Top
30
Doctor insights on: Pernicious Anemia

Share

Pernicious Anemia (Overview)

A decrease in red blood cells when the body can't absorb enough vitamin B-12.


1

1
How does pernicious anemia cause people to have achlorhydria?

How does pernicious anemia cause people to have achlorhydria?

The other way around: Achlorhydria (lack of adequate gastric acid production and secretion) is one of the causes of pernicious anemia and not the other way around. Normal gastric acid is essential for adequate absorption of vitamin b-12. Vitamin b-12 deficiency in turn causes pernicious anemia. ...Read more

Pernicious Anemia (Overview)

A decrease in red blood cells when the body can't absorb enough vitamin B-12.


2

2
What are the causes of symptoms in pernicious anemia?

What are the causes of symptoms in pernicious anemia?

Lack of vitamin B12: Pernicious anemia is due to a lack of vitamin b12. B12 is necessary for the normal function of the nervous system and the formation of red blood cells. ...Read more

4

4
What is pernicious anemia?

What is pernicious anemia?

Pernicious anemia: It's a condition which results in low vitamin B12 leading to anemia. The person affected with this condition needs the B12 supplement by injection route as oral absorption is impaired. ...Read more

5

5
Is there a specific blood test to diagnose pernicious anemia? I have a family history. My doctor told me I have borderline B12 deficiency.

Is there a specific blood test to diagnose pernicious anemia? I have a family history. My doctor told me I have borderline B12 deficiency.

Pernicious anemia: Yes your doctor can run a battery of tests including a cbc, peripheral blood smear, a serum b 12 level, and a reticulocyte count. These usually will help to diagnose the condition. Sometimes methylmalonic acid and homocysteine levels will be drawn to help with the diagnosis. ...Read more

8

8
I have pernicious anemia I don't take my B12 shot as directed before my regular check up and my levels show up fine. What does it mean?

I have pernicious anemia I don't take my B12 shot as directed before my regular check up and my levels show up fine. What does it mean?

Diagnosis confirmed?: Some people with PA can absorb some B12 orally, just not efficiently. Furthermore, B12 can last a while in the body before being depleted. If B12 is administered as injection intermittently, that may be enough to keep levels normal. ...Read more

9

9
How can I treat pernicious anemia?

How can I treat pernicious anemia?

Cobalamin therapy: Try a trial of vitamin B12 (cobalamin) first and have a physician to repeat lab to ensure adequate dose. Also it may need additional therapies for cobalamin deficiency due to underlying diseases involving intestine or pancreas. Please check for Folic Acid deficiency as well and this may be related to nutritional deficiency. If you are a vegetarian, please take vitamin B12 daily. ...Read more

10

10
What is the best treatment for pernicious anemia?

What is the best treatment for pernicious anemia?

Vitamin B12: True pernicious anemia is due to a lack of absorption of vitamin b 12 from your gastrointestinal tract. The treatment would be vitamin B12 injections given by your doctor. Sometimes large doses of oral vitamin b12, 1 to 2 mg daily can also help replenish your levels of vitamin b12.Your doctor can help decide which approach is best for you. ...Read more

11

11
What causes pernicious anemia and what are some treatments for it?

What causes pernicious anemia and what are some treatments for it?

Low vitamin B12: Pernicious anemia is a condition in which the body is unable to absorb vitamin B12 through the stomach due to loss of a protein called intrinsic factor in the stomach. Treatment invovles replacing b! 2 through injections or nasal sprays- taking oral pills is ineffective. ...Read more

12

12
Is there a cure for pernicious anemia?

Is there a cure for pernicious anemia?

Treatable: This condition can be well treated with life-long use of B12 injections or nasal sprays and results in normalisation of the blood counts. ...Read more

14

14
I was recently diagnosed with pernicious anemia. My B12 was a 260. I take B12 tablets by mouth. Will I need injections in the future? My MCV is 96.8

I was recently diagnosed with pernicious anemia. My B12 was a 260. I take B12 tablets by mouth. Will I need injections in the future? My MCV is 96.8

Truly PA?: Normal mcv. Not all low b12= deficiency. Check methyl malonic acid, homocysteine levels-abnormal inb12 def. If so, check anti parietal cell antibodies-abmormal in pa. Megadose oral (2 mg) B12 can work once the tank is full. ...Read more

15

15
My mom gets pernicious anemia, so am I likely to get it later?

Pernicious Anemia: Pernicious anemia is not inheritated to my knowledge. It is usually caused by lack of the vitamins b 12 in diet (by vegetarians) or lack of intrinsic factors in autoimmune atrophic gastritis or in patients who had part of the stomach cut off for bariatric surgery (to reduce weight) or as surgical treatment for peptic or gastric ulcers (gastrostomy). ...Read more

16

16
Pernicious anemia and planning pregnancy. I currently get B12 injections bimonthly. Recommendations? B12 more often? What is recommended max dosis?

Pernicious anemia and planning pregnancy. I currently get B12 injections bimonthly. Recommendations? B12 more often? What is recommended max dosis?

Keep levels normal: A pernicious anemia patient can work with her primary care and ob-gyn doctor to find out how often she needs injections to keep her B12 level normal. Haven't seen any reports of B12 injections causing pregnancy problems, if the B12 is being used to prevent B12 deficiency. A common dose is 1mg each shot, with the patient getting a shot every few weeks or every month, depending on need. ...Read more

17

17
What is pernicious anemia?

Pernicious anemia: It's a condition which results in low vitamin B12 leading to anemia. The person affected with this condition needs the B12 supplement by injection route as oral absorption is impaired. ...Read more

18

18
What is pernicious anemia?

B12 deficiency: It is an autoimmune disease in which your body develops antibodies against intrinsic factor and gastric parietal cells which are needed to absorb b12, a vital nutrient. These patients will need to get im injections of b 12 lifeterm since they cannot absorb B12 naturally from their diet. ...Read more

19

19
Can pernicious anemia be cured?

Not usually.: Classical pernicious anemia is caused by auto-antibodies against intrinsic factor-producing parietal cells of the stomach. Treatment is lifelong vitamin B12 administration, which is safer than using immunosuppressive medications that could lead to severe infections. Other kinds of B12 deficiency can possibly cured depending on the cause. ...Read more

20

20
How can I treat pernicious anemia?

Cobalamin therapy: Try a trial of vitamin B12 (cobalamin) first and have a physician to repeat lab to ensure adequate dose. Also it may need additional therapies for cobalamin deficiency due to underlying diseases involving intestine or pancreas. Please check for Folic Acid deficiency as well and this may be related to nutritional deficiency. If you are a vegetarian, please take vitamin B12 daily. ...Read more

21

21
How is 'pernicious anemia' treated?

How is 'pernicious anemia' treated?

With B12!: Taken by injection, or with 2500 mcg oral B12. Can be associated with iron deficiency of gastric acid production is reduced! ...Read more

22

22
How do you treat pernicious anemia?

Vitamin B-12: Pernicious anemia is a complicated disease, but the end result is that patients become deficient in vitamin b-12. Therefore, the treatment primarily involves b-12 supplementation. ...Read more

23

23
Is pernicious anemia life-shortening?

Should not be!: It did shorten lives. But with B12, there should be no shortening of life!!!!!!!!!!!!!!!!!!! ...Read more

24

24
Could pernicious anemia shorten life?

Probably no: If you have pernicious anemia you do not absorb B12 effectively. That is easily fixed with either B12 injections or large B12 oral doses daily. Unfortunately, patients with B12 deficiency often have other associated autoimmune issues that develop. In general though, pa alone will not shorten life as long as you treat it correctly. ...Read more

25

25
What are the causes of pernicious anemia?

What are the causes of pernicious anemia?

Autoimmune disease: Pernicious anemia is an autoimmune disease producing autoantibodies against intrinsic factor found in the lining of the stomach. This leads to lack of absorption of vitamin B12 which is important in making blood cells and for nourishment of the nervous system. Treatment would be by replacement of B12 via injections or absorption into the body by other means (nasal spray). ...Read more

27

27
What are the symptoms for pernicious anemia?

Fatigue: Caused by an anemia with large red blood cells! Reversible quickly with B12! ...Read more

29

29
What are the causes of symptoms in pernicious anemia?

Lack of vitamin B12: Pernicious anemia is due to a lack of vitamin b12. B12 is necessary for the normal function of the nervous system and the formation of red blood cells. ...Read more

30

30
What symptoms of pernicious anemia are the most common?

What symptoms of pernicious anemia are the most common?

Fatigue: In pernicious anemia, there is no vitamin B12 absorption which causes low red blood cell production and leads to severe anemia. This causes fatigue most comonly. ...Read more

Dr. Steven Ginsberg
1,283 Doctors shared insights

Anemia (Definition)

Any condition where there is a decrease in the red blood ...Read more