Doctor insights on:
For educational purposes, i look up any meds i take. Which cytochrome p450 enzymes metabolize the first-gen antihistamine periactin (cyproheptadine hydrochloride)? Or are effected?
Cyproheptadine: Aromatic ring hydroxylation ( followed by glucuronide conjugation), and n-demethylation, end heterocyclic ring oxidation were shown to occur in man. The principal metabolite, however, was identified tentatively as a quaternary ammonium. Glucuronide-like conjugate of cyproheptadine. The exact mechanisms for the glucuronidation are not entirely clear. ...Read more
Does Benadryl (diphenhydramine) share any of the anti-serotoninergic effects that periactin has? Or is a sert inhibitor the opposite? Having seritonin migraine..
Neither..4 most part: Benadryl (diphenhydramine) is an antihistamine. As a potent antagonist to acetylcholine in muscarinic receptors, Diphenhydramine is used to treat parkinson's disease-like extrapyramidal symptoms caused by typical antipsychotics. It haslso been shown to weakly inhibit the reuptake of serotonin. ...Read more
Is it bad to take an antihistamine during a cold, i.e. does suppressing mucus make the cold last longer?
No value: Antihistamines have no value in the treatment of viral illnesses. ...Read more