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Doctor insights on: Pet Lymphoma Restaging

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Is a full body pet scan good in the diagnosis of lymphoma?

Is a full body pet scan good in the diagnosis of lymphoma?

Very good test: Pet/ct is used quite often in the initial diagnosis and restaging of many types of lymphoma. Lymphoma consumes glucose at a much higher rate than normal tissues.

That makes pet/ct with f-18 fdg, which images glucose metabolism, is a great test for lymphoma. ...Read more

Dr. Michael Thompson
1,759 Doctors shared insights

Lymphoma (Definition)

A malignancy developing in the lymphocytes of lymph glands. They present as an enlarging node that continues to grow and then ...Read more


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Can hodgkin lymphoma transform to NHL? After 4 cycle of ABVD, PET showed an area with SUV 14. Initial diagnosis was HL IIb, bulky.

Can hodgkin lymphoma transform to NHL? After 4 cycle of ABVD, PET showed an area with SUV 14. Initial diagnosis was HL IIb, bulky.

Yes it can: This change has been reported, so it is entirely possible. But only a biopsy of the new area or the growing lymph node can determine what is going on. Your oncologist should be able to help address this matter for you. Or you can seek a second opinion from another medical oncologist, if you are not totally satisfied with your current oncologist. ...Read more

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How does pet scans work when detecting possible lymphoma? Does "hot spots" mean malignancy?

How does pet scans work when detecting possible lymphoma? Does "hot spots" mean malignancy?

No: A hot spot means an area of increased sugar utilization. Can be inflammatory, infectious or malignant. ...Read more

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What is the definition or description of: pet-ct lymphoma diagnosis?

What is the definition or description of: pet-ct lymphoma diagnosis?

PET/CT staging: Lymphoma is diagnosed by the microscopic appearance of a tumor biopsy. It is further classified by studies of the expression of molecules on the surface of tumor cells (e.g. with antibody staining) and by tumor gene mutation studies. PET/CT on the other hand, is used to determine the "stage" of the disease, meaning its location and how widespread it is. Both are important for optimal treatment. ...Read more

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Hodgkin lymphoma, stage IIb, bulky. 130mm, after 8 cycle of ABVD, PET +, hypermetabolic mass and increase its size to 141mm! Why? Is Stanford V helpful?

Hodgkin lymphoma, stage IIb, bulky. 130mm, after 8 cycle of ABVD, PET +, hypermetabolic mass and increase its size to 141mm! Why? Is Stanford V helpful?

Jury not out: There is ongoing trial to answer your question but previous studies suggest ABVD superior. That said, factors such as radiotx and personal immune response to Hodgkin D need to be considered. Fail cases to conventional chemoradiotx appear to respond to immune therapy, ie. PD-1 Blockade with Nivolumab in Relapsed or Refractory Hodgkin's Lymphoma N Engl J Med 2015; 372:311-319. Confirm ur dx 1st step ...Read more

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1.5 to 1.9cm, 2 lymph nodes neat suspected thymoma in ant mediastinum. Pet suv was 3.8 for thymoma and 4.7 for 1.9 node. Could it it by lymphoma?

Maybe: There are typical appearances of certain cancers but none are specific enough to provide a diagnosis. What you describe sounds worrisome for a malignant thymoma or thymic carcinoma with metastases to lymph nodes. Could it be lymphoma? Yes. Could it be lung cancer metastatic to nodes and thymoma? Yes. A biopsy is needed to make the correct diagnosis. Case presentation at a tumor board is best. ...Read more

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14 yr old sister had lymphoma 2 yrs ago and now they see something in pet scan in esophagus. What could it be? Please any ideas

14 yr old sister had lymphoma 2 yrs ago and now they see something in pet scan in esophagus. What could it be? Please any ideas

See below: You can get physiologic uptake in the esophagus which is normal. It is atypical for lymphoma to recur only in the esophagus. It could periodically be in a lymph node adjacent to the esophagus. I would recommend at least getting an upper endoscopy. ...Read more

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Is Full body PET scan or CT scan better for diagnosing Lymphoma? Which uses less radiation?

Is Full body PET scan or CT scan better for diagnosing Lymphoma? Which uses less radiation?

Both: The actual diagnosis of lymphoma requires tissue, usually excisional biopsy of an entire lymph node. Staging to see where other sites of disease could be is done with a combined PET/CT. The staging used to matter more many years ago when they would often give XRT or do surgery, it doesn't matter as much as it used to because almost everybody gets systemic chemotherapy for both Hodkins and non H ...Read more

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2 enlarged lymph nodes in the ant mediastinum, pet suv of abt 4.7, suspected thymoma nearby. Can this be lymphoma?

2 enlarged lymph nodes in the ant mediastinum, pet suv of abt 4.7, suspected thymoma nearby. Can this be lymphoma?

Depends on the size: You need to tell us what the ct scan shows in the mediastinum? Are the lymph nodes enlarged? What is their size? You need a follow up ct/pet scan in a couple of months, unless your lymph nodes are larger than 2cm size. Tell us more details. ...Read more

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My pet-ct scan for hotpshkins lymphoma came up with increased metabolic activity around brown fat in base of neck, should I be concerned?

My pet-ct scan for hotpshkins lymphoma came up with increased metabolic activity around brown fat in base of neck, should I be concerned?

No: Brown fat is metabolically active in order generates heat, and for this reason more likely to be active during the winter months. Since brown fat uses more glucose than normal fat, it lights up on a FDG pet. Correlation of pet images with the ct portion of the exam can easily identify the active regions as fat rather than lymph nodes or tumor. Typical location is around the clavicles. ...Read more

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Pet scan=many swollen lymph nodes-ongoing 9mo-would lymphoma definitely show on a pet? Can it be diagnosis from just pet? Biopsy 3wks away & feeling impatient

Pet scan=many swollen lymph nodes-ongoing 9mo-would lymphoma definitely show on a pet? Can it be diagnosis from just pet? Biopsy 3wks away & feeling impatient

Biopsy is the Answer: Pet scan only tells us that something is wrong (metabolically active). It can not tell the difference between infection and cancer. So biopsy is essential to find out what is going on inside the lymph nodes. Lymphoma is only likely if the nodes are quite large in size and have steadily increased in size over 9 months that you have been pursuing them. What the size range of your lymph nodes? ...Read more

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Can Splenic Marginal zone lymphoma be missed in PET/CT and flow cytometry in early stages?

Yes: If there is not impressive splenomegaly / enlarge lymph nodes and there are no / few lymphoma cells in the blood, it will be impossible to make the call, and probably not even possible to suspect the illness. ...Read more

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How often does a "retroperitoneal attenuation" (found on CT urogram) turn out to be lymphoma? My dad is being tested for this. PET scan next. Worried.

Not often: Retro peritoneal attenuation is and unusual term on ct. CT is usually very good at detecting enlarged lymph nodes of lymphoma. And understand that not all lymphomas will be best seen with PET. Also not every positive PET CT is cancer. There are other disease entities that are positve on PET. Talk honestly with the doctor to wxplain the results ...Read more

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Can small bowel lymphoma (lymphoma of mesentery) being missed on whole-body PET/CT scan?

Can small bowel lymphoma (lymphoma of mesentery) being missed on whole-body PET/CT scan?

Yes: PET/CT is usually very good for finding small bowel lymphoma. That said, technique, small size, histology, etc could contribute to a miss. ...Read more

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My grandpa just got dx with mantle cell lymphoma by biopsy 82y/o. bone marrow biopsy & pet scan not back. Prognosis & treatment? Is it genetic?

My grandpa just got dx with mantle cell lymphoma by biopsy 82y/o. bone marrow biopsy & pet scan not back. Prognosis & treatment? Is it genetic?

Not genetic: MCL is a serious type of lymphoma. So he should be checked and treated by a Lymphoma specialist. With good treatment we can extend life for 3- 5 years. ...Read more

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35yr female, mri showed tumor on t6, pet scan showed hypermetabolism in lymph nodes neck, chest, med. Focal uptake in esophagus. What can that be? Lymphoma

35yr female, mri showed tumor on t6, pet scan showed hypermetabolism in lymph nodes neck, chest, med. Focal uptake in esophagus. What can that be? Lymphoma

Lymphoma: A biopsy of the lymph node or one of the other sites is required to establish a diagnosis. The T6 lesion can be biopsied and bone cement placed in the vertebral body (kyphoplasty/vertebroplasty) if the pain is significant between the shoulder blades. An oncologist can provide a plan for treatment. ...Read more

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I have a 3cm ant medistinum mass, weight loss and a cough. Can it be lymphoma or can doctors tell if it's thymoma? Pet and CT scan were inconclusive.

I have a 3cm ant medistinum mass, weight loss and a cough. Can it be lymphoma or can doctors tell if it's thymoma? Pet and CT scan were inconclusive.

Needs biopsy: A pet scan negative (no hypermetabolic lesions) is good news but some of the cancers are not pet avid and therefore a biopsy is warranted to rule out malignancy. ...Read more

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Could splenic lymphoma exist even with Negative Bone marrow biopsy & negative PET/CT, but splenomegaly occur? Other causes has ruled out.

Could splenic lymphoma exist even with Negative Bone marrow biopsy & negative PET/CT, but splenomegaly occur? Other causes has ruled out.

Yes/No: Lymphoma can, on rare occasions, involve spleen alone, sparing all other organs. But PET will show increased uptake (high SUV) and CT would show enlargement of Spleen.
So depending on your symptoms and the degree of enlargment of your spleen, your doctor may, somewhere along the line, consider removal of the spleen (splenectomy). But this step would only be taken if your spleen is causing U any harm ...Read more

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Thoracic surgeon and radiologist is leaning towards thymoma from pet and CT scans. 2 enlarged nodes near thymus tumor. Can they tell if lymphoma?

Thoracic surgeon and radiologist is leaning towards thymoma from pet and CT scans. 2 enlarged nodes near thymus tumor. Can they tell if lymphoma?

Nonspecific pet/ct.: Pet/ct scans are very sensitive for identifying disease, but not as specific as to what type of disease. On some occasions, the appearance and distribution of disease on these scans can specifically identify one disease. More often tissues/nodes would need to be biopsied to be studied under a microscope by a pathologist to specify actual disease type/subtype and can aide in treatment options. ...Read more

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Hello doctor....my lymph node swollen and I got fever and tiredness for 10 days, and PET CT scan says it seems to be like lymphoma but biopsy result s?

Hello doctor....my lymph node swollen and I got fever and tiredness for 10 days, and PET CT scan says it seems to be like lymphoma but biopsy result s?

Lymphoma diagnosis: Signs and symptoms plus or minus a Pet or CT scan can suggest a diagnosis of lymphoma but a diagnosis needs to be confirmed by an excision biopsy of an entire node. A lot of other diagnoses can mimic lymphoma on scans. History and physical can narrow the choices. ...Read more

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Do many have lymphoma?

Do many have lymphoma?

Estimate: About 80, 000 cases are expected in the us in the next year based on the seer database. ...Read more

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Do you know what causes lymphoma?

Like other cancers..: lymphoma arises from an unlucky combination of genetic mutations in lymphoid cells during our lifetime. Risk factors include exposure to toxins, family history, or a severe immune suppression (e.g. HIV). Most often, the proximal cause can not be determined, and is mostly just bad luck, since our body is naturally subjected to millions of genetic mutations over our lifetime. ...Read more

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Are there easy tests for lymphoma?

See below...: Usually a lymph node biopsy is necessary to establish the diagnosis unquestionably. ...Read more

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How can I tell if I have lymphoma?

Normal nodes can be: Found from head to toe, and lymphoma can arise in any place where nodes are, and even "extranodal" sites. Fever, weight loss, and drenching sweats are called b symptoms, indicating a wore prognosis, pruritus or itching is another finding. There is the hodgkin's type, and a variety of others. This is very treatable and curable. ...Read more

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How likely is dying from lymphoma?

Depends what type: There are about 60 types of lymphomas, some very indolent with survival same as normal people, and many with moderate prognosis, with survival measured in 5 to 10 years. Rare few are quite aggressive with survival measured in months or weeks. Best know exactly what kind and the diagnosis by expert will predict probability of survival. Talk to your doc. Lymphoma is a misnomer, it is not one disease ...Read more

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How do I know if I have lymphoma?

It depends on urheal: Your health and symptoms can be indicators of the nature of an ilness. You may not be able to predict it but if you are unwell, your doctor would investigate the cause. The symptoms suggestive of lymphoma will include general ill health associated with fevers and enlarged lymph nodes in any of your body areas. Ultimately a biopsy of a mass or an enlarged node will be required to confirm this diag. ...Read more

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What are some symptoms of lymphoma?

Many: Symptoms can include one or many of the following and others: enlarged lymph nodes (swollen glands), fevers, chills, night sweats, weight loss, itching, new rash, pain, or even unusual things like chest pain after drinking alcohol. ...Read more

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What are the usual lymphoma symptoms?

Variety: It can include fatigue, fevers, night sweats, swollen lymph nodes, bone pain, recurrent infections, anemia. ...Read more