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Doctor insights on: Periactin Antihistamine

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For educational purposes, i look up any meds i take. Which cytochrome p450 enzymes metabolize the first-gen antihistamine periactin? Or are effected?

For educational purposes, i look up any meds i take. Which cytochrome p450 enzymes metabolize the first-gen antihistamine periactin? Or are effected?

Cyproheptadine: Aromatic ring hydroxylation ( followed by glucuronide conjugation), and n-demethylation, end heterocyclic ring oxidation were shown to occur in man. The principal metabolite, however, was identified tentatively as a quaternary ammonium. Glucuronide-like conjugate of cyproheptadine. The exact mechanisms for the glucuronidation are not entirely clear. ...Read more

Dr. Lonnie Smith
34 doctors shared insights

Cyproheptadine Hydrochloride (Definition)

Cyproheptadine hydrochloride is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more


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Does periactin make you gain weight? Please, need some answers?

Does periactin make you gain weight? Please, need some answers?

Yes, it can: Periactin (cyproheptadine), is mainly used as an antihistamine, particularly for cold-induced urticaria (welts caused by cold objects). It also has effects on the brain, including sedation and increase in appetite, leading to weight gain. ...Read more

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Are there any alternates similar to periactin (cyproheptadine)?

Could be several but: It depends why you are taking it...This is an antihistamine which helps itching. But, it can make you sleepy, or even hungry(sometimes given to increase appetite). There are several over the counter anti-histamines(which you to be available only by prescription) which are very helpful --allegra, zyrtec, claritin. Read the labels and see if they help you. If not check with the dr. Who prescribed it. ...Read more

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Can periactin relief toothaches?

Can periactin relief  toothaches?

No: Periactin is an antihistamine. It is used sometimes off label to treat cluster headaches or migraine headaches but not for tooth aches. It is mainly used to treat seasonal allergies. ...Read more

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Can periactin provide benefit for the relief of toothaches?

Perhaps: If the toothache is more a result of some kind of sinus problem the the anti-histamine periactin might provide some relief. Otherwise not. ...Read more

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After ceasing to take periactin, my behaviour has changed, could be withdrawal?

After ceasing to take periactin, my behaviour has changed, could be withdrawal?

Not withdrawal: Periactin (cyproheptidine) makes you sleepy. Sometimes it makes you hungry but it's not habit-forming or addictive. If you feel more alert, less drowsy, have more energy, and decreased appetite that's just the effects of this classical antihistamine wearing off. ...Read more

Dr. Paul Carter
593 doctors shared insights

Antihistamine (Definition)

Sedating and non-sedating antihistamines prevent and treat allergic reactions, and are ...Read more


Dr. Warren Foster
37 doctors shared insights

Periactin (Definition)

Periactin is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more