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Doctor insights on: People With Lupus Told They Have Double Stranded Dna

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Does false positive ELISA mean the person has autoimmune disease? Do people ever find out why they get these results?

Does false positive ELISA mean the person has autoimmune disease? Do people ever find out why they get these results?

Need more info: Elisa is an acronym for enzyme-linked immuno-sorbent assay. It is an immunological test that can be used for detection of various antibodies, antigens and certain chemicals. You don't mention what your elisa was positive to. Without that information i can't answer your question. ...Read more

Dna (Definition)

Dna are the coding molecules found in all living things on earth which contain the instructions on how to build living things. Its is comprised the nucleotide molecules which are ...Read more


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Can someone with normal lab results still have lupus or RA or othe autoimmune diseases?

Can someone with normal lab results still have lupus or RA or othe autoimmune diseases?

Possibly: About 98-99 percent of people with Lupus have a positive ANA test so it be unlikely to have lupus with a negative ANA blood test. On the other hand, in rheumatoid arthritis, especially in the early phases, a much larger minority of people may have a normal Rheumatoid factor test (but many of those people may have a positive CCP ab test that is seen in RA). Bottom line: possible but unlikely. ...Read more

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Do people with lupus have the lupus anticoagulant?

Not necessarily: Although many people with lupus have lupus anticoagulant not all do. And most people with lupus anticoagulant do not have lupus. Patients with lupus are more likely to develop the lupus anticoagulant than the general population so it is one "marker" for the disease. ...Read more

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Would bloods for autoimmune screen ANA double stranded DNA ENA anca still show positive if there had been an autoimmune response even 6 years ago?

Would bloods for autoimmune screen ANA double stranded DNA ENA anca still show positive if there had been an autoimmune response even 6 years ago?

See below: You also have to take in account that these panels frequently have false positives and assays vary from lab to lab. It is has been estimated that up 30% of all anas drawn are false positives. Only your doctor or your rheumatologist can interpret these results in context with your history and symptoms. ...Read more

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What are some causes of an over active immune system with a monoclonal T cell Beta gene receptor finding ? Have tested negative for Ana / RA / viruses

What are some causes of an over active immune system with a monoclonal T cell Beta gene receptor finding ? Have tested negative for Ana / RA / viruses

No simple answer.: t-cell receptor studies prove clonality, meaning an expansion of a single line of T-cells, a kind of immune system cell. The test is mainly used to confirm the presence of T-cell cancers, but is not sufficient for cancer diagnosis because it's too sensitive and not specific. Anything that stimulates the immune system, infections, autoimmune diseases, inflammatory states, will produce a positive. ...Read more

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Labs done on accident, high ANA and AntiCentromere B Antibody. No symptoms Diagnosed with CREST does this mean I have it now? Or will have it later?

Labs done on accident, high ANA and AntiCentromere B Antibody. No symptoms Diagnosed with CREST does this mean I have it now? Or will have it later?

No symptoms: A diagnosis is made based on symptoms and objective findings and not on lab findings alone. You don't have CREST if you do have any symptoms or findings compatible with the disease. Another question: If a lab did a very specialized study on you by accident, could it have also mixed up your blood sample with another person's? I would recommend repeating the test in a few months . ...Read more

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Can I still have lupus if my ANA and other antibodies are negative except the cardiolipin IgM and lupus coagulant! I have all the symptoms for lupus.

Can I still have lupus if my ANA and other antibodies are negative except the cardiolipin IgM and lupus coagulant! I have all the symptoms for lupus.

Yes,amongst other Dx: Anti-cardiolipin antibodies are antibodies often directed against cardiolipin & found in several diseases, including syphilis,antiphospholipid syndrome,livedoid vasculitis, vertebrobasilar insufficiency,Behçet's syndrome,idiopathic spontaneous abortion,] and systemic lupus erythematosus(SLE).They are a form of anti-mitochondrial antibody. In SLE,anti-DNA Abs &anti-cardiolipin Abs act independently ...Read more

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Positive ana, dbl-stranded result indeterminate, smith and sl-70, and ss-a/ss-b all borderline with many sle symptoms. What does these mean?

See details: The ANA means nothing by itself as it must be evaluated in terms of the clinical symptoms. If the clinical picture is consistent with lupus, then you have lupus. If it is not, then the ANA is potentially not that important. Have you seen a rheumatologist? If you have, you need to discuss the findings with that doctor. If you haven't, you need to see one. ...Read more

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If my ANA tested positive (1:160), do I absolutely have an autoimmune disorder of some type?

See here: Please see the link below especially under a "word of caution" to help answer your question. http://www.uptodate.com/contents/antinuclear-antibodies-ana-beyond-the-basics ...Read more

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Do people that are hlab27 positive also have raised ana?

Do people that are hlab27 positive also have raised ana?

Not necessarily: Hla b27 is a genetic test that increases the risk of ankylosing spondylitis and related conditions. ANA is a general screening test for autoimmune disease, but is most often used to screen for lupus or other connective tissue disease, not ankylosing spondylitis. Should discuss with your doctor why he/she tested for both of them. ...Read more

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At 41 I have minor joint pain, fatigue and ai family history. My rheum has only begun with my diagnosis. I had mono at 19. Could EBV affect antibody testing results or even replicate an ai disorder?

At 41 I have minor joint pain, fatigue and ai family history. My rheum has only begun with my diagnosis. I had mono at 19. Could EBV affect antibody testing results or even replicate an ai disorder?

Wait for answer: Everyone has ebv in his body and thus it is not the cause for a autoimmune disease. Ebv antibody titer increases with many disorders since the virus resides in the lymphocytes which are the immune cells. Be patient and allow your rheumatologist the time to get you the answer. ...Read more

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I had a positive ANA of 1:40 Nucleolar pattern and an anti DS DNA come back high at 6 along with multiple Lupus symptoms. Does this mean I have Lupu?

May be: A number of criteria need to be met to diagnose lupus. You may consult this site that lists the various criteria and the number needed for the diagnosis. http://www.lupus.org/answers/entry/lupus-diagnostic-criteria Wish you good health! ...Read more

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Hi there, I have sjögrens syndrome and mild lupus but my double strand DNA was neg, my ANA was 1:640 with speckled pattern. How can it be mild lupus?

Hi there, I have sjögrens syndrome and mild lupus but my double strand DNA was neg, my ANA was 1:640 with speckled pattern. How can it be mild lupus?

Questionable: No one knows what lupus really is, so it's defined in terms of a checklist. A certain total number of findings allows the diagnosis to be made. The real question is, "do we treat, and if so, how?" good luck -- sjogren's alone is quite a challenge, and often runs with lupus or lupus-like illness and gives its own positive ana. ...Read more

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What definitive lab test can r/o or confirm lupus while prego? + hashimotos , also + ana, +double stranded DNA . How do I determine a true yes or no?

See details: First of all, see a rheumatologist if you have not done so already. While an ANA can often be positive in hashimoto's it is much more unusual for the dna to be positive. Since you do not list your symptoms, it is impossible to offer a more specific opinion. ...Read more

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Are shingles contagious to other people who have had chicken box previously in life but have a low immune system now?

Are shingles contagious to other people who have had chicken box previously in life but have  a low immune system now?

How low?: You should have natural immunity if you had chicken pox, but depending on what is making your immne system "low", you could have some susceptibility. If you are going through current chemo, or high dose immune suppressive drugs, had total body radiation for something like a bone marrow transplant, could get the infection. If mild suppression of immune system, trasmission unlikely. ...Read more