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Doctor insights on: Pernicious Anemia

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Pernicious Anemia (Overview)

It is a decline in the amount of red cells in the circulation as a result of impaired production in the bone marrow resulting from a lack of vitamin b12. This is most commonly as a consequence of impaired absorption due to an autoimmune condition affecting the stomach lining. If untreated, it may also lead to brain and spinal cord problems. It is easily treatable with replacement therapy.


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How does pernicious anemia cause people to have achlorhydria?

How  does pernicious anemia cause people to have achlorhydria?

The other way around: Achlorhydria (lack of adequate gastric acid production and secretion) is one of the causes of pernicious anemia and not the other way around. Normal gastric acid is essential for adequate absorption of vitamin b-12. Vitamin b-12 deficiency in turn causes pernicious anemia. ...Read more

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Pernicious Anemia (Overview)

It is a decline in the amount of red cells in the circulation as a result of impaired production in the bone marrow resulting from a lack of vitamin b12. This is most commonly as a consequence of impaired absorption due to an autoimmune condition affecting the stomach lining. If untreated, it may also lead to brain and spinal cord problems. It is easily treatable with replacement therapy.


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What are the causes of symptoms in pernicious anemia?

What are the causes of symptoms in pernicious anemia?

Lack of vitamin B12: Pernicious anemia is due to a lack of vitamin b12. B12 is necessary for the normal function of the nervous system and the formation of red blood cells. ...Read more

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What is pernicious anemia?

What is pernicious anemia?

An autoimmune : Disorder where your body makes antibodies so you can not absorb vitamin B12 so it has to be given by a shot to bypass the stomach and go directly into the bloodstream ...Read more

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Is there a specific blood test to diagnose pernicious anemia? I have a family history. My doctor told me I have borderline B12 deficiency.

Is there a specific blood test to diagnose pernicious anemia?  I have a family history. My doctor told me I have borderline B12 deficiency.

Pernicious anemia: Yes your doctor can run a battery of tests including a cbc, peripheral blood smear, a serum b 12 level, and a reticulocyte count. These usually will help to diagnose the condition. Sometimes methylmalonic acid and homocysteine levels will be drawn to help with the diagnosis. ...Read more

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I have pernicious anemia I don't take my B12 shot as directed before my regular check up and my levels show up fine. What does it mean?

I have pernicious anemia I don't take my B12 shot as directed before my regular check up and my levels show up fine. What does it mean?

Diagnosis confirmed?: Some people with PA can absorb some B12 orally, just not efficiently. Furthermore, B12 can last a while in the body before being depleted. If B12 is administered as injection intermittently, that may be enough to keep levels normal. ...Read more

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How can I treat pernicious anemia?

How can I treat pernicious anemia?

Cobalamin therapy: Try a trial of vitamin B12 (cobalamin) first and have a physician to repeat lab to ensure adequate dose. Also it may need additional therapies for cobalamin deficiency due to underlying diseases involving intestine or pancreas. Please check for Folic Acid deficiency as well and this may be related to nutritional deficiency. If you are a vegetarian, please take vitamin B12 daily. ...Read more

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What is the best treatment for pernicious anemia?

What is the best treatment for pernicious anemia?

Vitamin B12: True pernicious anemia is due to a lack of absorption of vitamin b 12 from your gastrointestinal tract.The treatment would be vitamin B12 injections given by your doctor.Sometimes large doses of oral vitamin b12, 1 to 2 mg daily can also help replenish your levels of vitamin b12.Your doctor can help decide which approach is best for you. ...Read more

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Dr. Steven Ginsberg
1,236 doctors shared insights

Anemia (Definition)

Anemia refers to any condition where there is a decrease in the red blood cells in the body. There are numerous causes of anemia but they can basically be broken down into 3 categories: decreased production of red blood cells increased destruction of red ...Read more