet of 0.65 nmol?

Pheo and labs : In pheochomocytoma, typically the values range 3x the upper limit of normal. The episodes can be intermittent, so you cannot be totally reassured by normal values if you are clinically suspicious. A Clonidine suppression test may be helpful. ...Read more

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24 hour urine catecholamine for a pheo- if a person does not have an episode during the 24 hours would it still show elevated levels. If so how?

24 hour urine catecholamine for a pheo-  if a person does not have an episode during the 24 hours would it still show elevated levels. If so how?

Usually, yes: A pheo usually secretes catecholamines continuously, so it is not usually necessary to time the collection. These catecholamines yield a lot of breakdown products (eg. metanephrines). However, in some circumstances, if there is a very high suspicion for pheo and the initial tests are negative, and the attacks are sporadic, a urine collection timed with the episode is reasonable. ...Read more

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Had a pheo removed 2011. Hypertension again. Does removing one adrenal gland change reliabilty of met urine test?

Had a pheo removed 2011. Hypertension again. Does removing one adrenal gland change reliabilty of met urine test?

Terrific question!: This may be one of the best questions i've ever seen on healthtap! unfortunately, i don't have a clue. I hope an endocrinologist with some experience with this answers - we'll both learn something. Pheo's are statistically literally one in a million. Still, if you had one, you might be at higher risk for two. ...Read more

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Have high epinephrine, tachy, dizzy, headache... daily. Dr sending for u/s to rule out pheo. U/S waste of time or should I ask for MRI? Had U/S 2014

Have high epinephrine, tachy, dizzy, headache... daily. Dr sending for u/s to rule out pheo. U/S waste of time or should I ask for MRI? Had U/S 2014

Pheochromocytoma: The diagnosis of pheochromocytoma needs to be made biochemically before doing any studies to look for a tumor. Plasma and urine catecholamines, metanephrines, and/or VMA are typically significantly abnormal. A chromogranin A level can also be helpful. Once the diagnosis is made, localization studies including MRI and/or MIBG scans is indicated. Doing a scan before a diagnosis can be misleading ...Read more

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High hr (up to 180bpm), sob, tingly hands, flushed, rush feeling, high urine adrenalune. Doc says pheo too rare and no imaging? Feel terrible. Advice?

High hr (up to 180bpm), sob, tingly hands, flushed, rush feeling, high urine adrenalune. Doc says pheo too rare and no imaging? Feel terrible. Advice?

Seek other advice: While pheo's are incredibly rare, your symptoms are obviously coming from some issue. It's not normal to have HR's in the 180's unless you are really exercising hard at the time. Is it possible to get a second opinion to better sort through things? How high was your urine epinephrine(adrenaline)? ...Read more