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Doctor insights on: Periventricular And Subcortical White Matter Disease

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Age 66; right hearing loss; MRI; dx: mild chronic deep white matter ischemic changes in the periventricular and subcortical white matter. Please expla?

Age 66; right hearing loss; MRI; dx: mild chronic deep white matter ischemic changes in the periventricular and subcortical white matter. Please expla?

Becoming a senior: These changes in signal in the white matter are believed to be due to small vessels losing their flow. This is a finding in older or senior citizens. It remains to be seen if they amount to anything as we age ...Read more

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White Matter (Definition)

White matter is one of the two components of the central nervous system and consists of glial cells and myelinated axons that transmit signals from one region of the cerebrum to another and between the cerebrum and lower brain centers. White matter tissue of the freshly cut brain appears pinkish white to the naked eye because myelin is composed largely of lipid ...Read more


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Mri result very few scattered punctate foci of flair 2 signal abnormality seen in periventricular and subcortical white matter. History concussion, htn?

Mri result very few scattered punctate foci of flair 2 signal abnormality seen in periventricular and subcortical white matter. History concussion, htn?

More likely HTN: Mri scans that demonstrate the scattered periventricular signal changes are likely showing changes from hypertension. This is a typical location for this. Severe concussions may show some signal abnormalities along the white matter tracks (diffuse axonal injury) rather than in the periventricular zones. ...Read more

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Brain MRI findings. Tiny nonspecific periventricular and subcortical white matter. Possiblities mini strokes, vasculaties, ms. I shuffle my feet & drop?

Brain MRI findings. Tiny nonspecific periventricular and subcortical white matter. Possiblities mini strokes, vasculaties, ms. I shuffle my feet & drop?

Nonspecific finding: White matter changes that are nonspecific are sometimes over reported or under-reported on MRI studies. They may be misread and really suggest MS, they may be a finding with no clinical relevance. Usually it is the latter.

It sounds like the brain MRI did not help that much. So you shuffle your feet and drop? What do you mean by drop? Do you have numbness? Why was the brain MRI done? ...Read more

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Re: MRI brain - foci periventricular and subcortical resolved (?) but new foci in right frontal white matter what would this indicate?

Re: MRI brain - foci periventricular and subcortical resolved (?) but new foci in right frontal white matter what would this indicate?

DEMYELINATION: What you describe is a sequence of new and old lesions consistent with an active disease process. Although a number of disorders could present this way, by and far, the most likely cause is multiple sclerosis. The diagnosis needs confirmation, and treatment should be initiated asap. Do not delay, find a good neurologist (lots of them in boston). ...Read more

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Minimal right periventricular white matter signal abnormality seen on flair and t2. Tiny punctate focus in the subcortical white matter frontal lobe. Symptoms of joint pain in hands and right leg weak?

Minimal right periventricular white matter signal abnormality seen on flair and t2. Tiny punctate focus in the subcortical white matter frontal lobe. Symptoms of joint pain in hands and right leg weak?

Possible Autoimmune: The symptoms and MRI suggest an autoimmune inflammatory condition. Ms is a contender but joint pains are not a usual feature of ms but suggest a rheumatological condition. While rheumatologic conditions may mimic ms, sometimes these disorders may coexist. ...Read more

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What is chronic periventricular white matter microvascular ischemic disease?

What is chronic periventricular white matter microvascular ischemic disease?

Patchy insulation: Chronic means this process has been going on for years in the brain. White matter is the part of the brain where the "communication cables" are, and they are "white" because of myelin insulation. The ventricles are fluid-filled "shock absorber" spaces inside the brain. Ischemic means they have been deprived oxygen, microvascular means in tiny blood vessels. Mini-stroke strips off some insulation. ...Read more

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MRI showed moderate supratenatorial white matter disease suspicious of demyelinating process. Multiple nodular foci periventricular Could you explain?

MRI showed moderate supratenatorial white matter disease suspicious of demyelinating process. Multiple nodular foci periventricular Could you explain?

Concern for MS, But: Phyllis, talk to the doctor who ordered the MRI, since he/she can interpret the MRI in the context of the symptoms that brought you to the clinic. In some cases, periventricular white matter lesions are the result of migraines, old head trauma, neuron migration issues, or MS. It is hard to know from just a description of the MRI which is the cause. Good Luck and Stay Healthy! ...Read more

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I recently had an MRI of the brain. The results where as follows mild atrophy and mild periventricular white matter ischemic small vessel disease. Wh?

I recently had an MRI of the brain. The results where as follows mild atrophy and mild periventricular white matter ischemic small vessel disease. Wh?

Arteriosclerosis: You are taking hydrocodone, tramadol & Lyrica (pregabalin) for nagging pain plus Ambien for sleep and Buspirone for anxiety. Combination is heavy stuff. Had migraine but not any more? Microvascular disease is the blockage of tiny vessels-arteriosclerosis. These can happen in heart & kidney as well. Check your lipid profile and possible use of statin. For headache & reevaluation of all your meds see neurologist. ...Read more

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81 year old mother, CT periventricular deep white matter changes and moderate small vessel iscjaemic disease. Serious?

81 year old mother, CT periventricular deep white matter changes and moderate small vessel iscjaemic disease. Serious?

CT changes: These changes are very common for any person at this age. She needs to eat healthy, exercise regularly and have her blood pressure, cholesterol and blood sugar under good control. ...Read more

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What is mild chronic ischemic changes in bilateral periventricular white matter?

What is mild chronic ischemic changes in bilateral periventricular white matter?

Described often: Presume on mri, white matter lesions as noted, which are usually nonspecific, but can be associated with hypertension, diabetes, or high blood fats causing "hardening of the arteries" (aka, microvascular angiopathy). This pattern might be consistent with ms in some cases, so needs correlation for relevance. Not a description of stroke, but an indication for prevention of future stroke. ...Read more

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Mild atrophy with fairly prominentperiventricular and subcortical nonspecific white matter changes. Chronic. What does this mean?

Mild atrophy with fairly prominentperiventricular and subcortical nonspecific white matter changes. Chronic. What does this mean?

See below: These findings are not uncommon in older persons. They are nonspecific but are more frequently related to chronic small vessel ischemic disease from diabetes or hypertension. The more severe the findings, the more likely they may be related to future development of vascular dementia. If the findings are in a young person, they could be from mutlple sclerosis or other causes & need further eval. ...Read more

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What does scattered althought predominantely bilateral frontal, subcortical white matter punctuate foci of signal abnormality mean?

What does scattered althought predominantely bilateral frontal, subcortical white matter punctuate foci of signal abnormality mean?

Maybe nonspecific: If you have migraine, such white matter lesions are usually posterior, and if you had head trauma, the location may be more anterior, but both head and neck trauma could cause some increased foci. The demyelinating lesions of ms would be periventicular at right angles, but in the elderly such lesions might be c/w microvacular angiopathy, or even binwanger's. ...Read more

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Two MRIs both have shown "mild amount of signal hyperintensity in the periventricular white matter bilaterally." What could this mean?

Two MRIs both have shown "mild amount of signal hyperintensity in the periventricular white matter bilaterally." What could this mean?

The description: Is not very specific, and in the absence of clinical context, it is difficult to assess the significance. Most likely it is an incidental finding of little concern, but talk to your doctor about it. ...Read more