Doctor insights on:
Pet Lymphoma Restaging
Can hodgkin lymphoma transform to NHL? After 4 cycle of ABVD, PET showed an area with SUV 14. Initial diagnosis was HL IIb, bulky.
Yes it can: This change has been reported, so it is entirely possible. But only a biopsy of the new area or the growing lymph node can determine what is going on. Your oncologist should be able to help address this matter for you. Or you can seek a second opinion from another medical oncologist, if you are not totally satisfied with your current oncologist. ...Read more
PET/CT staging: Lymphoma is diagnosed by the microscopic appearance of a tumor biopsy. It is further classified by studies of the expression of molecules on the surface of tumor cells (e.g. with antibody staining) and by tumor gene mutation studies. PET/CT on the other hand, is used to determine the "stage" of the disease, meaning its location and how widespread it is. Both are important for optimal treatment. ...Read more
Hodgkin lymphoma, stage IIb, bulky. 130mm, after 8 cycle of ABVD, PET +, hypermetabolic mass and increase its size to 141mm! Why? Is Stanford V helpful?
Jury not out: There is ongoing trial to answer your question but previous studies suggest ABVD superior. That said, factors such as radiotx and personal immune response to Hodgkin D need to be considered. Fail cases to conventional chemoradiotx appear to respond to immune therapy, ie. PD-1 Blockade with Nivolumab in Relapsed or Refractory Hodgkin's Lymphoma N Engl J Med 2015; 372:311-319. Confirm ur dx 1st step ...Read more
1.5 to 1.9cm, 2 lymph nodes neat suspected thymoma in ant mediastinum. Pet suv was 3.8 for thymoma and 4.7 for 1.9 node. Could it it by lymphoma?
Maybe: There are typical appearances of certain cancers but none are specific enough to provide a diagnosis. What you describe sounds worrisome for a malignant thymoma or thymic carcinoma with metastases to lymph nodes. Could it be lymphoma? Yes. Could it be lung cancer metastatic to nodes and thymoma? Yes. A biopsy is needed to make the correct diagnosis. Case presentation at a tumor board is best. ...Read more
14 yr old sister had lymphoma 2 yrs ago and now they see something in pet scan in esophagus. What could it be? Please any ideas
Results of PET Scan "initial staging of lymphoma" and "extensive adenophy in the neck, chest and abdomen" how serious is this?
Abnormal PET scan: It would help if we have the results of a node or marrow biopsy. Not all adenopathy is malignant. ...Read more
Both: The actual diagnosis of lymphoma requires tissue, usually excisional biopsy of an entire lymph node. Staging to see where other sites of disease could be is done with a combined PET/CT. The staging used to matter more many years ago when they would often give XRT or do surgery, it doesn't matter as much as it used to because almost everybody gets systemic chemotherapy for both Hodkins and non H ...Read more
2 enlarged lymph nodes in the ant mediastinum, pet suv of abt 4.7, suspected thymoma nearby. Can this be lymphoma?
My pet-ct scan for hotpshkins lymphoma came up with increased metabolic activity around brown fat in base of neck, should I be concerned?
No: Brown fat is metabolically active in order generates heat, and for this reason more likely to be active during the winter months. Since brown fat uses more glucose than normal fat, it lights up on a FDG pet. Correlation of pet images with the ct portion of the exam can easily identify the active regions as fat rather than lymph nodes or tumor. Typical location is around the clavicles. ...Read more
Pet scan=many swollen lymph nodes-ongoing 9mo-would lymphoma definitely show on a pet? Can it be diagnosis from just pet? Biopsy 3wks away & feeling impatient
Biopsy is the Answer: Pet scan only tells us that something is wrong (metabolically active). It can not tell the difference between infection and cancer. So biopsy is essential to find out what is going on inside the lymph nodes. Lymphoma is only likely if the nodes are quite large in size and have steadily increased in size over 9 months that you have been pursuing them. What the size range of your lymph nodes? ...Read more
Any treatment for eye lymphoma after some of part was remove from eyelid, pet scan was done and nothing else on the body was found.
Yes: You need to see an oncologist to determine what is the next step for treatment. ...Read more
How often does a "retroperitoneal attenuation" (found on CT urogram) turn out to be lymphoma? My dad is being tested for this. PET scan next. Worried.
Not often: Retro peritoneal attenuation is and unusual term on ct. CT is usually very good at detecting enlarged lymph nodes of lymphoma. And understand that not all lymphomas will be best seen with PET. Also not every positive PET CT is cancer. There are other disease entities that are positve on PET. Talk honestly with the doctor to wxplain the results ...Read more
Yes: PET/CT is usually very good for finding small bowel lymphoma. That said, technique, small size, histology, etc could contribute to a miss. ...Read more
My grandpa just got dx with mantle cell lymphoma by biopsy 82y/o. bone marrow biopsy & pet scan not back. Prognosis & treatment? Is it genetic?
35yr female, mri showed tumor on t6, pet scan showed hypermetabolism in lymph nodes neck, chest, med. Focal uptake in esophagus. What can that be? Lymphoma
Lymphoma: A biopsy of the lymph node or one of the other sites is required to establish a diagnosis. The T6 lesion can be biopsied and bone cement placed in the vertebral body (kyphoplasty/vertebroplasty) if the pain is significant between the shoulder blades. An oncologist can provide a plan for treatment. ...Read more
I have a 3cm ant medistinum mass, weight loss and a cough. Can it be lymphoma or can doctors tell if it's thymoma? Pet and CT scan were inconclusive.
Could splenic lymphoma exist even with Negative Bone marrow biopsy & negative PET/CT, but splenomegaly occur? Other causes has ruled out.
Lymphoma can, on rare occasions, involve spleen alone, sparing all other organs. But PET will show increased uptake (high SUV) and CT would show enlargement of Spleen.
So depending on your symptoms and the degree of enlargment of your spleen, your doctor may, somewhere along the line, consider removal of the spleen (splenectomy). But this step would only be taken if your spleen is causing U any harm ...Read more
Thoracic surgeon and radiologist is leaning towards thymoma from pet and CT scans. 2 enlarged nodes near thymus tumor. Can they tell if lymphoma?
Nonspecific pet/ct.: Pet/ct scans are very sensitive for identifying disease, but not as specific as to what type of disease. On some occasions, the appearance and distribution of disease on these scans can specifically identify one disease. More often tissues/nodes would need to be biopsied to be studied under a microscope by a pathologist to specify actual disease type/subtype and can aide in treatment options. ...Read more
Hello doctor....my lymph node swollen and I got fever and tiredness for 10 days, and PET CT scan says it seems to be like lymphoma but biopsy result s?
Like other cancers..: lymphoma arises from an unlucky combination of genetic mutations in lymphoid cells during our lifetime. Risk factors include exposure to toxins, family history, or a severe immune suppression (e.g. HIV). Most often, the proximal cause can not be determined, and is mostly just bad luck, since our body is naturally subjected to millions of genetic mutations over our lifetime. ...Read more
Normal nodes can be: Found from head to toe, and lymphoma can arise in any place where nodes are, and even "extranodal" sites. Fever, weight loss, and drenching sweats are called b symptoms, indicating a wore prognosis, pruritus or itching is another finding. There is the hodgkin's type, and a variety of others. This is very treatable and curable. ...Read more
Depends what type: There are about 60 types of lymphomas, some very indolent with survival same as normal people, and many with moderate prognosis, with survival measured in 5 to 10 years. Rare few are quite aggressive with survival measured in months or weeks. Best know exactly what kind and the diagnosis by expert will predict probability of survival. Talk to your doc. Lymphoma is a misnomer, it is not one disease ...Read more
It depends on urheal: Your health and symptoms can be indicators of the nature of an ilness. You may not be able to predict it but if you are unwell, your doctor would investigate the cause. The symptoms suggestive of lymphoma will include general ill health associated with fevers and enlarged lymph nodes in any of your body areas. Ultimately a biopsy of a mass or an enlarged node will be required to confirm this diag. ...Read more