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Doctor insights on: Periactin Antihistamine

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For educational purposes, i look up any meds i take. Which cytochrome p450 enzymes metabolize the first-gen antihistamine periactin (cyproheptadine hydrochloride)? Or are effected?

For educational purposes, i look up any meds i take. Which cytochrome p450 enzymes metabolize the first-gen antihistamine periactin (cyproheptadine hydrochloride)? Or are effected?

Cyproheptadine: Aromatic ring hydroxylation ( followed by glucuronide conjugation), and n-demethylation, end heterocyclic ring oxidation were shown to occur in man. The principal metabolite, however, was identified tentatively as a quaternary ammonium. Glucuronide-like conjugate of cyproheptadine. The exact mechanisms for the glucuronidation are not entirely clear. ...Read more

Dr. Neigatha Graney
34 doctors shared insights

Cyproheptadine Hydrochloride (Definition)

Cyproheptadine hydrochloride is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more


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Does Benadryl (diphenhydramine) share any of the anti-serotoninergic effects that periactin has? Or is a sert inhibitor the opposite? Having seritonin migraine..

Does Benadryl (diphenhydramine) share any of the anti-serotoninergic effects that periactin has? Or is a sert inhibitor the opposite? Having seritonin migraine..

Neither..4 most part: Benadryl (diphenhydramine) is an antihistamine. As a potent antagonist to acetylcholine in muscarinic receptors, Diphenhydramine is used to treat parkinson's disease-like extrapyramidal symptoms caused by typical antipsychotics. It haslso been shown to weakly inhibit the reuptake of serotonin. ...Read more

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What are the common uses of antihistamine?

Antihistamine 4 itch: Antihistamines (ah) block histamine receptors and stop histamine from causing itching and swelling. They are mainly used to treat allergies and hives. Some are sedating; those are used as sleep aids. Many otc sleep meds contain Diphenhydramine (benadryl). ...Read more

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Is Flixonase an antihistamine?

Is Flixonase an antihistamine?

Steroid Nasal Spray: Flixonase or Flonase (fluticasone proprionate) is a steroid nasal spray commonly used to treat allergic rhinitis by decreasing the allergic inflammation in the nasal mucosa. It is not an antihistamine. ...Read more

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Is there an antihistamine cream?

Is there an antihistamine cream?

Yes, but avoid: Benadryl (diphenhydramine) cream is available. While some people find temporary relief for insect bites with this, in general it is not very effective compared to other antihistamines taken as pills or tabs. For generalized rash, it really doesn't make sense. ...Read more

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What antihistamine has the strongest antiemetic properties?

Dramamine (dimenhydrinate): Dramamine (dimenhydrinate) and Meclizine are some that can be used. Different for different patients. ...Read more

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If someone takes 52 antihistamines, is this something to be concerned about?

If someone takes 52 antihistamines, is this something to be concerned about?

Yes: It tells me that this is a risky behavior and likely a suicidal attempt. Call the psychiatrist or the suicide hotline. ...Read more

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Is Flonase an antihistamine?

Is Flonase an antihistamine?

No: Flonase is a nasal steroid spray. It is often used in conjunction with an antihistamine. The most commonly used antihistamines today are the non-sedating antihistamines: claritin, Allegra and zyrtec. Each of these had a generic drug available, too. ...Read more

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Dr. Paul Carter
601 doctors shared insights

Antihistamine (Definition)

Sedating and non-sedating antihistamines prevent and treat allergic reactions, and are ...Read more


Dr. Ira Katz
37 doctors shared insights

Periactin (Definition)

Periactin is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more