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Doctor insights on: Periventricular White Matter Disease

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White Matter (Definition)

White matter is one of the two components of the central nervous system and consists of glial cells and myelinated axons that transmit signals from one region of the cerebrum to another and between the cerebrum and lower brain centers. White matter tissue of the freshly cut brain appears pinkish white to the naked eye because myelin is composed largely of lipid ...Read more


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What is chronic periventricular white matter microvascular ischemic disease?

What is chronic periventricular white matter microvascular ischemic disease?

Patchy insulation: Chronic means this process has been going on for years in the brain. White matter is the part of the brain where the "communication cables" are, and they are "white" because of myelin insulation. The ventricles are fluid-filled "shock absorber" spaces inside the brain. Ischemic means they have been deprived oxygen, microvascular means in tiny blood vessels. Mini-stroke strips off some insulation. ...Read more

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I recently had an MRI of the brain. The results where as follows mild atrophy and mild periventricular white matter ischemic small vessel disease. Wh?

I recently had an MRI of the brain. The results where as follows mild atrophy and mild periventricular white matter ischemic small vessel disease.  Wh?

Arteriosclerosis : You are taking hydrocodone, tramadol & Lyrica (pregabalin) for nagging pain plus Ambien for sleep and Buspirone for anxiety. Combination is heavy stuff. Had migraine but not any more? Microvascular disease is the blockage of tiny vessels-arteriosclerosis. These can happen in heart & kidney as well. Check your lipid profile and possible use of statin. For headache & reevaluation of all your meds see neurologist. ...Read more

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What is mild chronic ischemic changes in bilateral periventricular white matter?

What is mild chronic ischemic changes in bilateral periventricular white matter?

Described often: Presume on mri, white matter lesions as noted, which are usually nonspecific, but can be associated with hypertension, diabetes, or high blood fats causing "hardening of the arteries" (aka, microvascular angiopathy). This pattern might be consistent with ms in some cases, so needs correlation for relevance. Not a description of stroke, but an indication for prevention of future stroke. ...Read more

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Two MRIs both have shown "mild amount of signal hyperintensity in the periventricular white matter bilaterally." What could this mean?

 Two MRIs both have shown "mild amount of signal hyperintensity in the periventricular white matter bilaterally." What could this mean?

The description: is not very specific, and in the absence of clinical context, it is difficult to assess the significance. Most likely it is an incidental finding of little concern, but talk to your doctor about it. ...Read more

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Flair sequence demonstrates minimal increased signal in the periventricular white matter which is non specific. what does this mean and can it be MS?

Flair sequence demonstrates minimal increased signal in the periventricular white matter which is non specific. what does this mean and can it be MS?

Possible: If you have clinical abnormalities raising concern, this could be an early sign of MS. Best to see your neurologist and discuss this. Additional testing would involve possibly lumbar puncture, MRI of neck, and blood testing for other causes. Non-specific causes could include prior trauma, smoking, migraine, hypertension. ...Read more

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What is mild chronic ischemic changes in bilateral frontal periventricular white matter?

What is mild chronic ischemic changes in bilateral frontal periventricular white matter?

Nonspecific WM: Nonspecific periventricular white matter changes- These are normally small spots without clinical relevance. They are more common for people with high blood pressure, diabetes, head injuries or in people who smoke. They do not have a defined clinical meaning. ...Read more

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I am 35 female MRI states Punctate increased FLAIR signal foci in the periventricular white matter bilaterally.

I am 35  female MRI states  Punctate increased FLAIR signal foci in the periventricular white matter bilaterally.

ABNORMAL MRI: The abnormal MRI may have a variety of causes, Migraine Headaches, HTN, Diabetes. Depending on your symptoms , Full lab work including evaluation for Lyme disease / VIT d deficiency/ b12 folic acid /thyroid studies/ Sjogrens Syndrome and Sarcoid evaluations. Also potentially a clotting work up. Follow up with your Internist and Neurology Consult ...Read more

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A MRI was taken and the impression says abnormal T2 prolongation identified in the periventricular white matter region, what does this mean?

MRI: Your brain has ventricles which are fluid filled cavities on the inside of you brain. You have 4 two lateral venticles, and two midline. They are all conncected. You have brain structures that show up white on MRI in this area. T2 refers to the time it takes to spin the hydrogen atoms. An abnormal prolongation can be associated with metabolic problem ...Read more