Doctor insights on:
Pepsin Side Effects
I'm weening myself off Prevacid (lansoprazole) with the help of a Betaine/Pepsin HCL pill every morning. It helps but I now have heart palpitations. Side effect?
Betaine HCL/pepsin: There are no reported cases on palpitations but theoretically the pepsin/HCL combo could have negative vagal feedback ( vagus stimulation produces pepsin on our stomach). The vagus nerve via parasympathetic stmulation slows the heart and if it is inhibited there could be increase heart rate. You could try stopping the meds and seeing if palpitations stop. Check B6, folate (folic acid) ,B12 .F/U with doc. ...Read more
Amino acid links: Pepsin is an enzyme whose zymogen (pepsinogen) is released by the chief cells in the stomach and that degrades food proteins into peptides. Pepsin is most efficient in cleaving peptide bonds between hydrophobic and preferably aromatic Amino Acids such as phenylalanine, tryptophan, and tyrosine. ...Read more
So theoretically - if you did not eat any protein - then surely the pepsin would not be activated?
None: Pepsin, the powerful enzyme in gastric juice that digests proteins such as those in meat, eggs, seeds, or dairy products in the stomach. Once in the small intestine, the ph is higher rendering pepsin inactive in further digestion of proteins. Absorption of proteins occurs primarily in the small intestine. ...Read more
PPIs;H2blockers: Proton pump inhibiters like omeprazole, nexium, Prevacid or dexelent by itself or in combination with h2 blockers like ranatadine; Reglan (metoclopramide) will relieve the symptoms of non acid laryngopharyngeal reflux.Robinul forte can also be used as it cuts down the pepsin secretion to some extent. Along with that life style modifications, elevating the head end of bed avoidfoods like dairy, wheat;eggs, wt loss. ...Read more
Stop it.: There is no good research that I can find that says this even works! Since there is no unbiased information about the product, then info on side effects will also likely be biased. Stop it. If your diarrhea does not improved, see your doc. Eat okra, the vegetable, instead of a pill, instead. It's high in fiber and has other good things in it. ...Read more