Doctor insights on:
Person Thalassemia Marry Safely
Yes: Marriage is no problem. Getting pregnant, however, may not be recommended if they have moderate or severe thalassemia. If they have only "trait", they will be fine if their children only inherit "no trait" or "trait from either mom or dad". If a child inherits "trait" from both mom and dad, the child might have a problem. A geneticist and hematologist can give more details for individual cases. ...Read moreSee 1 more doctor answer
Of course you can: A person can marry anyone they like. From a thalassemia perspective, and assuming your Alpha thal trait is in cis, your child has a 50/50 chance of being Alpha thal trait vs. Normal and a 50/50 chance of being beta thal trait vs. Normal. Given there is consideration of inheriting two distinct trait states, it would be prudent to sit with a genetic counselor to understand the implications clearly. ...Read more
It's possible. : Thalassemia is a condition characterized by reduced expression of either Alpha or beta globins, which together make up hemoglobin. There are people who have Alpha deficiencies that are clinically silent (so called silent carrier). Having a child with person with alpha-thal trait, for example, is one way to have a clinically significant alpha-thal. There are other possibilities as well. ...Read moreSee 1 more doctor answer
Safe if necessary: Blood transfusions are given only when necessary especially in the younger population or blood disorders. Transfusions are necessary for major bleeding resulting in shock, low blood pressures, or continued blood loss. All transfusions are screened and safe but there is always a 1-3% risk of a clerical error. Pts. With blood disorders face increased risk of blood transfusion reactions. ...Read moreSee 1 more doctor answer
Of course: It's always wise to stay well-hydrated if you have sickle-trait. ...Read more
4 alpha genes...: It is a bit complicated given that there are 4 Alpha chain genes and Alpha thalassemia can involve mutations in one, two (in two different ways) or three genes (mutations in four genes is usually not compatible with life). For excellent website, see: http://www.Stjude.Org/stjude/v/index.Jsp?Vgnextoid=d966885309c6f110vgnvcm1000001e0215acrcrd. ...Read moreSee 1 more doctor answer
Yes, but unlikely: A person with beta thalassemia trait may be not anemic or mildly anemic. If he is not anemic, he can be a blood donor. However, since he has a more difficult time making hemoglobin (to make new red blood cells), he may not wish to be a blood donor. ...Read moreSee 1 more doctor answer
Yes, but: Yes, but you should be tested to know your status if you plan to have children. The thalassemia minor won't hurt you at all. If your partner has thalassemia minor (i.e. Thalassemia trait), i would bet they are fine and have no issues. If you also have thalassemia trait, there is a chance you could have a baby with thalassemia (disease). You should see a genetic counselor. ...Read moreSee 1 more doctor answer
Thal trait: Maybe. Full disease no.Get a more detailed answer ›
Sickle cell trait: If you have the trait you can donate blood, but if you have the disease you are not eligible ...Read more
They don't: Trisomy 13 is a spontaneous new event that occurs when 2 #13 chromosomes in either the egg (sperm) join with the one from the opposing side. The other 22 chromosomes pass only one of each. The fetus ends up with 47 chromosomes, not the normal 46. It is not passed on the genes like eye color or other features. It is an accident of nature. ...Read moreSee 1 more doctor answer
Depends: Do you have feelings for her? You must have at least made some entry level gestures. Does she love you or does she just want your cash, or security, or someone to help share childcare issues? Would she still want you if she had to sign a pre-nuptial agreement? Is there a significant age difference? So many questions. There are counselors for this as well. ...Read more
25-50-25: Generally, the hemoglobinopathies are inherited in an autosomal recessive fashion, which means you must have an abnormal copy of the gene from each of your parents. If each parent has one abnormal copy of the same gene, then each child has a 25% chance of being normal, a 50% chance of having one copy of the abnormal gene (trait), and a 25% chance of having two abnormal copies (thalassemia.). ...Read more
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